Micronized Purified Flavonoid Fraction and the Treatment of Chronic Venous Insufficiency: Microcirculatory Mechanisms

2000 ◽  
Vol 7 (6) ◽  
pp. 35-40 ◽  
Author(s):  
Philip D. Coleridge Smith
Keyword(s):  
Chronic Venous Insufficiency ◽  
Venous Insufficiency ◽  
Micronized Purified Flavonoid Fraction ◽  
Flavonoid Fraction

scholarly journals Modern view on the therapy of chronic venous insufficiency with micronized purified flavonoid fraction

2020 ◽  
Vol 19 (4) ◽  
pp. 2592
Author(s):  
H. M. Kurginyan ◽  
V. V. Raskin
Keyword(s):  
Pharmaceutical Industry ◽  
Chronic Venous Insufficiency ◽  
Venous Insufficiency ◽  
Population Studies ◽  
Varicose Veins ◽  
Venous Diseases ◽  
High Prevalence ◽  
Important Direction ◽  
Micronized Purified Flavonoid Fraction ◽  
Flavonoid Fraction

The high prevalence of varicose veins has been established in numerous population studies. Currently, guidelines have been developed for the treatment of patients with varicose veins for various stages of chronic venous insufficiency. Nevertheless, despite the use of modern drugs, leg compression, surgical and other interventions, it is not possible to completely reverse the symptoms of venous insufficiency. The article is devoted to the analysis of micronized flavonoid purified fraction. The development of modern drugs for chronic venous diseases is an important direction in medicine. The creation of a drug pool manufactured InRussiais a priority in the development of the country’s pharmaceutical industry. The review presents data on the study of Detravenol (Russia), which is a combination of diosmin and hesperidin (micronized purified flavonoid fraction).

scholarly journals Management of chronic venous insufficiency of the lower extremities

2018 ◽  
pp. 36-41
Author(s):  
M. N. Kudykin
Keyword(s):  
Mechanism Of Action ◽  
Chronic Venous Insufficiency ◽  
Venous Insufficiency ◽  
Clinical Manifestations ◽  
Lower Extremities ◽  
Venous Diseases ◽  
Micronized Purified Flavonoid Fraction ◽  
Flavonoid Fraction

The article presents up-to-date information about epidemiology, pathogenesis and clinical manifestations of chronic venous diseases and chronic venous insufficiency of the lower extremities. It discusses the mechanism of action of various phlebotrophic drugs intended for the treatment of symptoms of chronic venous diseases and chronic venous insufficiency and describes the advantages of micronized purified flavonoid fraction for the treatment of all clinical classes of chronic venous diseases.

scholarly journals Varicose Vein And Ecchymosis: A Case Report

10.3823/2508 ◽  
2017 ◽  
Vol 10 ◽  
Author(s):  
Ertan Yetkin ◽  
Selçuk Öztürk ◽  
Mehmet ILeri
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Clinical Practice ◽  
Female Patient ◽  
Varicose Vein ◽  
Chronic Venous Insufficiency ◽  
Venous Insufficiency ◽  
Lower Extremities ◽  
Micronized Purified Flavonoid Fraction ◽  
Flavonoid Fraction

Assessment of varicose vein and chronic venous insufficiency and making a differential diagnosis in patients suffering from a variety of sign and symptoms is sometimes a big challenge in daily clinical practice. Here, we present a female patient with varicose vein symptoms and ecchymosis on her lower extremities. Several irregular shaped ecchymotic lesions on both extremities in different stage of healing with deep purple have been treated by using micronized purified flavonoid fraction.

Therapeutic equivalence of two dosage forms of a micronized flavonoid fraction in patients with chronic venous insufficiency

1996 ◽  
Vol 57 (10) ◽  
pp. 757-766 ◽  
Author(s):  
Henri Boccalon ◽  
Catherine Salvadori ◽  
Dominique Benedittini ◽  
Dominique Steru ◽  
Claire Vilain
Keyword(s):  
Chronic Venous Insufficiency ◽  
Venous Insufficiency ◽  
Dosage Forms ◽  
Therapeutic Equivalence ◽  
Flavonoid Fraction

The Beneficial Augmentative Effect of Micronised Purified Flavonoid Fraction (MPFF) on the Healing of Leg Ulcers: An Open, Multicentre, Controlled, Randomised Study

