scholarly journals EXPRESSION OF BCL-2 AND BAX IN RHESUS MONKEY TESTIS DURING GERM CELL APOPTOSIS INDUCED BY TESTOSTERONE UNDECANOATE

2003 ◽  
Vol 49 (6) ◽  
pp. 439-447 ◽  
Author(s):  
Z. -H. Zhang ◽  
X. -C. Zhou ◽  
P. Wei ◽  
Z. -Y. Hu ◽  
Y. -X. Liu
Keyword(s):  
Rhesus Monkey ◽  
Germ Cell ◽  
Cell Apoptosis ◽  
Testosterone Undecanoate ◽  
Germ Cell Apoptosis

scholarly journals EXPRESSION OF BCL-2 AND BAX IN RHESUS MONKEY TESTIS DURING GERM CELL APOPTOSIS INDUCED BY TESTOSTERONE UNDECANOATE

2003 ◽  
Vol 49 (6) ◽  
pp. 439-447 ◽  
Author(s):  
Z.-H. ZHANG ◽  
X.-C. ZHOU ◽  
P. WEI ◽  
Z.-Y. HU ◽  
Y.-X. LIU
Keyword(s):  
Rhesus Monkey ◽  
Germ Cell ◽  
Cell Apoptosis ◽  
Testosterone Undecanoate ◽  
Germ Cell Apoptosis

Expression of Hsp70–2 in rhesus monkey testis during germ cell apoptosis induced by testosterone undecanoate

Contraception ◽  
2002 ◽  
Vol 66 (5) ◽  
pp. 377-382 ◽  
Author(s):  
Xin-Chang Zhou ◽  
Zhi-Hong Zhang ◽  
Zhao-Yuan Hu ◽  
Ru-Jin Zou ◽  
Yi-Xun Liu
Keyword(s):  
Rhesus Monkey ◽  
Germ Cell ◽  
Cell Apoptosis ◽  
Testosterone Undecanoate ◽  
Germ Cell Apoptosis

Bcl-2 and Bax are involved in experimental cryptorchidism-induced testicular germ cell apoptosis in rhesus monkey

Contraception ◽  
2003 ◽  
Vol 68 (4) ◽  
pp. 297-301 ◽  
Author(s):  
Zhi-Hong Zhang ◽  
Xuan Jin ◽  
Xue-Sen Zhang ◽  
Zhao-Yuan Hu ◽  
Ru-Jin Zou ◽  
...  
Keyword(s):  
Rhesus Monkey ◽  
Germ Cell ◽  
Cell Apoptosis ◽  
Testicular Germ Cell ◽  
Germ Cell Apoptosis

scholarly journals Transient Scrotal Hyperthermia and Levonorgestrel Enhance Testosterone-Induced Spermatogenesis Suppression in Men through Increased Germ Cell Apoptosis

2007 ◽  
Vol 92 (8) ◽  
pp. 3292-3304 ◽  
Author(s):  
Christina Wang ◽  
Yu-Gui Cui ◽  
Xing-Hai Wang ◽  
Yue Jia ◽  
Amiya Sinha Hikim ◽  
...  
Keyword(s):  
Heat Treatment ◽  
Cell Death ◽  
Germ Cell ◽  
Outcome Measures ◽  
Cell Apoptosis ◽  
Heat Exposure ◽  
Continuous Treatment ◽  
Semen Parameters ◽  
Testosterone Undecanoate ◽  
Germ Cell Apoptosis

Abstract Context: In rodents and monkeys, a combination of hormonal and physical agents accelerates germ cell death. Objective: A “proof of concept” study was performed to investigate whether addition of heat exposure or a progestin to an androgen induces germ cell death and more complete and rapid spermatogenesis suppression. Design and Settings: A randomized clinical trial was performed at academic medical centers. Participants: We treated four groups of healthy male volunteers (18 per group) for 18 wk: 1) testosterone undecanoate (TU) 1000 mg im (first dose), followed by 500 mg im every 6 wk; 2) submersion of scrota at 43 C in water for 30 min/d for 6 consecutive days; 3) TU plus heat; and 4) TU plus oral levonorgestrel (LNG) 250 μg/d. Main Outcome Measures: Semen parameters, testicular histology, and germ cell apoptosis were the main outcome measures. Results: Heat alone and TU plus heat suppressed sperm counts more than TU alone by wk 6. By wk 9, recovery began in the heat only group, whereas spermatogenesis remained suppressed in the TU plus heat group. Oral LNG plus TU suppressed spermatogenesis earlier and more severely than TU alone. At wk 2, significantly greater germ cell apoptosis occurred in heat and heat plus TU subjects, but not in subjects without heat treatment, compared with pretreatment subjects. By 9 wk, markedly smaller seminiferous tubule diameters and fewer spermatocytes and spermatids were noted in all 12 biopsies from men receiving TU, TU plus LNG, with most dramatic differences for the TU plus heat group, whereas no differences from pretreatment biopsies were observed in men who received heat treatment only. Conclusions: Heat causes a rapid and transient suppression of spermatogenesis. TU plus heat resulted in low-sperm output that was maintained by continuous treatment with TU. Addition of an oral progestin accelerated spermatogenesis suppression by TU alone. Increased germ cell apoptosis contributed to suppression of spermatogenesis.

Expression of Hsp70-2 in Unilateral Cryptorchid Testis of Rhesus Monkey During Germ Cell Apoptosis

Endocrine ◽  
2001 ◽  
Vol 16 (2) ◽  
pp. 089-096 ◽  
Author(s):  
Xin-Chang Zhou ◽  
Xiao-Bin Han ◽  
Zhao-Yuan Hu ◽  
Ru-Jin Zhou ◽  
Yi-Xun Liu
Keyword(s):  
Rhesus Monkey ◽  
Germ Cell ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis ◽  
Cryptorchid Testis

scholarly journals TheCaenorhabditis elegans ing-3Gene Regulates Ionizing Radiation-Induced Germ-Cell Apoptosis in a p53-Associated Pathway

Genetics ◽  
2008 ◽  
Vol 181 (2) ◽  
pp. 473-482 ◽  
Author(s):  
Jingjing Luo ◽  
Sitar Shah ◽  
Karl Riabowol ◽  
Paul E. Mains
Keyword(s):  
Ionizing Radiation ◽  
Germ Cell ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis ◽  
Radiation Induced

Minocycline up-regulates BCL-2 levels in mitochondria and attenuates male germ cell apoptosis

2005 ◽  
Vol 337 (2) ◽  
pp. 663-669 ◽  
Author(s):  
Mark Castanares ◽  
Yanira Vera ◽  
Krista Erkkilä ◽  
Sauli Kyttänen ◽  
Yanhe Lue ◽  
...  
Keyword(s):  
Germ Cell ◽  
Cell Apoptosis ◽  
Male Germ Cell ◽  
Germ Cell Apoptosis
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