scholarly journals Expression of Base Excision DNA Repair Genes is a Sensitive Biomarker for In Vivo Detection of Chemical-Induced Chronic Oxidative Stress

2004 ◽  
Vol 32 (1) ◽  
pp. 158-159
Keyword(s):  
Oxidative Stress ◽  
Dna Repair ◽  
Dna Repair Genes ◽  
In Vivo Detection ◽  
Chronic Oxidative Stress ◽  
Base Excision ◽  
Base Excision Dna Repair ◽  
Repair Genes

scholarly journals Expression of Base Excision DNA Repair Genes Is a Sensitive Biomarker for in Vivo Detection of Chemical-induced Chronic Oxidative Stress

2004 ◽  
Vol 64 (3) ◽  
pp. 1050-1057 ◽  
Author(s):  
Ivan Rusyn ◽  
Shoji Asakura ◽  
Brian Pachkowski ◽  
Blair U. Bradford ◽  
Mikhail F. Denissenko ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Repair ◽  
Dna Repair Genes ◽  
In Vivo Detection ◽  
Chronic Oxidative Stress ◽  
Base Excision ◽  
Base Excision Dna Repair ◽  
Repair Genes

Polymorphisms in base excision DNA repair genes and association with melanoma risk in a pilot study on Central-South Italian population

2012 ◽  
Vol 413 (19-20) ◽  
pp. 1519-1524 ◽  
Author(s):  
Concetta Santonocito ◽  
Margherita Scapaticci ◽  
Romina Penitente ◽  
Andrea Paradisi ◽  
Rodolfo Capizzi ◽  
...  
Keyword(s):  
Dna Repair ◽  
Pilot Study ◽  
Italian Population ◽  
Dna Repair Genes ◽  
Melanoma Risk ◽  
Base Excision ◽  
Base Excision Dna Repair ◽  
Repair Genes ◽  
Central South

Expression of base excision DNA repair genes as a biomarker of oxidative DNA damage

2005 ◽  
Vol 229 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Christine L. Powell ◽  
James A. Swenberg ◽  
Ivan Rusyn
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Oxidative Dna Damage ◽  
Dna Repair Genes ◽  
Base Excision ◽  
Base Excision Dna Repair ◽  
Repair Genes

scholarly journals Expression of DNA repair and metabolic genes in response to a flavonoid-rich diet

2007 ◽  
Vol 98 (3) ◽  
pp. 525-533 ◽  
Author(s):  
Simonetta Guarrera ◽  
Carlotta Sacerdote ◽  
Laura Fiorini ◽  
Rosa Marsala ◽  
Silvia Polidoro ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Repair ◽  
Significant Negative Correlation ◽  
Dna Repair Genes ◽  
Metabolic Genes ◽  
Damage Repair ◽  
Flavonoid Intake ◽  
Repair Mechanisms ◽  
Repair Genes

A diet rich in fruit and vegetables can be effective in the reduction of oxidative stress, through the antioxidant effects of phytochemicals and other mechanisms. Protection against the carcinogenic effects of chemicals may also be exerted by an enhancement of detoxification and DNA damage repair mechanisms. To investigate a putative effect of flavonoids, a class of polyphenols, on the regulation of the gene expression of DNA repair and metabolic genes, a 1-month flavonoid-rich diet was administered to thirty healthy male smokers, nine of whom underwent gene expression analysis. We postulated that tobacco smoke is a powerful source of reactive oxygen species. The expression level of twelve genes (APEX, ERCC1, ERCC2, ERCC4, MGMT, OGG1, XPA, XPC, XRCC1, XRCC3, AHR, CYP1A1) was investigated. We found a significant increase (P < 0·001) in flavonoid intake. Urinary phenolic content and anti-mutagenicity did not significantly change after diet, nor was a correlation found between flavonoid intake and urinary phenolic levels or anti-mutagenicity. Phenolic levels showed a significant positive correlation with urinary anti-mutagenicity. AHR levels were significantly reduced after the diet (P = 0·038), whereas the other genes showed a generalized up regulation, significant for XRCC3 gene (P = 0·038). Also in the context of a generalized up regulation of DNA repair genes, we found a non-significant negative correlation between flavonoid intake and the expression of all the DNA repair genes. Larger studies are needed to clarify the possible effects of flavonoids in vivo; our preliminary results could help to better plan new studies on gene expression and diet.

scholarly journals Implication of p53 in base excision DNA repair: in vivo evidence

Oncogene ◽  
2002 ◽  
Vol 21 (5) ◽  
pp. 731-737 ◽  
Author(s):  
Young R Seo ◽  
Melissa L Fishel ◽  
Sally Amundson ◽  
Mark R Kelley ◽  
Martin L Smith
Keyword(s):  
Dna Repair ◽  
Base Excision ◽  
Base Excision Dna Repair

scholarly journals Lead Induces Genotoxicity via Oxidative Stress and Promoter Methylation of DNA Repair Genes in Human Lymphoblastoid TK6 Cells

2018 ◽  
Vol 24 ◽  
pp. 4295-4304 ◽  
Author(s):  
Xiangquan Liu ◽  
Jingying Wu ◽  
Wenyan Shi ◽  
Wenhua Shi ◽  
Hekun Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Repair ◽  
Promoter Methylation ◽  
Dna Repair Genes ◽  
Methylation Of Dna ◽  
Tk6 Cells ◽  
Repair Genes

Targeting DNA Repair Systems in Antitubercular Drug Development

2019 ◽  
Vol 26 (8) ◽  
pp. 1494-1505 ◽  
Author(s):  
Alina Minias ◽  
Anna Brzostek ◽  
Jarosław Dziadek
Keyword(s):  
Dna Repair ◽  
Protein Crystal ◽  
Model Organisms ◽  
Dna Repair Genes ◽  
Associated Proteins ◽  
Related Proteins ◽  
Repair Genes

Infections with Mycobacterium tuberculosis, the causative agent of tuberculosis, are difficult to treat using currently available chemotherapeutics. Clinicians agree on the urgent need for novel drugs to treat tuberculosis. In this mini review, we summarize data that prompts the consideration of DNA repair-associated proteins as targets for the development of new antitubercular compounds. We discuss data, including gene expression data, that highlight the importance of DNA repair genes during the pathogenic cycle as well as after exposure to antimicrobials currently in use. Specifically, we report experiments on determining the essentiality of DNA repair-related genes. We report the availability of protein crystal structures and summarize discovered protein inhibitors. Further, we describe phenotypes of available gene mutants of M. tuberculosis and model organisms Mycobacterium bovis and Mycobacterium smegmatis. We summarize experiments regarding the role of DNA repair-related proteins in pathogenesis and virulence performed both in vitro and in vivo during the infection of macrophages and animals. We detail the role of DNA repair genes in acquiring mutations, which influence the rate of drug resistance acquisition.

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