Effect of short-term antenatal dexamethasone administration on type I collagen synthesis and degradation in preterm infants at birth

2001 ◽  
Vol 90 (8) ◽  
pp. 921-925
Author(s):  
T Saarela, J Risteli, A Kauppila, Mai
Keyword(s):  
Preterm Infants ◽  
Collagen Synthesis ◽  
Type I Collagen ◽  
Type I ◽  
Short Term ◽  
Synthesis And Degradation

Serum Markers of Type I Collagen Synthesis and Degradation in Amyotrophic Lateral Sclerosis

2000 ◽  
Vol 44 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Seiitsu Ono ◽  
Takashi Imai ◽  
Natsue Shimizu ◽  
Megumi Nakayama ◽  
Takahiko Yamano ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Collagen Synthesis ◽  
Type I Collagen ◽  
Serum Markers ◽  
Type I ◽  
Lateral Sclerosis ◽  
Synthesis And Degradation

Short-term immobilization and recovery affect skeletal muscle but not collagen tissue turnover in humans

2008 ◽  
Vol 105 (6) ◽  
pp. 1845-1851 ◽  
Author(s):  
Britt Christensen ◽  
Eva Dyrberg ◽  
Per Aagaard ◽  
Michael Kjaer ◽  
Henning Langberg
Keyword(s):  
Collagen Synthesis ◽  
Type I Collagen ◽  
Recovery Period ◽  
Triceps Surae ◽  
Muscle Size ◽  
Type I ◽  
Short Term ◽  
Cross Sectional ◽  
Significant Difference ◽  
Triceps Surae Muscles

Not much is known about the effects of immobilization and subsequent recovery on tendon connective tissue. In the present study, healthy young men had their nondominant leg immobilized for a 2-wk period, followed by a recovery period of the same length. Immobilization resulted in a mean decrease of 6% (5,413 to 5,077 mm2) in cross-sectional area (CSA) of the triceps surae muscles and a mean decrease of 9% (261 to 238 N·m) in strength of the immobilized calf muscles. Two weeks of recovery resulted in a 6% increased in CSA (to 5,367 mm2), whereas strength remained suppressed (240 N·m). No difference in Achilles tendon CSA was detected between the two legs at any time point. Local tendon collagen synthesis, measured as the peritendinous concentrations of PINP (NH2-terminal propeptide of type I collagen; indirect marker for collagen synthesis), was unchanged after 2 wk of immobilization. However, peritendinous levels of PINP were significantly elevated in the immobilized leg (15 to 139 ng/ml) following 2 wk of remobilization compared with preimmobilization levels. In contradiction hereto, systemic concentrations of PINP remained unchanged throughout the study. Immobilization reduced muscle size and strength, while tendon size and collagen turnover were unchanged. While recovery resulted in an increase in muscle size, strength was unchanged. No significant difference in tendon size could be detected between the two legs after 2 wk of recovery, although collagen synthesis was increased in the previously immobilized leg. Thus 2 wk of immobilization are sufficient to induce significant changes in muscle tissue, whereas tendon tissue seems to be more resistant to short-term immobilization.

Effects of long-term immobilization and recovery on human triceps surae and collagen turnover in the Achilles tendon in patients with healing ankle fracture

2008 ◽  
Vol 105 (2) ◽  
pp. 420-426 ◽  
Author(s):  
Britt Christensen ◽  
Eva Dyrberg ◽  
Per Aagaard ◽  
Susanne Enehjelm ◽  
Michael Krogsgaard ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Achilles Tendon ◽  
Ankle Fracture ◽  
Collagen Synthesis ◽  
Type I Collagen ◽  
Calf Muscle ◽  
Triceps Surae ◽  
Type I ◽  
Collagen Turnover ◽  
Synthesis And Degradation

The aim of the present study was to analyze how human tendon connective tissue responds to an ∼7-wk period of immobilization and a remobilization period of a similar length, in patients with unilateral ankle fracture, which is currently unknown. Calf muscle cross-sectional area (CSA) decreased by 15% (5,316 to 4,517 mm2) and strength by 54% (239 to 110 N·m) in the immobilized leg after 7 wk. During the 7-wk remobilization, the CSA increased by 9% (to 4,943 mm2) and strength by 37% (to 176 Nm). Achilles tendon CSA did not change significantly during either immobilization or remobilization. Local collagen turnover was measured as the peritendinous concentrations of NH2-terminal propeptide of type I collagen (PINP) and COOH-terminal telopeptide region of type I collagen (ICTP), markers thought to be indexes of type I collagen synthesis and degradation, respectively. Both markers were increased (PINP: 257 vs. 56 ng/ml; ICTP: 9.8 vs. 2.1 μg/l) in the immobilized leg compared with the control leg after the 7 wk of immobilization, and levels decreased again in the immobilized leg during the recovery period (PINP: 103 vs. 44 ng/ml; ICTP: 4.2 vs. 1.9 μg/l). A significant reduction in calf muscle CSA and strength was found in relation to 7 wk of immobilization. Immobilization increased both collagen synthesis and degradation in tendon near tissue. However, it cannot be excluded that the facture of the ankle in close proximity could have affected these data. Remobilization increased muscle size and strength and tendon synthesis and degradation decreased to baseline levels. These dynamic changes in tendon connective tissue turnover were not associated with macroscopic changes in tendon size.

scholarly journals Type I collagen synthesis and degradation in peritendinous tissue after exercise determined by microdialysis in humans

1999 ◽  
Vol 521 (1) ◽  
pp. 299-306 ◽  
Author(s):  
Henning Langberg ◽  
Dorthe Skovgaard ◽  
Lars J. Petersen ◽  
Jens Bülow ◽  
Michael Kjaer
Keyword(s):  
Collagen Synthesis ◽  
Type I Collagen ◽  
Type I ◽  
Synthesis And Degradation
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