scholarly journals Modulation of the Colonic Bacterial Flora Affects Differently Bacterial Translocation and Liver Injury in an Acute Liver Injury Model

1999 ◽  
Vol 11 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Diya Adawi, Göran Molin, Siv Ahrné,
Keyword(s):  
Liver Injury ◽  
Bacterial Translocation ◽  
Acute Liver Injury ◽  
Bacterial Flora ◽  
Injury Model

Identification of the translocating bacteria in rats with acute liver injury and their relation to the bacterial flora of the intestinal mucosa

Apmis ◽  
2008 ◽  
Vol 109 (7-8) ◽  
pp. 551-558
Author(s):  
Mei Wang ◽  
Diya Adawi ◽  
Göran Molin ◽  
Bertil Pettersson ◽  
Bengt Jeppsson ◽  
...  
Keyword(s):  
Liver Injury ◽  
Intestinal Mucosa ◽  
Acute Liver Injury ◽  
Bacterial Flora

scholarly journals Hepatoprotective Effects of a Chinese Herbal Formula, Longyin Decoction, on Carbon-Tetrachloride-Induced Liver Injury in Chickens

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Chunguang Wang ◽  
Tie Zhang ◽  
Xuemei Cui ◽  
Shuang Li ◽  
Xinghua Zhao ◽  
...  
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
Pectoral Muscle ◽  
High Dose ◽  
Herbal Formula ◽  
Injury Model ◽  
Hepatoprotective Effects ◽  
Injury Models ◽  
Qualitative Determination ◽  
Different Doses

The objective of this study is to establish poultry liver injury model induced by (CCl4) and seek effective hepatoprotective herbals for clinical application. Different doses of CCl4dissolved in vegetable oil (1 : 1,V/V) were injected via pectoral muscle to induce acute liver injury model in chickens. An herbal formula, Longyin decoction, was prepared for hepatoprotection test on chicken acute liver injury models. The pathologic changes of the liver were observed, and the activities of ALT and AST were, respectively, detected to evaluate the hepatoprotective effects of Longyin decoction on chickens. The chicken acute liver injury model was successfully established by injecting CCl4via pectoral muscle. The best dose of CCl4inducing chicken liver injury was 4.0 mL/kg·BW (body weight). The results of qualitative determination by HPTLC showed that the components of Longyin decoction containedGentian, Capillaries, Gardenia,andBupleurum root. In the high-dose Longyin group and the middle-dose Longyin group, the pathological changes of the damaged liver were mitigated and the activities of ALT and AST in serum were reduced significantly. Longyin decoction has obvious hepatoprotective effect on acute liver injury induced by CCl4.

Salvianolic acid B exerts a protective effect in acute liver injury by regulating the Nrf2/HO-1 signaling pathway

2020 ◽  
Vol 98 (3) ◽  
pp. 162-168 ◽  
Author(s):  
Yong-mei Jin ◽  
Xiang-ming Tao ◽  
Yi-ning Shi ◽  
Youjin Lu ◽  
Jin-yu Mei
Keyword(s):  
Liver Injury ◽  
Signaling Pathway ◽  
Acute Liver Injury ◽  
Damage Model ◽  
Underlying Mechanism ◽  
Salvianolic Acid B ◽  
Salvianolic Acid ◽  
Injury Model

Salvianolic acid B (Sal B) exerts strong antioxidant activity and eliminates the free radical effect. However, how it affects the antioxidant pathway is not very clear. The objective of this study was to investigate the underlying mechanism of Sal B in CCl4-induced acute liver injury, especially its effect on the Nrf2/HO-1 signaling pathway. For the in vivo experiment, an acute liver injury model was induced using CCl4 and treated with Sal B. For the in vitro experiment, an oxidative damage model was established followed by Sal B treatment. Serum biochemical indicators and reactive oxygen species activity were detected using corresponding kits. Oxidant/antioxidant status was determined based on the levels of malondialdehyde, glutathione, and superoxide dismutase. Nrf2 and HO-1 levels were analyzed by Western blotting and immunohistochemical staining. Sal B treatment improved liver histology, decreased the aminotransferase levels, and attenuated oxidative stress in the acute liver injury model. Nrf2 and HO-1 levels were increased both in vivo and in vitro. Sal B suppresses acute liver injury and Nrf2/HO-1 signaling plays a key role in this process.

FOXA2 overexpressed adipose derived stem cells attenuated acute liver injury model

2017 ◽  
Vol 66 (1) ◽  
pp. S656-S657
Author(s):  
Y.J. Chae ◽  
D.W. Jun ◽  
S.B. Ahn ◽  
W.K. Saeed ◽  
J.S. Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Adipose Derived Stem Cells ◽  
Injury Model

Dynamics of bacterial translocation in acute liver injury induced by D-galactosamine in rat

Apmis ◽  
1996 ◽  
Vol 104 (1-6) ◽  
pp. 135-140 ◽  
Author(s):  
F. BEHZAD KASRAVI ◽  
DIYA ADAWI ◽  
GÖRAN MOLIN ◽  
STIG BENGMARK ◽  
BENGT JEPPSSON
Keyword(s):  
Liver Injury ◽  
Bacterial Translocation ◽  
Acute Liver Injury

scholarly journals A novel fluorescent probe for the detection of peroxynitrite and its application in acute liver injury model

Redox Biology ◽  
2021 ◽  
pp. 102068
Author(s):  
Chen Jin ◽  
Pengfei Wu ◽  
Yushun Yang ◽  
Zhenxiang He ◽  
Hailiang Zhu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Fluorescent Probe ◽  
Acute Liver Injury ◽  
Injury Model
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