Chronic abdominal pain in irritable bowel syndrome – current and future therapies

2018 ◽  
Vol 11 (7) ◽  
pp. 729-739 ◽  
Author(s):  
Anna Zielińska ◽  
Maciej Sałaga ◽  
Marcin Włodarczyk ◽  
Jakub Fichna
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Chronic Abdominal Pain ◽  
Irritable Bowel

scholarly journals Chronic Abdominal Pain: Not Always Irritable Bowel Syndrome

2006 ◽  
Vol 51 (6) ◽  
pp. 1049-1051 ◽  
Author(s):  
Stephan M. Wildi ◽  
Christoph Gubler ◽  
Michael Fried ◽  
Peter Bauerfeind ◽  
Dieter Hahnloser
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Chronic Abdominal Pain ◽  
Irritable Bowel

scholarly journals Thoracic Disk Herniation, a not Infrequent Cause of Chronic Abdominal Pain

2012 ◽  
Vol 97 (1) ◽  
pp. 27-33 ◽  
Author(s):  
F. J. Pérez Lara ◽  
A. Ferrer Berges ◽  
J. Quintero Quesada ◽  
J. A. Moreno Ramiro ◽  
R. Bustamante Toledo ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Correct Diagnosis ◽  
Spinal Column ◽  
Chronic Abdominal Pain ◽  
Disk Herniation ◽  
Irritable Bowel ◽  
Transversal Study ◽  
Possible Cause

Abstract This study assesses the proportion of patients presenting with nonvisceral chronic abdominal pain who have thoracic disk herniation as a possible cause. We designed a descriptive transversal study of patients attending our offices between February 2009 and October 2010, with a complaint of chronic abdominal pain of suspected abdominal wall source (positive Carnett sign). Nuclear magnetic resonance (NMR) of the spinal column was performed on all patients. When the NMR showed thoracic disk herniation the patients were treated according to their etiology. We also evaluated the symptoms in patients with thoracic disk herniation and their response to the applied treatment. Twenty-seven patients with chronic abdominal pain were evaluated. The NMR results in 18 of these 27 patients (66.66%) showed evidence of disk herniation. We report on the results of these 18 patients, emphasizing that the symptoms are florid and varied. Many patients had been previously diagnosed with irritable bowel syndrome. Thoracic disk herniation may account for chronic abdominal pain in many patients who remain undiagnosed or are diagnosed with irritable bowel syndrome. Thus, this possibility needs to be taken into account to achieve a correct diagnosis and a suitable mode of treatment.

Effectiveness of rifaximin in the treatment of abdominal pain at irritable bowel syndrome

2020 ◽  
Vol 0 (4) ◽  
pp. 22-28
Author(s):  
S. M. Tkach ◽  
A. E. Dorofeev ◽  
N. M. Mirzabaeva
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Irritable Bowel

scholarly journals Identification of potential biomarkers for abdominal pain in IBS patients by bioinformatics approach

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhongyuan Lin ◽  
Yimin Wang ◽  
Shiqing Lin ◽  
Decheng Liu ◽  
Guohui Mo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Gastrointestinal Disease ◽  
Rectal Mucosa ◽  
Interaction Network ◽  
Enrichment Analysis ◽  
Functional Enrichment ◽  
Irritable Bowel ◽  
Potential Biomarkers

Abstract Background Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disease characterized by chronic abdominal discomfort and pain. The mechanisms of abdominal pain, as a relevant symptom, in IBS are still unclear. We aimed to explore the key genes and neurobiological changes specially involved in abdominal pain in IBS. Methods Gene expression data (GSE36701) was downloaded from Gene Expression Omnibus database. Fifty-three rectal mucosa samples from 27 irritable bowel syndrome with diarrhea (IBS-D) patients and 40 samples from 21 healthy volunteers as controls were included. Differentially expressed genes (DEGs) between two groups were identified using the GEO2R online tool. Functional enrichment analysis of DEGs was performed on the DAVID database. Then a protein–protein interaction network was constructed and visualized using STRING database and Cytoscape. Results The microarray analysis demonstrated a subset of genes (CCKBR, CCL13, ACPP, BDKRB2, GRPR, SLC1A2, NPFF, P2RX4, TRPA1, CCKBR, TLX2, MRGPRX3, PAX2, CXCR1) specially involved in pain transmission. Among these genes, we identified GRPR, NPFF and TRPA1 genes as potential biomarkers for irritating abdominal pain of IBS patients. Conclusions Overexpression of certain pain-related genes (GRPR, NPFF and TRPA1) may contribute to chronic visceral hypersensitivity, therefore be partly responsible for recurrent abdominal pain or discomfort in IBS patients. Several synapses modification and biological process of psychological distress may be risk factors of IBS.

Sign in / Sign up

Export Citation Format

Share Document