Sensitivity of neurons in somatosensory cortex (S1) to cutaneous stimulation of the hindlimb immediately following a sciatic nerve crush

1999 ◽  
Vol 16 (2) ◽  
pp. 103-114 ◽  
Author(s):  
SCOTT BARBAY ◽  
ERIC K. PEDEN ◽  
GERALD FALCHOOK ◽  
RANDOLPH J. NUDO
Keyword(s):  
Sciatic Nerve ◽  
Somatosensory Cortex ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Cutaneous Stimulation ◽  
Stimulation Of

scholarly journals An Index of Topographic Normality in Rat Somatosensory Cortex: Application to a Sciatic Nerve Crush Model

2002 ◽  
Vol 88 (3) ◽  
pp. 1339-1351 ◽  
Author(s):  
Scott Barbay ◽  
Eric K. Peden ◽  
Gerald Falchook ◽  
Randolph J. Nudo
Keyword(s):  
Sciatic Nerve ◽  
Nerve Regeneration ◽  
Somatosensory Cortex ◽  
Functional Recovery ◽  
Peripheral Nerve Regeneration ◽  
Control Group ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Somatotopic Organization ◽  
Cortical Topography

Previous studies have demonstrated that peripheral denervation of the skin is reflected in the CNS as a reorganization of somatotopic representations. In cases in which peripheral nerve regeneration occurs there is a gradual reactivation of cortex by novel receptive fields that is reversed as regenerated nerves reestablish connections with the original skin surface. Functional recovery appears to depend on the pattern in which somatotopic organization in the cortex is reestablished. The relationship between functional recovery and cortical topography is not precise, however, since the descriptions of postinjury representations in the cortex have been largely descriptive and not quantitative. The purpose of this study was to derive an index to quantify deviations from normal somatotopic organization in the somatosensory cortex. Multiunit recordings of cutaneous representations in the somatosensory cortex (S1) of the rat were defined using Semmes-Weinstein monofilaments to stimulate the skin over the distal hindlimb of the rat 2 and 4 months after a sciatic nerve crush. To derive a sensitive index of topography, the sciatic nerve crush was selected as the injury model since nerve regeneration following crush injuries has been reported to reinstate preinjury cortical topography. Group comparisons were made with an intact control group. The results show that there were subtle, but significant differences in topography between rats with a regenerated sciatic nerve and normal rats. In addition, average thresholds for evoking cortical responses were higher than normal (but within normal range) 2 and 4 months after the crush. These results demonstrate that the index of topography derived for this study can reveal deviations that may not be distinguishable from normal topography when based on qualitative descriptions.

Muscle-derived GDNF facilitates motor nerve recovery following sciatic nerve crush injury

2007 ◽  
Vol 205 (3) ◽  
pp. S92
Author(s):  
Terence M. Myckatyn ◽  
Christina Kenney ◽  
Alice Tong ◽  
Jessica Duan ◽  
Daniel Hunter ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Motor Nerve ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Nerve Recovery ◽  
Nerve Crush Injury

Functional Recovery and Vitamin E Level Following Sciatic Nerve Crush Injury in Normal and Diabetic Rats

1998 ◽  
Vol 96 (3-4) ◽  
pp. 245-254 ◽  
Author(s):  
Khalaf Al Moutaery ◽  
Mohammed Arshaduddin ◽  
Mohammad Tariq ◽  
Saleh Al Deeb
Keyword(s):  
Vitamin E ◽  
Sciatic Nerve ◽  
Functional Recovery ◽  
Diabetic Rats ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Nerve Crush Injury

scholarly journals Canine Adipose-Derived Mesenchymal Stromal Cells Enhance Neuroregeneration in a Rat Model of Sciatic Nerve Crush Injury

2018 ◽  
Vol 28 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Diego Noé Rodríguez Sánchez ◽  
Luiz Antonio de Lima Resende ◽  
Giovana Boff Araujo Pinto ◽  
Ana Lívia de Carvalho Bovolato ◽  
Fábio Sossai Possebon ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Mesenchymal Stromal Cells ◽  
Rat Model ◽  
Stromal Cells ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Muscle Weight ◽  
Nerve Crush ◽  
Nerve Crush Injury

Crush injuries in peripheral nerves are frequent and induce long-term disability with motor and sensory deficits. Due to axonal and myelin sheath disruptions, strategies for optimized axonal regeneration are needed. Multipotent mesenchymal stromal cells (MSC) are promising because of their anti-inflammatory properties and secretion of neurotrophins. The present study investigated the effect of canine adipose tissue MSC (Ad-MSC) transplantation in an experimental sciatic nerve crush injury. Wistar rats were divided into three groups: sham ( n = 8); Crush+PBS ( n = 8); Crush+MSC ( n = 8). Measurements of sciatic nerve functional index (SFI), muscle mass, and electromyography (EMG) were performed. Canine Ad-MSC showed mesodermal characteristics (CD34-, CD45-, CD44+, CD90+ and CD105+) and multipotentiality due to chondrogenic, adipogenic, and osteogenic differentiation. SFI during weeks 3 and 4 was significantly higher in the Crush+MSC group ( p < 0.001). During week 4, the EMG latency in the Crush+MSC groups had better near normality ( p < 0.05). The EMG amplitude showed results close to normality during week 4 in the Crush+MSC group ( p < 0.04). There were no statistical differences in muscle weight between the groups ( p > 0.05), but there was a tendency toward weight gain in the Crush+MSC groups. Better motor functional recovery after crush and perineural canine Ad-MSC transplantation was observed during week 2. This was maintained till week 4. In conclusion, the canine Ad-MSC transplantation showed early pro-regenerative effects between 2–4 weeks in the rat model of sciatic nerve crush injury.

Up-Regulation of NF45 Correlates with Schwann Cell Proliferation After Sciatic Nerve Crush

2015 ◽  
Vol 56 (1) ◽  
pp. 216-227 ◽  
Author(s):  
Youhua Wang ◽  
Shiran Zhou ◽  
Hua Xu ◽  
Shixian Yan ◽  
Dawei Xu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Sciatic Nerve ◽  
Schwann Cell ◽  
Sciatic Nerve Crush ◽  
Nerve Crush

scholarly journals Regeneration of sciatic nerve crush injury by a hydroxyapatite nanoparticle-containing collagen type I hydrogel

2017 ◽  
Vol 68 (5) ◽  
pp. 579-587 ◽  
Author(s):  
Majid Salehi ◽  
Mahdi Naseri-Nosar ◽  
Somayeh Ebrahimi-Barough ◽  
Mohammdreza Nourani ◽  
Ahmad Vaez ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Collagen Type ◽  
Collagen Type I ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Type I ◽  
Nerve Crush ◽  
Nerve Crush Injury
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