Genetic research on general cognitive ability as a model for mild mental retardation

1999 ◽  
Vol 11 (1) ◽  
pp. 34-46 ◽  
Author(s):  
ROBERT PLOMIN
Keyword(s):  
Mental Retardation ◽  
Cognitive Ability ◽  
Genetic Research ◽  
General Cognitive Ability ◽  
Mild Mental Retardation

scholarly journals Genetics, environment and cognitive abilities: review and work in progress towards a genome scan for quantitative trait locus associations using DNA pooling

2001 ◽  
Vol 178 (S40) ◽  
pp. s41-s48 ◽  
Author(s):  
Robert Plomin ◽  
Ian Craig
Keyword(s):  
Cognitive Ability ◽  
Dna Markers ◽  
Cognitive Abilities ◽  
Genetic Research ◽  
Allelic Association ◽  
General Cognitive Ability ◽  
Chromosome 4 ◽  
Dna Pooling ◽  
Systematic Analysis ◽  
A Genome

BackgroundMultivariate genetic research indicates that genetic effects on diverse cognitive abilities are general rather than specific or modular. General cognitive ability (g), a key factor in learning and memory, is among the most heritable behavioural traits.AimsTo give a brief overview of quantitative genetic research on g and to describe initial results from a programme of research that aims to identify genes responsible for the substantial heritability of general cognitive ability.MethodThe research uses a new technique called DNA pooling, which combines DNA from individuals within a group and makes it feasible to screen thousands of DNA markers for a systematic scan of the genome for associations between DNA markers and g. Two independent samples of children with very high g scores and two control samples of children with average g scores were compared in a systematic scan of 147 markers on chromosome 4 and 66 markers on chromosome 22.ResultsThree replicated associations on chromosome 4 were identified using DNA pooling and confirmed using individual genotyping.ConclusionsThese first results of the application of DNA pooling in systematic analysis of allelic association are encouraging.

Sex Differences in Childhood Associations between DNA Markers and General Cognitive Ability

2007 ◽  
Vol 28 (3) ◽  
pp. 161-164 ◽  
Author(s):  
Rosalind Arden ◽  
Nicole Harlaar ◽  
Robert Plomin
Keyword(s):  
Sex Differences ◽  
Single Nucleotide Polymorphisms ◽  
Cognitive Ability ◽  
Dna Markers ◽  
Community Sample ◽  
Nucleotide Polymorphisms ◽  
General Cognitive Ability ◽  
Single Nucleotide ◽  
The Difference

Abstract. An association between intelligence at age 7 and a set of five single-nucleotide polymorphisms (SNPs) has been identified and replicated. We used this composite SNP set to investigate whether the associations differ between boys and girls for general cognitive ability at ages 2, 3, 4, 7, 9, and 10 years. In a longitudinal community sample of British twins aged 2-10 (n > 4,000 individuals), we found that the SNP set is more strongly associated with intelligence in males than in females at ages 7, 9, and 10 and the difference is significant at 10. If this finding replicates in other studies, these results will constitute the first evidence of the same autosomal genes acting differently on intelligence in the two sexes.

Posture Control in Mild Mental Retardation

2003 ◽  
Author(s):  
Huh Jin-Young ◽  
Lee Jae-Won ◽  
Lee Chai-Hang
Keyword(s):  
Mental Retardation ◽  
Posture Control ◽  
Mild Mental Retardation

Hyperprolinemia type II as a differential diagnosis of mild mental retardation and seizures

2008 ◽  
Vol 39 (01) ◽  
Author(s):  
B Reulecke ◽  
T Stölting ◽  
J Sass ◽  
T Marquardt ◽  
G Kurlemann ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Mental Retardation ◽  
Type Ii ◽  
Mild Mental Retardation ◽  
Hyperprolinemia Type Ii
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