Interleukin-11 enhances cell survival of decidualized normal human endometrial stromal cells

2001 ◽  
Vol 15 (4) ◽  
pp. 272-278 ◽  
Author(s):  
T. Tanaka ◽  
T. Sakamoto ◽  
M. Miyama ◽  
S. Ogita ◽  
N. Umesaki
Keyword(s):  
Cell Survival ◽  
Stromal Cells ◽  
Endometrial Stromal Cells ◽  
Normal Human ◽  
Interleukin 11

Interleukin-11 enhances cell survival of decidualized normal human endometrial stromal cells

2001 ◽  
Vol 15 (4) ◽  
pp. 272-278 ◽  
Author(s):  
T. Tanaka ◽  
T. Sakamoto ◽  
M. Miyama ◽  
S. Ogita ◽  
N. Umesaki
Keyword(s):  
Cell Survival ◽  
Stromal Cells ◽  
Endometrial Stromal Cells ◽  
Normal Human ◽  
Interleukin 11

scholarly journals The Production of Interleukin-11 and Decidualization Are Compromised in Endometrial Stromal Cells Derived from Patients with Infertility

2005 ◽  
Vol 90 (3) ◽  
pp. 1607-1612 ◽  
Author(s):  
Natalia Karpovich ◽  
Petra Klemmt ◽  
Jung Hye Hwang ◽  
J. Enda McVeigh ◽  
John K. Heath ◽  
...  
Keyword(s):  
Stromal Cells ◽  
Endometrial Stromal Cells ◽  
Interleukin 11

Interleukin 1 beta is induced by interleukin 11 during decidualization of human endometrial stromal cells, but is not released in a bioactive form

2007 ◽  
Vol 73 (1) ◽  
pp. 28-38 ◽  
Author(s):  
Christine A. White ◽  
Evdokia Dimitriadis ◽  
Andrew M. Sharkey ◽  
Chelsea J. Stoikos ◽  
Lois A. Salamonsen
Keyword(s):  
Stromal Cells ◽  
Interleukin 1 ◽  
Interleukin 1 Beta ◽  
Endometrial Stromal Cells ◽  
Interleukin 11

scholarly journals Altered Retinoid Uptake and Action Contributes to Cell Survival in Endometriosis

2010 ◽  
Vol 95 (11) ◽  
pp. E300-E309 ◽  
Author(s):  
Mary Ellen Pavone ◽  
Scott Reierstad ◽  
Hui Sun ◽  
Magdy Milad ◽  
Serdar E. Bulun ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Progesterone Receptor ◽  
Cell Survival ◽  
Stromal Cells ◽  
Binding Protein ◽  
Peroxisome Proliferator ◽  
Endometrial Stromal Cells ◽  
Peroxisome Proliferator Activated Receptor ◽  
Fatty Acid Binding ◽  
Endometrial Cells

Context: Retinoic acid (RA) controls multiple biological processes via exerting opposing effects on cell survival. Retinol uptake into cells is controlled by stimulated by RA 6 (STRA6). RA is then produced from retinol in the cytosol. Partitioning of RA between the nuclear receptors RA receptor α and peroxisome-proliferator-activated receptor β/δ is regulated by cytosol-to-nuclear shuttling proteins cellular RA binding protein 2 (CRABP2) and fatty acid binding protein 5 (FABP5), which induce apoptosis or enhance survival, respectively. The roles of these mechanisms in endometrium or endometriosis remain unknown. Objective: The aim was to determine the regulation of retinoid uptake and RA action in primary stromal cells from endometrium (n = 10) or endometriosis (n = 10). Results: Progesterone receptor was necessary for high STRA6 and CRABP2 expression in endometrial stromal cells. STRA6, which was responsible for labeled retinoid uptake, was strikingly lower in endometriotic cells compared to endometrial cells. CRABP2 knockdown in endometrial cells increased survival, and FABP5 knockdown in endometriotic cells decreased survival without altering the expression of downstream nuclear retinoic acid receptor α and peroxisome-proliferator-activated receptor β/δ. Conclusions: In endometrial stromal cells, progesterone receptor up-regulates expression of STRA6 and CRABP2, which control retinol uptake and growth-suppressor actions of RA. In endometriotic stromal cells, decreased expression of these genes leads to decreased retinol uptake and dominant FABP5-mediated prosurvival activity.

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