Preparation and Structure of Chiral Two-component Molecular Crystals from 3-(3-Indolyl)propanoic Acid and Aza Aromatic Compounds

1999 ◽  
Vol 11 (1) ◽  
pp. 57-66 ◽  
Author(s):  
Hideko Koshima ◽  
Eiji Hayashi ◽  
Teruo Matsuura
Keyword(s):  
Aromatic Compounds ◽  
Molecular Crystals ◽  
Propanoic Acid ◽  
Two Component

ChemInform Abstract: Solid-State Photoreaction in Two-Component Molecular Crystals of Thienylacetic Acids and Aza Aromatic Compounds.

ChemInform ◽  
2000 ◽  
Vol 31 (48) ◽  
pp. no-no
Author(s):  
Hideko Koshima ◽  
Daisuke Matsushige ◽  
Masashi Miyauchi ◽  
Junko Fujita
Keyword(s):  
Solid State ◽  
Aromatic Compounds ◽  
Molecular Crystals ◽  
Two Component

Photoreaction in two-component molecular crystals of α-hydroxycarboxylic acids and aza aromatic compounds

1999 ◽  
Vol 129 (3) ◽  
pp. 121-128 ◽  
Author(s):  
H Koshima ◽  
E Hayashi ◽  
K Shirafuji ◽  
M Hamada ◽  
D Matsushige ◽  
...  
Keyword(s):  
Aromatic Compounds ◽  
Molecular Crystals ◽  
Hydroxycarboxylic Acids ◽  
Two Component

Solid-State Photoreaction in Two-Component Molecular Crystals of Thienylacetic Acids and Aza Aromatic Compounds

Tetrahedron ◽  
2000 ◽  
Vol 56 (36) ◽  
pp. 6845-6852 ◽  
Author(s):  
Hideko Koshima ◽  
Daisuke Matsushige ◽  
Masashi Miyauchi ◽  
Junko Fujita
Keyword(s):  
Solid State ◽  
Aromatic Compounds ◽  
Molecular Crystals ◽  
Two Component

Stoichiometrically Sensitized Decarboxylation Occurring in the Two-Component Molecular Crystals of Aza Aromatic Compounds and Aralkyl Carboxylic Acids

1997 ◽  
Vol 119 (43) ◽  
pp. 10317-10324 ◽  
Author(s):  
Hideko Koshima ◽  
Kuiling Ding ◽  
Yosuke Chisaka ◽  
Teruo Matsuura ◽  
Ikuko Miyahara ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Aromatic Compounds ◽  
Molecular Crystals ◽  
Two Component

Generation of Chirality in Two-Component Molecular Crystals of Tryptamine and Achiral Carboxylic Acids

1999 ◽  
Vol 64 (11) ◽  
pp. 3916-3921 ◽  
Author(s):  
Hideko Koshima ◽  
Shinji Honke ◽  
Junko Fujita
Keyword(s):  
Carboxylic Acids ◽  
Molecular Crystals ◽  
Two Component

scholarly journals A Novel Redox-Sensing Histidine Kinase That Controls Carbon Catabolite Repression inAzoarcussp. CIB

mBio ◽  
2019 ◽  
Vol 10 (2) ◽  
Author(s):  
J. Andrés Valderrama ◽  
Helena Gómez-Álvarez ◽  
Zaira Martín-Moldes ◽  
M. Álvaro Berbís ◽  
F. Javier Cañada ◽  
...  
Keyword(s):  
Aromatic Compounds ◽  
Histidine Kinase ◽  
Catabolite Repression ◽  
Carbon Catabolite Repression ◽  
Response Regulator ◽  
Sensor Kinase ◽  
General Role ◽  
Two Component ◽  
Redox Switch ◽  
Redox Sensing

ABSTRACTWe have identified and characterized the AccS multidomain sensor kinase that mediates the activation of the AccR master regulator involved in carbon catabolite repression (CCR) of the anaerobic catabolism of aromatic compounds inAzoarcussp. CIB. A truncated AccS protein that contains only the soluble C-terminal autokinase module (AccS′) accounts for the succinate-dependent CCR control. In vitroassays with purified AccS′ revealed its autophosphorylation, phosphotransfer from AccS′∼P to the Asp60 residue of AccR, and the phosphatase activity toward its phosphorylated response regulator, indicating that the equilibrium between the kinase and phosphatase activities of AccS′ may control the phosphorylation state of the AccR transcriptional regulator. Oxidized quinones, e.g., ubiquinone 0 and menadione, switched the AccS′ autokinase activity off, and three conserved Cys residues, which are not essential for catalysis, are involved in such inhibition. Thiol oxidation by quinones caused a change in the oligomeric state of the AccS′ dimer resulting in the formation of an inactive monomer. This thiol-based redox switch is tuned by the cellular energy state, which can change depending on the carbon source that the cells are using. This work expands the functional diversity of redox-sensitive sensor kinases, showing that they can control new bacterial processes such as CCR of the anaerobic catabolism of aromatic compounds. The AccSR two-component system is conserved in the genomes of some betaproteobacteria, where it might play a more general role in controlling the global metabolic state according to carbon availability.IMPORTANCETwo-component signal transduction systems comprise a sensor histidine kinase and its cognate response regulator, and some have evolved to sense and convert redox signals into regulatory outputs that allow bacteria to adapt to the altered redox environment. The work presented here expands knowledge of the functional diversity of redox-sensing kinases to control carbon catabolite repression (CCR), a phenomenon that allows the selective assimilation of a preferred compound among a mixture of several carbon sources. The newly characterized AccS sensor kinase is responsible for the phosphorylation and activation of the AccR master regulator involved in CCR of the anaerobic degradation of aromatic compounds in the betaproteobacteriumAzoarcussp. CIB. AccS seems to have a thiol-based redox switch that is modulated by the redox state of the quinone pool. The AccSR system is conserved in several betaproteobacteria, where it might play a more general role controlling their global metabolic state.

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