Proliferative activity in the cerebellar external granular layer evaluated by bromodeoxyuridine labeling

2002 ◽  
Vol 77 (1) ◽  
pp. 27-35 ◽  
Author(s):  
JP Hervás ◽  
J. Martí-Clúa ◽  
A. Muñoz-García ◽  
MC Santa-Cruz
Keyword(s):  
Proliferative Activity ◽  
Granular Layer ◽  
External Granular Layer

Proliferative activity in the cerebellar external granular layer evaluated by bromodeoxyuridine labeling

2002 ◽  
Vol 77 (1) ◽  
pp. 27-35 ◽  
Author(s):  
JP Hervás ◽  
J Martí-Clúa ◽  
A Muñoz-García ◽  
MC Santa-Cruz
Keyword(s):  
Proliferative Activity ◽  
Granular Layer ◽  
External Granular Layer

Effect of Reserpine on the Differentiation of the External Granular Layer of the Cerebellum in the Chick Embryo

1987 ◽  
Vol 129 (4) ◽  
pp. 265-269 ◽  
Author(s):  
A. Espinar ◽  
A. Quesada ◽  
M. Martinez-de-la-Torre ◽  
J.A. Armengol
Keyword(s):  
Chick Embryo ◽  
Granular Layer ◽  
External Granular Layer

scholarly journals Prenatal treatment with metronidazole induces cerebellar folia alteration in guinea pig fetuses

2020 ◽  
Vol 72 (4) ◽  
pp. 473-482
Author(s):  
Ivan Capo ◽  
Ivan Milenkovic ◽  
Natasa Capo ◽  
Nebojsa Stilinovic ◽  
Sasa Vukmirovic ◽  
...  
Keyword(s):  
Animal Studies ◽  
Granular Layer ◽  
Molecular Layer ◽  
Sensitive Period ◽  
Insufficient Data ◽  
Prenatal Treatment ◽  
External Granular Layer ◽  
Areal Fraction ◽  
Experimental Group ◽  
Partial Atrophy

The most sensitive period in brain development is during prenatal life. The use of antibiotics in pregnancy is still controversial. Recent studies revealed the high neurotoxic potential of the antibiotic and antiprotozoal medication, metronidazole. However, there are insufficient data from animal studies about prenatal treatment effects. We investigated the effect of prenatal treatment with metronidazole on cerebellar development in guinea pigs. Treatment with metronidazole was performed from the 42nd to the 49th day of gestation. On the 50th day of pregnancy, all dams were killed, and the cerebella of the fetuses were analyzed. Gross cerebellar changes characterized by malposition of the folia with partial atrophy were found in 12 of 19 fetuses in the experimental group, but in none of 20 control fetuses that received saline. The most affected were folia VII with depletion of the areal fraction of the external granular layer, molecular layer and the internal granular layer. Purkinje cells displayed cell distortion with loss of normal dendritic polarity. The investigation revealed cell depletion, with a disturbance of the cytoarchitectonic of the cerebellar cortex and folia alteration.

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