DERMAL TOXICITY OF LINEAR ALKYLBENZENE SULPHONATE AND NICKEL IN GUINEA PIGS

2001 ◽  
Vol 20 (1) ◽  
pp. 23-27 ◽  
Author(s):  
A. K. Mathur ◽  
Ravi Shanker
Keyword(s):  
Guinea Pigs ◽  
Dermal Toxicity ◽  
Linear Alkylbenzene ◽  
Linear Alkylbenzene Sulphonate

Dermal Toxicity of Linear Alkylbenzene Sulfonate and Quinalphos in Guinea Pigs

2000 ◽  
Vol 19 (1) ◽  
pp. 43-53
Author(s):  
A. K. MATHUR ◽  
B. N. GUPTA ◽  
A. SINGH ◽  
M. K. SRIVASTAVA ◽  
R. B. RAIZADA
Keyword(s):  
Guinea Pigs ◽  
Linear Alkylbenzene Sulfonate ◽  
Dermal Toxicity ◽  
Linear Alkylbenzene ◽  
Alkylbenzene Sulfonate

Effect of linear alkylbenzene sulphonate (LAS) on non-specific defence mechanisms in rainbow trout (Oncorhynchus mykiss)

2005 ◽  
Vol 71 (2) ◽  
pp. 175-181 ◽  
Author(s):  
Tülay Bakırel ◽  
Oya Keleş ◽  
Süheyla Karataş ◽  
Mukaddes Özcan ◽  
Gülhan Türkmen ◽  
...  
Keyword(s):  
Rainbow Trout ◽  
Oncorhynchus Mykiss ◽  
Defence Mechanisms ◽  
Linear Alkylbenzene ◽  
Rainbow Trout Oncorhynchus Mykiss ◽  
Linear Alkylbenzene Sulphonate

Iso‐Branching of linear alkylbenzene sulphonate (LAS). Biodegradation study of two model compounds

1996 ◽  
Vol 54 (1-4) ◽  
pp. 167-186 ◽  
Author(s):  
L. Cavalli ◽  
G. Cassani ◽  
M. Lazzarin ◽  
C. Maraschin ◽  
G. Nucci ◽  
...  
Keyword(s):  
Model Compounds ◽  
Linear Alkylbenzene ◽  
Biodegradation Study ◽  
Linear Alkylbenzene Sulphonate

Acute Dermal Irritation, Sensitization, and Acute Toxicity Studies of a Transdermal Patch for Prophylaxis Against (±) Anatoxin-A Poisoning

2013 ◽  
Vol 32 (4) ◽  
pp. 308-313 ◽  
Author(s):  
Subham Banerjee ◽  
Pronobesh Chattopadhyay ◽  
Animesh Ghosh ◽  
Manash Pratim Pathak ◽  
Shweta Singh ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Day Treatment ◽  
Skin Irritation ◽  
Positive Control ◽  
Transdermal Patch ◽  
Dermal Toxicity ◽  
Placebo Patch ◽  
Dermal Irritation ◽  
Transdermal Patches ◽  
Skin Irritation Test

The skin irritating, sensitizing, and acute dermal toxicity potential of a novel combinational prophylactic transdermal patch, mainly composed of eserine and pralidoxime chloride as active pharmaceutical ingredients, against (±) anatoxin-a poisoning were investigated in rabbits, guinea pigs, and rats in compliance with the Organisation for Economic Cooperation and Development guidelines. In primary skin irritation test, rabbits were dermally attached with the therapeutically active transdermal patch or with a placebo patch for 72 hours. The transdermal patches did not induce any adverse reactions such as erythema and edema on intact skin sites. The active patch was classified as a practically nonirritating material based on the score in the primary irritation index. In the Buehler test, guinea pigs were sensitized by the active or placebo transdermal patches attached for 24 hours. The patches did not induce any sensitization reactions in contrast to a severe sensitization reaction that occurred in the positive control. Therefore, the active patch and placebo patch were both graded as weak in sensitization score and rate. Acute dermal toxicity test in rats did not produce any overt signs of toxicity following a 14-day treatment period. Taken together, these findings suggest that the transdermal patch does not cause skin irritation, skin sensitization, or dermal toxic effects following dermal application.

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