Gene Expression Profiling of Node-Negative Breast Tumors Reveals Metastatic Recurrence Risk

2004 ◽  
Vol 32 (1) ◽  
pp. 163-163
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Breast Tumors ◽  
Recurrence Risk ◽  
Node Negative ◽  
Metastatic Recurrence

scholarly journals Gene expression profiling of triple-negative breast tumors with different expression of secreted protein acidic and cysteine rich (SPARC)

2018 ◽  
Vol 7 (2) ◽  
pp. BMT09
Author(s):  
Paulo R de Alcantara Filho ◽  
Flavia R Mangone ◽  
Ana C Pavanelli ◽  
Simone A de Bessa Garcia ◽  
Suely Nonogaki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Triple Negative ◽  
Breast Tumors ◽  
Secreted Protein

Gene Expression Profiling in Lymph Node-Positive and Lymph Node-Negative Pancreatic Cancer

Pancreas ◽  
2007 ◽  
Vol 34 (3) ◽  
pp. 325-334 ◽  
Author(s):  
Han Na Kim ◽  
Dong Wook Choi ◽  
Kyu Taek Lee ◽  
Jong Kyun Lee ◽  
Jin Seok Heo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pancreatic Cancer ◽  
Lymph Node ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Node Negative ◽  
Node Positive ◽  
Lymph Node Positive

scholarly journals IMPARTER, Phase 1 of an intervention to improve patients’ understanding of gene expression profiling tests in breast cancer

2021 ◽  
Author(s):  
Lesley Jean Fallowfield ◽  
Daniel Farewell ◽  
Hywel Jones ◽  
Shirley Lesley May ◽  
Susan Lesley Catt ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Phase 1 ◽  
Recurrence Risk ◽  
Maximum Score ◽  
Information Leaflets ◽  
Film Viewing ◽  
Time Point

Abstract Purpose To compare participants’ knowledge about Gene Expression Profiling (GEP) tests and recurrence risks after reading an information leaflet with that following viewing of an information film. Methods Using a randomised cross-over design, at time-point one (T1) women aged 45–75 years without breast cancer, either read leaflets or watched information films about Oncotype DX or Prosigna tests. Participants answered nine questions assessing knowledge, (maximum score 18). Next day information in the opposite modality was provided and knowledge re-assessed. Additional questions probed which format was easiest to understand, participants’ preferences for film or leaflet and their reasons for these. Results 120 women participated (60 received OncotypeDX films and leaflets; 60 the Prosigna versions). T1 mean knowledge scores were higher following film viewing (13.37) compared with that after reading leaflets (9.25) (mean difference 4.1; p < 0.0001; 95% CI 3.2, 5.0). When participants read leaflets first and subsequently viewed films, all increased their scores (mean + 6.08, from T1 of 9.25, p < 0.0001; 95% CI 5.44, 6.72). When films were viewed first, followed by leaflets, (36/60, 60%) participants’ scores declined (mean-1.55 from T1 of 13.37, p < 0.001; 95% CI -2.32, -0.78). A majority of participants expressed preferences for the films (88/120, 73.3%) irrespective as to whether they described OncotypeDX or Prosigna. Reasons included the clarity, ease of understanding, visual material and reassuring voice-over. Conclusion Discussions between oncologists and patients about recurrence risk results can be challenging. Information leaflets may aid understanding but often employ complex language. Information films significantly improved knowledge and were preferred by participants.

Gene Expression Profiling in Lymph Node-Positive and Lymph Node-Negative Colorectal Cancer

2004 ◽  
Vol 47 (2) ◽  
pp. 141-152 ◽  
Author(s):  
Hyuk-Chan Kwon ◽  
Sung-Hyun Kim ◽  
Mee-Sook Roh ◽  
Jae-Seok Kim ◽  
Hyung-Sik Lee ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Lymph Node ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Node Negative ◽  
Node Positive ◽  
Lymph Node Positive

scholarly journals PCR analysis of the effect of photodynamic therapy on breast tumors

2021 ◽  
Vol 10 (12) ◽  
pp. e459101220468
Author(s):  
Isabelle Ferreira ◽  
Glenda Nicioli da Silva ◽  
Juliana Ferreira-Strixino ◽  
Clovis Grecco ◽  
Vanderlei Salvador Bagnato ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Breast Tumor ◽  
Breast Tumors ◽  
Female Rats ◽  
Control Group ◽  
Her 2

Photodynamic therapy (PDT) is a promising therapeutic modality for treating cancer, including breast tumors. The oxidative damage caused by PDT culminates in cell death, induction of immune response, and the resulting destruction of the tumor. This study aimed to evaluate the gene expression profiling of genes BCL-2, BAX, and HER-2 and their proteins after PDT, associating it with the necrosis caused by this therapy under different fluences. Twenty-eight female rats received a single dose of 7,12-dimethylbenz (a) anthracene (DMBA - 80mg/kg), by gavage, for breast tumor induction. After the tumors grew, the animals were divided into four groups: G1 - control group – untreated breast tumor – and G2, G3, and G4 groups treated with PDT using Photogem@ as photosensitizer and interstitial irradiation, with fluences of 50J/cm, 100J/cm, and 150J/cm, respectively. Samples of tumors were harvested for histological examination by RT-qPCR. The RT-qPCR showed that the gene expression profiling of BCL-2, BAX, and HER-2 was not altered after PDT. Hemorrhagic necrosis and qualitatively greater vascular and cellular damage were observed and correlated positively with the fluence. PDT does not seem to induce the modulation of genes related to apoptosis. The results indicate that the type of cell death stimulated by PDT in breast tumor is necrosis.

Postoperative prognosis of node-negative breast cancers predicted by gene-expression profiling on a cDNA microarray of 25,344 genes

Breast Cancer ◽  
2005 ◽  
Vol 12 (3) ◽  
pp. 166-177 ◽  
Author(s):  
Koji Tsumagari ◽  
Kazuo Chijiiwa ◽  
Hisaki Nagai ◽  
Masujiro Makita ◽  
Fujio Kasumi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Cdna Microarray ◽  
Expression Profiling ◽  
Breast Cancers ◽  
Node Negative ◽  
Postoperative Prognosis
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