The effect of oral versus vaginal misoprostol on cervical dilatation in first-trimester abortion: a double-blind, randomized study

2003 ◽  
Vol 8 (4) ◽  
pp. 197-202
Author(s):  
M. M. Inal ◽  
K. Ertopçu ◽  
A. Arici ◽  
I. Özelmas
Keyword(s):  
Randomized Study ◽  
First Trimester ◽  
Cervical Dilatation ◽  
Double Blind ◽  
Trimester Abortion ◽  
Vaginal Misoprostol

Evaluation of the effectiveness of vaginal misoprostol to induce first trimester abortion

Contraception ◽  
1996 ◽  
Vol 53 (4) ◽  
pp. 243-246 ◽  
Author(s):  
A. Bugalho ◽  
A. Faúndes ◽  
L. Jamisse ◽  
M. Usfá ◽  
E. Maria ◽  
...  
Keyword(s):  
First Trimester ◽  
Trimester Abortion ◽  
Vaginal Misoprostol

scholarly journals Comparison of efficacy of buccal versus vaginal misoprostol in first trimester induced abortion

2019 ◽  
Vol 8 (8) ◽  
pp. 3368
Author(s):  
Nida Khan ◽  
Anita M. Kant ◽  
Pooja C. Thukral ◽  
Mohammad Saquib
Keyword(s):  
Side Effects ◽  
Group Versus ◽  
First Trimester ◽  
Comparable Efficacy ◽  
P Value ◽  
Vaginal Route ◽  
Trimester Abortion ◽  
Group A ◽  
Vaginal Misoprostol ◽  
Group B

Background: To compare the effectiveness, side effects, and patient satisfaction of buccal versus vaginal misoprostol administration in first trimester abortions.Methods: Women opting for first trimester abortion received oral Mifepristone followed 48 hours latermisoprostol. Group A received Misoprostol via buccal route whereas group B received Misoprostol vaginally. A comparative analysis using SPSS was done.Results: Giving 800µg Misoprostol by either buccal or vaginal route after oral Mifepristone have comparable efficacy in terms of complete abortion rate (96% in buccal group versus 98% in vaginal group; p value = 0.495), failure rate being statistically similar (4% versus 2%). Drug abortion interval was comparable in the two groups. (11.16 hour in buccal group and 12.32 hours in vaginal group). Few side effects like nausea and vomiting, shivering, diarrohea was significantly higher with vaginal Misoprostol while abdominal cramps, altered taste were found more with the buccal group.Conclusions: Buccal Misoprostol is comfortable and easier to administer when compared to other routes and it has potential to be developed as a self-administered regimen. Buccal Misoprostol is as efficacious as vaginal Misoprostol with significantly lesser side effects up to 7 weeks of period of gestation.

Sublingual versus vaginal misoprostol (400 μg) for cervical priming in first-trimester abortion: a randomized trial

Contraception ◽  
2006 ◽  
Vol 74 (4) ◽  
pp. 328-333 ◽  
Author(s):  
Josep Lluis Carbonell Esteve ◽  
Jose Maria Marí ◽  
Francisco Valero ◽  
Margardel Llorente ◽  
Immaculada Salvador ◽  
...  
Keyword(s):  
Randomized Trial ◽  
First Trimester ◽  
Trimester Abortion ◽  
Cervical Priming ◽  
Vaginal Misoprostol

scholarly journals Comparative evaluation of two commonly administered regimens of mifepristone and misoprostol for first trimester abortion

2018 ◽  
Vol 7 (7) ◽  
pp. 2759
Author(s):  
L. Thulasi Devi ◽  
Ravi Nimonkar
Keyword(s):  
Side Effects ◽  
Tertiary Care Hospital ◽  
Randomized Study ◽  
Tertiary Care ◽  
First Trimester ◽  
Family Welfare ◽  
Care Hospital ◽  
Trimester Abortion ◽  
Misoprostol Group

Background: The objective of this study was to compare and evaluate the efficacy of two commonly administered regimens as per existing guidelines of Ministry of Health and Family Welfare for Outpatient MTP services. This study is aimed at evaluation of subjective and objective stastical benefits and side effects in performance of first trimester abortion on OPD basis in popularly used drugs as advised by MOHFW by different routes of administration. The drugs used were Tab Mifepristone (RU – 486) and Tab Misoprostol.Methods: This prospective randomized study was conducted in Out Patient Department of Obstetrics and Gynaecology in a tertiary care hospital over a period of 1 year after due clearance was obtained from Ethical Committee. This was prospective study involving 400 ladies reporting for Outpatient MTP services within the given time period as per existing guidelines at a tertiary care hospital. Patients were assessed at the end of 7, 15and 56 days, the mean age of the patients was 24.5±0.5 and 33±1 years and treatment duration was an average of 3 days with follow up for 15 days post administration. Few cases of failure required a follow up of approximately 56 days. All patients were on follow up for a period of 3 months for determination of menstrual irregularities and contraception management.Results: Between the 2 groups, in the sublingual Misoprostol group 100% aborted successfully at the end of 56 days. Whereas in the vaginal Misoprostol group 99% aborted successfully at the end of 56 days, only two patients requiring MVA as an OPD procedure.Conclusions: Patients were assessed at the end of 7, 15 and 56 days and between both the groups; Mifepristone with administration of misoprostol sublingually showed better success rate in completion of procedure, quicker action with better patient satisfaction and acceptance compared to conventional administration of Mifepristone and vaginal administration of misoprostol. Misoprostol administered sublingually under medical supervision is a superior, faster abortificient and has lesser incidence of Retained Products of Conception (RPOC) or need for Suction & Evacuation (S&E) as compared to vaginal route. Side effects observed need more evaluation with larger sample size to be statistically significant.

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