Circadian Time‐Dependent Differences in Murine Tolerance to the Antihistaminic Agent Loratadine

2005 ◽  
Vol 22 (3) ◽  
pp. 499-514 ◽  
Author(s):  
Dorra Dridi ◽  
Naceur A. Boughattas ◽  
Karim Aouam ◽  
Alain Reinberg ◽  
Mossadok Ben Attia
Keyword(s):  
Time Dependent ◽  
Circadian Time ◽  
Antihistaminic Agent

scholarly journals Circadian Time-Dependent Tumor Suppressor Function of Period Genes

2009 ◽  
Vol 8 (4) ◽  
pp. 309-316 ◽  
Author(s):  
Xiaoming Yang ◽  
Patricia A. Wood ◽  
Christine Ansell ◽  
William J. M. Hrushesky
Keyword(s):  
Tumor Suppressor ◽  
Time Dependent ◽  
Tumor Suppressor Function ◽  
Suppressor Function ◽  
Circadian Time

scholarly journals Rhythmic Interaction between Period1 mRNA and hnRNP Q Leads to Circadian Time-Dependent Translation

2011 ◽  
Vol 32 (3) ◽  
pp. 717-728 ◽  
Author(s):  
K.-H. Lee ◽  
K.-C. Woo ◽  
D.-Y. Kim ◽  
T.-D. Kim ◽  
J. Shin ◽  
...  
Keyword(s):  
Time Dependent ◽  
Circadian Time

Murine circadian time-dependent tolerance to the immunosuppressive agent mycophenolate mofetil (MMF)

2013 ◽  
Vol 44 (3) ◽  
pp. 493-501
Author(s):  
Ichrak Dridi ◽  
Wafa Ben-Cherif ◽  
Karim Aouam ◽  
Mossadok Ben-Attia ◽  
Alain Reinberg ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Immunosuppressive Agent ◽  
Time Dependent ◽  
Circadian Time

Clocks, cancer, and chronochemotherapy

Science ◽  
2020 ◽  
Vol 371 (6524) ◽  
pp. eabb0738
Author(s):  
Aziz Sancar ◽  
Russell N. Van Gelder
Keyword(s):  
Gene Expression ◽  
Animal Studies ◽  
Time Dependent ◽  
Specific Interactions ◽  
Improved Outcomes ◽  
Circadian Time ◽  
Daily Rhythmicity ◽  
Clinical Potential ◽  
The Relationship ◽  
Oriented Research

The circadian clock coordinates daily rhythmicity of biochemical, physiologic, and behavioral functions in humans. Gene expression, cell division, and DNA repair are modulated by the clock, which gives rise to the hypothesis that clock dysfunction may predispose individuals to cancer. Although the results of many epidemiologic and animal studies are consistent with there being a role for the clock in the genesis and progression of tumors, available data are insufficient to conclude that clock disruption is generally carcinogenic. Similarly, studies have suggested a circadian time-dependent efficacy of chemotherapy, but clinical trials of chronochemotherapy have not demonstrated improved outcomes compared with conventional regimens. Future hypothesis-driven and discovery-oriented research should focus on specific interactions between clock components and carcinogenic mechanisms to realize the full clinical potential of the relationship between clocks and cancer.

Circadian Time-Dependent Kinetics of Theophylline and Its Modulation by Phenobarbital Pretreatment in Rats

1993 ◽  
Vol 10 (2) ◽  
pp. 81-86
Author(s):  
D. Zeruesenay ◽  
W. Siegmund ◽  
G. Franke ◽  
M. Zschiesche
Keyword(s):  
Time Dependent ◽  
Circadian Time ◽  
Kinetics Of
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