Use of Bone Morphogenetic Protein-2 and Dentin Matrix Protein-1 to Enhance the Osteointegration of the Onplant System

2003 ◽  
Vol 44 (1) ◽  
pp. 30-41 ◽  
Author(s):  
Ali Hassan ◽  
Carla Evans ◽  
A. Moneim Zaki ◽  
Anne George
Keyword(s):  
Bone Morphogenetic Protein ◽  
Matrix Protein ◽  
Bone Morphogenetic Protein 2 ◽  
Dentin Matrix Protein 1 ◽  
Dentin Matrix Protein ◽  
Morphogenetic Protein ◽  
Dentin Matrix

scholarly journals Bone Morphogenetic Protein-1/Tolloid-like Proteinases Process Dentin Matrix Protein-1

2003 ◽  
Vol 279 (2) ◽  
pp. 980-986 ◽  
Author(s):  
Barry M. Steiglitz ◽  
Melvin Ayala ◽  
Karthikeyan Narayanan ◽  
Anne George ◽  
Daniel S. Greenspan
Keyword(s):  
Bone Morphogenetic Protein ◽  
Matrix Protein ◽  
Dentin Matrix Protein 1 ◽  
Dentin Matrix Protein ◽  
Morphogenetic Protein ◽  
Dentin Matrix ◽  
Bone Morphogenetic Protein 1

scholarly journals Possible Involvement of Smad Signaling Pathways in Induction of Odontoblastic Properties in KN-3 Cells by Bone Morphogenetic Protein-2: A Growth Factor to Induce Dentin Regeneration

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Ayako Washio ◽  
Chiaki Kitamura ◽  
Takahiko Morotomi ◽  
Masamichi Terashita ◽  
Tatsuji Nishihara
Keyword(s):  
Signaling Pathways ◽  
Bone Morphogenetic Protein ◽  
Intracellular Signaling ◽  
Matrix Protein ◽  
Molecular Mechanisms ◽  
Bone Morphogenetic Protein 2 ◽  
Smad Signaling ◽  
Dentin Matrix Protein ◽  
Alp Activity ◽  
Morphogenetic Protein

We examined the effects of bone morphogenetic protein-2 (BMP-2) on growth, differentiation, and intracellular signaling pathways of odontoblast-like cells, KN-3 cells, to clarify molecular mechanisms of odontoblast differentiation during pulp regeneration process. After treatment with BMP-2, the cell morphology, growth, alkaline phosphatase (ALP) activity, and the activation and expression of BMP-induced intracellular signaling molecules, such as Smad1/5/8 and Smad6/7, as well as activities of dentin sialoprotein (DSP) and dentin matrix protein 1 (DMP1), were examined. BMP-2 had no effects on the morphology, growth, or ALP activity of KN-3 cells, whereas it induced the phosphorylation of Smad1/5/8 and expression of Smad6/7. BMP-2 also induced the expressions of DSP and DMP-1. Our results suggest that KN-3 cells may express an odontoblastic phenotype with the addition of BMP-2 through the activation of Smad signaling pathways.

scholarly journals Volumetric, Radiographic, and Histologic Analyses of Demineralized Dentin Matrix Combined with Recombinant Human Bone Morphogenetic Protein-2 for Ridge Preservation: A Prospective Randomized Controlled Trial in Comparison with Xenograft

2018 ◽  
Vol 8 (8) ◽  
pp. 1288 ◽  
Author(s):  
Gyu-Un Jung ◽  
Tae-Hyun Jeon ◽  
Mong-Hun Kang ◽  
In-Woong Um ◽  
In-Seok Song ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 2 ◽  
Ridge Preservation ◽  
Tissue Volume ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Dentin Matrix ◽  
Demineralized Dentin Matrix ◽  
Recombinant Human Bone ◽  
Demineralized Dentin

