Triphenylphosphine Catalized Reaction Between 1,3-Dicarbonyl Compounds and Acetylenic Esters

2003 ◽  
Vol 178 (12) ◽  
pp. 2627-2638 ◽  
Author(s):  
Issa Yavari ◽  
Farough Nasiri ◽  
Hoorih Djahaniani
Keyword(s):  
Acetylenic Esters ◽  
Dicarbonyl Compounds

scholarly journals Simple and one-pot synthesis of new heterocyclic compounds in three-component reactions between isoquinoline or phenanthridine and acetylenic esters in the presence of N-heterocycles or 1,3-dicarbonyl compounds

ARKIVOC ◽  
2010 ◽  
Vol 2010 (2) ◽  
pp. 61-70 ◽  
Author(s):  
Malek Taher Maghsoodlou ◽  
Mahmoud Nassiri ◽  
Reza Heydari ◽  
Nourollah Hazeri ◽  
Sayyed Mostafa Habibi-Khorassani ◽  
...  
Keyword(s):  
Heterocyclic Compounds ◽  
Acetylenic Esters ◽  
One Pot ◽  
Dicarbonyl Compounds ◽  
One Pot Synthesis

scholarly journals γ-Dispiro-iminolactone synthesis by three component reaction between alkyl isocyanides and acetylenic esters with α-dicarbonyl compounds

ARKIVOC ◽  
2007 ◽  
Vol 2007 (13) ◽  
pp. 34-40 ◽  
Author(s):  
Nourollah Hazeri ◽  
Malek Taher Maghsoodlou ◽  
Sayyed Mostafa Habibi-Khorassani ◽  
Morteza Ziyaadini ◽  
Ghasem Marandi ◽  
...  
Keyword(s):  
Acetylenic Esters ◽  
Dicarbonyl Compounds ◽  
Alkyl Isocyanides ◽  
Three Component Reaction

γ‐Spiroiminolactone Synthesis by Reaction of Acetylenic Esters and α‐Dicarbonyl Compounds in the Presence of Aryl Isocyanide

2005 ◽  
Vol 35 (21) ◽  
pp. 2771-2777 ◽  
Author(s):  
Malek T. Maghsoodlou ◽  
Nourollah Hazeri ◽  
Sayyed M. Habibi‐Khorasani ◽  
Ghasem Marandi ◽  
Mahmoud Nassiri
Keyword(s):  
Acetylenic Esters ◽  
Dicarbonyl Compounds

γ-Spiroiminolactone Synthesis by Reaction of Acetylenic Esters and α-Dicarbonyl Compounds in the Presence of Aryl Isocyanide.

ChemInform ◽  
2006 ◽  
Vol 37 (15) ◽  
Author(s):  
Malek T. Maghsoodlou ◽  
Nourollah Hazeri ◽  
Sayyed M. Habibi-Khorasani ◽  
Ghasem Marandi ◽  
Mahmoud Nassiri
Keyword(s):  
Acetylenic Esters ◽  
Dicarbonyl Compounds

Dicarbonyl derived post-translational modifications: chemistry bridging biology and aging-related disease

2020 ◽  
Vol 64 (1) ◽  
pp. 97-110
Author(s):  
Christian Sibbersen ◽  
Mogens Johannsen
Keyword(s):  
Mass Spectrometry ◽  
Future Research ◽  
Amino Acid Residues ◽  
Post Translational Modification ◽  
Dicarbonyl Compounds ◽  
Protein Targets ◽  
Post Translational Modifications ◽  
Reactive Protein ◽  
Glycation End Products ◽  
Direct Mass Spectrometry

Abstract In living systems, nucleophilic amino acid residues are prone to non-enzymatic post-translational modification by electrophiles. α-Dicarbonyl compounds are a special type of electrophiles that can react irreversibly with lysine, arginine, and cysteine residues via complex mechanisms to form post-translational modifications known as advanced glycation end-products (AGEs). Glyoxal, methylglyoxal, and 3-deoxyglucosone are the major endogenous dicarbonyls, with methylglyoxal being the most well-studied. There are several routes that lead to the formation of dicarbonyl compounds, most originating from glucose and glucose metabolism, such as the non-enzymatic decomposition of glycolytic intermediates and fructosyl amines. Although dicarbonyls are removed continuously mainly via the glyoxalase system, several conditions lead to an increase in dicarbonyl concentration and thereby AGE formation. AGEs have been implicated in diabetes and aging-related diseases, and for this reason the elucidation of their structure as well as protein targets is of great interest. Though the dicarbonyls and reactive protein side chains are of relatively simple nature, the structures of the adducts as well as their mechanism of formation are not that trivial. Furthermore, detection of sites of modification can be demanding and current best practices rely on either direct mass spectrometry or various methods of enrichment based on antibodies or click chemistry followed by mass spectrometry. Future research into the structure of these adducts and protein targets of dicarbonyl compounds may improve the understanding of how the mechanisms of diabetes and aging-related physiological damage occur.

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