Multifractal analysis of wide dynamic range neuron discharge profiles in normal rats and in rats with sciatic nerve constriction

1999 ◽  
Vol 16 (2) ◽  
pp. 89-102 ◽  
Author(s):  
GABRIELE BIELLA ◽  
GIANFAUSTO SALVADORI ◽  
MARIA LUISA SOTGIU
Keyword(s):  
Sciatic Nerve ◽  
Multifractal Analysis ◽  
Dynamic Range ◽  
Wide Dynamic Range ◽  
Wide Dynamic Range Neuron

The effect of galanin on wide-dynamic range neuron activity in the spinal dorsal horn of rats

2001 ◽  
Vol 101 (1-3) ◽  
pp. 179-182 ◽  
Author(s):  
Long-Chuan Yu ◽  
Shi-Lian Xu ◽  
Wei Xiong ◽  
Thomas Lundeberg
Keyword(s):  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Dynamic Range ◽  
Neuron Activity ◽  
Wide Dynamic Range ◽  
Spinal Dorsal ◽  
Wide Dynamic Range Neuron

scholarly journals Acute pressure on the sciatic nerve results in rapid inhibition of the wide dynamic range neuronal response

2012 ◽  
Vol 13 (1) ◽  
pp. 147 ◽  
Author(s):  
Wenxue Wang ◽  
Wei Tan ◽  
Danping Luo ◽  
Jianhua Lin ◽  
Yaoqing Yu ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Dynamic Range ◽  
Neuronal Response ◽  
Wide Dynamic Range

Effect of Spinal Morphine after Long-term Potentiation of Wide Dynamic Range Neurones in the Rat

2000 ◽  
Vol 92 (1) ◽  
pp. 140-140 ◽  
Author(s):  
Lars Jørgen Rygh ◽  
Mark Green ◽  
Nuwan Athauda ◽  
Arne Tjølsen ◽  
Anthony H. Dickenson
Keyword(s):  
Sciatic Nerve ◽  
Dynamic Range ◽  
Long Term Potentiation ◽  
Evoked Responses ◽  
Wide Dynamic Range ◽  
Anesthetized Rats ◽  
Term Potentiation ◽  
C Fiber ◽  
Group 2

Background Studies have shown that long-term increase in the excitability of single wide dynamic range neurones in the spinal dorsal horn of rats may be induced after tetanic stimulation to the sciatic nerve. This sensory event is possibly an in vivo counterpart of long-term potentiation, described in the brain. This study investigated whether this phenomenon occurs in the halothane-anesthetized rat and whether the antinociceptive effects of spinally administered morphine are altered when tested on the enhanced activity. Methods Single unit extracellular recordings were made in three different groups of halothane-anesthetized rats (n = 6 in each group). In group 1, the evoked neuronal responses of wide dynamic range neurones by a single electrical stimulus to the peripheral nerve were recorded every 4 min, for 1 h before (baseline) and for 3 h after brief high-frequency conditioning stimulation of the sciatic nerve. In group 2, morphine was applied onto the spinal cord after long-term potentiation had been established. Increasing concentrations of morphine were added until the C fiber-evoked responses were abolished; this was followed by naloxone reversal. In group 3, the same protocol as in group 2 was used except a waiting period substituted for the electrical conditioning. Results The C fiber-evoked responses were significantly increased (P < 0.001) after conditioning compared with baseline and those in control animals. Further, significantly higher concentrations of morphine (P = 0.008) were needed to abolish the C fiber-evoked responses in tetanized animals than in control animals. Naloxone reversed the effects of morphine to the predrug potentiated baseline in group 2, showing that opioids do not block the maintenance of spinal long-term potentiation. Conclusions Long-term potentiation of C fiber-evoked responses also can be induced in halothane-anesthetized rats, and morphine seems to have less potency during such conditions. These data suggest that long-term potentiation-like mechanisms may underlie some forms of hyperalgesia associated with a reduced effect of morphine.

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