Polypeptides Translated From Alternatively Spliced Transcripts of the Amelogenin Gene, Devoid of the Exon 6a,b,c Region, Have Specific Effects on Tooth Germ Development in Culture

2002 ◽  
Vol 43 (2) ◽  
pp. 224-231 ◽  
Author(s):  
Kevin Tompkins ◽  
Arthur Veis
Keyword(s):  
Tooth Germ ◽  
Amelogenin Gene ◽  
Specific Effects ◽  
Tooth Germ Development ◽  
Alternatively Spliced

Disturbed tooth germ development in the absence of MINT in the cultured mouse mandibular explants

2010 ◽  
Vol 38 (2) ◽  
pp. 777-784 ◽  
Author(s):  
Ming-Hui Zhu ◽  
Wen-Bo Dong ◽  
Guang-Ying Dong ◽  
Ping Zhang ◽  
Yong-Jin Chen ◽  
...  
Keyword(s):  
Tooth Germ ◽  
Tooth Germ Development

The involvement of genes related to bile secretion pathway in rat tooth germ development

2020 ◽  
Vol 51 (1) ◽  
pp. 99-107
Author(s):  
Jun Yang ◽  
Xi Lu ◽  
Shangfeng Liu ◽  
Shouliang Zhao
Keyword(s):  
Tooth Germ ◽  
Bile Secretion ◽  
Secretion Pathway ◽  
Tooth Germ Development

scholarly journals Genotype and Tissue-Specific Effects on Alternative Splicing of the Transcription Factor 7-Like 2 Gene in Humans

2010 ◽  
Vol 95 (3) ◽  
pp. 1450-1457 ◽  
Author(s):  
Ashis K. Mondal ◽  
Swapan K. Das ◽  
Giulia Baldini ◽  
Winston S. Chu ◽  
Neeraj K. Sharma ◽  
...  
Keyword(s):  
Alternative Transcript ◽  
Nucleotide Polymorphisms ◽  
Specific Effects ◽  
Clinical Research Center ◽  
General Clinical Research Center ◽  
Increase Risk ◽  
Alternatively Spliced ◽  
Sgbs Cells ◽  
Splice Forms

Abstract Context: Noncoding single-nucleotide polymorphisms (SNPs) within the TCF7L2 gene are confirmed risk factors for type 2 diabetes, but the mechanism by which they increase risk is unknown. Objective: We hypothesized that associated SNPs alter TCF7L2 splicing and that splice forms have altered biological roles. Design: Splice forms and 5′ and 3′ untranslated regions were characterized in sc adipose, muscle, liver, HepG2 cells, pancreas, and islet. Isoform-specific transcript levels were quantified in sc adipose. Alternative splice forms were characterized in HepG2 liver cells under glucose and insulin conditions and in SGBS cells with differentiation. Major isoforms were characterized by transfection. Setting: The study was conducted at an ambulatory general clinical research center. Patients: Patients included 78 healthy, nondiabetic study subjects characterized for insulin sensitivity and secretion. Results: We identified 32 alternatively spliced transcripts and multiple-length 3′ untranslated region transcripts in adipose, muscle, islet, and pancreas. Alternative exons 3a, 12, 13, and 13a were observed in all tissues, whereas exon 13b was islet specific. Transcripts retaining exons 13 and 13a but not total TCF7L2 transcripts were significantly correlated with both obesity measures (P < 0.01) and rs7903146 genotype (P < 0.026) in sc adipose. Insulin (5–10 nm) suppressed all TCF7L2 isoforms in SGBS cells but suppressed exon 13a-containing isoforms most significantly (P < 0.001). The isoform distribution differed throughout SGBS cell differentiation. Isoforms with predicted early stop codons yielded stable proteins of the predicted size, bound β-catenin, and targeted correctly to the nucleus. Conclusions: Intronic TCF7L2 variants may regulate alternative transcript isoforms, which in turn may have distinct physiologic roles.

Type II/III Runx2/Cbfa1 is required for tooth germ development

Bone ◽  
2006 ◽  
Vol 38 (6) ◽  
pp. 836-844 ◽  
Author(s):  
Ieyoshi Kobayashi ◽  
Tamotsu Kiyoshima ◽  
Hiroko Wada ◽  
Kou Matsuo ◽  
Kazuaki Nonaka ◽  
...  
Keyword(s):  
Tooth Germ ◽  
Type Ii ◽  
Tooth Germ Development

scholarly journals TGF-beta3 induces ectopic mineralization in fetal mouse dental pulp during tooth germ development

2005 ◽  
Vol 47 (3) ◽  
pp. 141-152 ◽  
Author(s):  
Muhetaer Huojia ◽  
Noriko Muraoka ◽  
Keigo Yoshizaki ◽  
Satoshi Fukumoto ◽  
Misako Nakashima ◽  
...  
Keyword(s):  
Dental Pulp ◽  
Tooth Germ ◽  
Fetal Mouse ◽  
Ectopic Mineralization ◽  
Tooth Germ Development

scholarly journals The expression of RANKL, OPG and TNF-α on cells and/or tissues around alveolar bone during early-stage rat tooth germ development

2011 ◽  
Vol 15 (2) ◽  
pp. 39-43
Author(s):  
Fumiko Fukuhara ◽  
Kenichi Matsuzaka ◽  
Sachie Senzui ◽  
Seikou Shintani ◽  
Takashi Inoue
Keyword(s):  
Alveolar Bone ◽  
Early Stage ◽  
Tooth Germ ◽  
Tnf Α ◽  
Tooth Germ Development

scholarly journals Distribution of Cathepsin K in Late Stage of Tooth Germ Development and Its Function in Degrading Enamel Matrix Proteins in Mouse

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0169857 ◽  
Author(s):  
Tao Jiang ◽  
Fen Liu ◽  
Wei-Guang Wang ◽  
Xin Jiang ◽  
Xuan Wen ◽  
...  
Keyword(s):  
Late Stage ◽  
Cathepsin K ◽  
Tooth Germ ◽  
Matrix Proteins ◽  
Enamel Matrix ◽  
Enamel Matrix Proteins ◽  
Tooth Germ Development
Sign in / Sign up

Export Citation Format

Share Document