The aim of this study was to evaluate the clinical, volumetric, radiographic, and histologic aspects of autogenous demineralized dentin matrix (DDM) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) used for ridge preservation, compared to those of deproteinized bovine bone with collagen (DBBC). Following atraumatic extraction, the socket was filled with DBBC, DDM, or rhBMP-2/DDM. Scanned images of dental casts and cone beam computed tomographs (CBCT) were superimposed for the calculation of soft and hard tissue volume alteration. Preoperative and postoperative measurements of the height and width of the alveolar ridge were compared using CBCT images. After 4 months, bone specimens were harvested for histomorphometric assessment. Loss of hard and soft tissue volume occurred at 4 months after extraction and ridge preservation in all groups. No volumetric differences were detected among the three groups before and 4 months after ridge preservation. The reduction in the horizontal width at 5 mm was higher in the DBBC compared to the DDM. Histologically, approximately 40% newly formed bone was founded in rhBMP-2/DDM group. The autogenous dentin matrix used to fill the socket was as beneficial for ridge preservation as conventional xenografts. The combination of rhBMP-2 with dentin matrix also demonstrated appreciable volumetric stability and higher new bone formation compared to DDM alone and DBBC.

scholarly journals Dentin matrix protein 1 (DMP1) expression in developing human teeth

2009 ◽  
Vol 20 (5) ◽  
pp. 365-369 ◽  
Author(s):  
Elizabeth Ferreira Martinez ◽  
Luciana Alves Herdy da Silva ◽  
Cristiane Furuse ◽  
Ney Soares de Araújo ◽  
Vera Cavalcanti de Araújo
Keyword(s):  
Dental Pulp ◽  
Matrix Protein ◽  
Enamel Organ ◽  
Dentin Matrix Protein 1 ◽  
Tooth Formation ◽  
Dentinal Tubules ◽  
Dental Lamina ◽  
Dentin Matrix Protein ◽  
Dental Papilla ◽  
Dentin Matrix

Dentin matrix protein 1 (DMP1) is an acidic phosphoprotein that plays an important role in mineralized tissue formation by initiation of nucleation and modulation of mineral phase morphology. The purpose of the present study was to examine the immunoexpression of DMP1 in tooth germs of 7 human fetuses at different gestational ages (14, 16, 19, 20, 21, 23 and 24 weeks) comparing with completed tooth formation erupted teeth. The results showed the presence of DMP1 in the dental lamina, as well as in the cells of the external epithelium, stellate reticulum and stratum intermedium of the enamel organ. However, in the internal dental epithelium, cervical loop region and dental papilla some cells have not labeled for DMP1. In the crown stage, DMP1 was expressed in the ameloblast and odontoblast layer, as well as in the dentinal tubules of coronal dentin near the odontoblast area. Erupted teeth with complete tooth formation exhibited immunolabeling for DMP1 only in the dentinal tubules mainly close to the dental pulp. No staining was observed in the enamel, predentin or dental pulp matrix. DMP1 is present in all developing dental structures (dental lamina, enamel organ, dental papilla) presenting few immunoexpression variations, with no staining in mineralized enamel and dentin.

Transcriptional Regulation of Dentin Matrix Protein 1 (DMP1) by AP-1 (c-fos/c-jun) Factors

2002 ◽  
Vol 43 (2) ◽  
pp. 365-371 ◽  
Author(s):  
Karthikeyan Narayanan ◽  
Amsaveni Ramachandran ◽  
Jianjun Hao ◽  
Anne George
Keyword(s):  
Transcriptional Regulation ◽  
Matrix Protein ◽  
Dentin Matrix Protein 1 ◽  
Dentin Matrix Protein ◽  
Dentin Matrix

scholarly journals MP493LOW DENTIN MATRIX PROTEIN 1 IS ASSOCIATED WITH INCIDENT CARDIOVASCULAR EVENTS IN PERITONEAL DIALYSIS PATIENTS

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i505-i505
Author(s):  
Misol Lee ◽  
Changhwan Seo ◽  
Min-uk Cha ◽  
Hyoung Rae Kim ◽  
Hae-Ryong Yun ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Cardiovascular Events ◽  
Matrix Protein ◽  
Dentin Matrix Protein 1 ◽  
Dialysis Patients ◽  
Dentin Matrix Protein ◽  
Dentin Matrix
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