1999 ◽  
Vol 14 (4) ◽  
pp. 151-157 ◽  
Author(s):  
W. Gliński ◽  
B. Chodynicka ◽  
J. Roszkiewicz ◽  
T. Bogdanowski ◽  
B. Lecewicz-Toruń ◽  
...  
Keyword(s):  
Chronic Venous Insufficiency ◽  
Venous Insufficiency ◽  
Venous Ulcer ◽  
Control Group ◽  
Cure Rate ◽  
Randomised Study ◽  
Venous Ulcers ◽  
The Mean ◽  
Flavonoid Fraction ◽  
The Cost

Objective: To determine the increase in healing rate of venous ulcer in patients receiving a micronised purified flavonoid fraction (MPFF) as supplementation to standard local care. Design: A randomised, open, controlled, multicentre study. Setting: Departments of Dermatology and University Outpatients Clinics. Patients: One hundred and forty patients with chronic venous insufficiency and venous ulcers. Intervention: Patients received standard compressive therapy plus external treatment alone or 2 tablets of MPFF daily in addition to the above treatment for 24 weeks. Main outcome measure: Healing of ulcers and their reduction in size after 24 weeks of treatment. Results: The percentage of patients whose ulcers healed completely was found to be markedly higher in those receiving MPFF in addition to standard external and compressive treatment than in those treated with conventional therapy alone (46.5% vs 27.5%; p<0.05, OR = 2.3, 95% CI 1.1–4.6). Ulcers with diameters <3 cm were cured in 71% of patients in the MPFF group and in 50% of patients in the control group, whereas ulcers between 3 and 6 cm in diameter were cured in 60% and 32% of patients ( p<0.05), respectively. The mean reduction in ulcer size was also found to be greater in patients treated with MPFF (80%) than in the control group (65%) ( p<0.05). The cost-effectiveness ratio (cost per healed ulcer) in the MPFF group was €1026.2 compared with €1871.8 in the control group. Conclusions: These results indicate that MPFF significantly improves the cure rate in patients with chronic venous insufficiency.

Long-term treatment of chronic venous insufficiency of the leg with micronized purified flavonoid fraction in the primary care setting of India

2004 ◽  
Vol 19 (4) ◽  
pp. 179-184 ◽  
Author(s):  
R K Pinjala ◽  
T K Abraham ◽  
S K Chadha ◽  
A A Hai ◽  
S A Hussain ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Primary Care ◽  
Venous Insufficiency ◽  
Care Setting ◽  
Primary Care Setting ◽  
Compression Stockings ◽  
Symptom Intensity ◽  
Micronized Purified Flavonoid Fraction ◽  
Flavonoid Fraction

Objective: This study investigates whether micronized purified flavonoid fraction (MPFF) is effective and acceptable without compression or surgical intervention for the management of chronic venous insufficiency of the leg (CVIL) in the primary care setting of a tropical country such as India. Methods: A prospective observational study on patients with early CVIL drawn from the clinical practice of randomly selected physicians distributed across India. Patients received MPFF 1000 mg/day for six months without compression stockings or surgery. The primary outcome was a change in their CEAP (clinical, aetiological, anatomical, pathophysiological) classification of CVIL severity. Secondary outcomes were changes in leg oedema, symptom intensity and quality of life. Results: Of the 308 patients recruited by 72 physicians, 166 (53.9%, 95% confidence interval (CI) 48.3-59.5) had regression in the CEAP severity stage. Mean leg circumference in those with oedema decreased by 2 cm (95% CI 1.7-2.3, P <0.05). Patient-assessed mean percentage decrease in symptom intensity was 32.3 for cramps (28.9-35.7, P <0.01); 32.4 for heaviness (29.8-35.7, P <0.01); 28.2 for pain (25.6-30.8, P <0.01); and 21.5 for swelling (18.7-24.3, P <0.01). Quality of life improved by 21.7% (16.9-26.5, P <0.01) in the physical domains, 25.9% (20.8-31.0, P <0.01) in the social domains, and 19.2% (14.7-23.7, P <0.01) in the psychological domains. Conclusions: When used alone, MPFF was effective and acceptable for the management of CVIL in primary care. This may be useful in tropical climates where compliance with compression stockings is poor and access to surgery limited.

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