Concurrent Cisplatin-Based Chemoradiation for Cervical Carcinoma: Tumor Response, Toxicity, and Serum Cytokine Profiles

2006 ◽  
Vol 24 (4) ◽  
pp. 390-395 ◽  
Author(s):  
Yuh-Cheng Yang ◽  
Kung-Liahng Wang ◽  
Tsung-Hsien Su ◽  
Hui-Fen Liao ◽  
Meng-Hao Wu ◽  
...  
Keyword(s):  
Cervical Carcinoma ◽  
Tumor Response ◽  
Serum Cytokine ◽  
Cytokine Profiles ◽  
Carcinoma Tumor

scholarly journals Reactive arthritis and undifferentiated peripheral spondyloarthritis share human leucocyte antigen B27 subtypes and serum and synovial fluid cytokine profiles

Rheumatology ◽  
2020 ◽  
Author(s):  
Jyoti Ranjan Parida ◽  
Sandeep Kumar ◽  
Sakir Ahmed ◽  
Smriti Chaurasia ◽  
Ratnadeep Mukherjee ◽  
...  
Keyword(s):  
Statistical Difference ◽  
Human Leucocyte Antigen ◽  
Healthy Controls ◽  
Hla B27 ◽  
Serum Cytokine ◽  
Cytokine Profiles ◽  
Cytokine Levels ◽  
Peripheral Spondyloarthritis ◽  
Multiplex Cytokine ◽  
Age And Sex

Abstract Objectives Peripheral SpA (pSpA) is comprised of ReA, PsA, enteritis-associated arthritis and undifferentiated pSpA (upSpA). ReA and upSpA share T cell oligotypes and metabolomics in serum and SF. We investigated HLA-B27 subtypes and cytokines in serum and SF that were compared between ReA and upSpA. Methods ReA and upSpA were compared in two cohorts. In cohort I (44 ReA and 56 upSpA), HLA-B27 subtyping was carried out. In cohort II (17 ReA and 21 upSpA), serum and SF cytokines were compared using a multiplex cytokine bead assay (27 cytokines). A total of 28 healthy controls with similar age and sex to cohort II were included for comparison of serum cytokine levels. Results In cohort I, HLA-B27 was positive in 81.8% (36/44) of ReA and 85.71% (48/56) of upSpA patients. HLA-B27 typing was successful in 70 patients (30 ReA and 40 uSpA). HLA-B*2705 was the most common, followed by HLA-B*2704 and HLA-B*2707. Frequencies were the same between ReA and upSpA. In cohort II, 14 cytokines were detectable in the serum of patients. The levels of eight cytokines were higher than in the controls. The cytokine levels of ReA and upSpA were similar. Sixteen cytokines were detectable in the SF of patients. There was no statistical difference in the levels between ReA and upSpA. The cytokine profiles in sera and SF were also similar among HLA-B27-positive and negative patients. Conclusion ReA and upSpA have similar HLA-B27 subtype associations and similar cytokine profiles. They should be considered as a single entity during studies as well as clinical management.

Y-003. Longitudinal serum cytokine profiles in gestational hypertension and preeclampsia

2021 ◽  
Vol 25 ◽  
pp. e18
Author(s):  
Anders H. Jarmund ◽  
Guro F. Giskeødegård ◽  
Johanne J. Rakner ◽  
Live M. T. Stokkeland ◽  
Mariell Ryssdal ◽  
...  
Keyword(s):  
Gestational Hypertension ◽  
Serum Cytokine ◽  
Cytokine Profiles

scholarly journals Serum cytokine profiles associated with early allograft dysfunction in patients undergoing liver transplantation

2012 ◽  
Vol 18 (2) ◽  
pp. 166-176 ◽  
Author(s):  
Benjamin H. Friedman ◽  
Joshua H. Wolf ◽  
Liqing Wang ◽  
Mary E. Putt ◽  
Abraham Shaked ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Serum Cytokine ◽  
Allograft Dysfunction ◽  
Cytokine Profiles ◽  
Early Allograft Dysfunction

scholarly journals Influence of Vitamin D3 Supplementation on Infliximab Effectiveness in Chinese Patients With Crohn's Disease: A Retrospective Cohort Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Sheng-long Xia ◽  
Quan-jia Min ◽  
Xiao-xiao Shao ◽  
Dao-po Lin ◽  
Guo-long Ma ◽  
...  
Keyword(s):  
Cohort Study ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin D3 ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Remission Rate ◽  
Serum Cytokine ◽  
Cytokine Profiles ◽  
Tnf Α

Background: It remains uncertain whether vitamin D3 (vitD3) supplementation is beneficial for remission of Crohn's disease (CD). The influence of vitD3 supplementation on Infliximab (IFX) effectiveness was analyzed in Chinese CD patients.Methods: In this retrospective cohort study, moderate-to-severe CD patients, who were bio-naïve and prescribed with IFX treatment for at least 54 weeks, were recorded from January 2014 to December 2019. VitD3 supplementation was defined as patients additionally took oral vitD3 (125 IU/d) within 3 days after the first infusion and persisted in the whole follow-up period. Disease activity was assessed using Harvey-Bradshaw Index (HBI). Serum cytokine profiles (IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ) were quantitatively analyzed in a subset of all patients at baseline and 54-week after intervention.Results: Among 73 enrolled patients, 37 took vitD3 regularly (D3-patients), the others (non-D3-patients) did not. At 54-week, the mean 25-hydroxyvitaminD level increased in D3-patients (20.33 vs. 15.07 ng/mL, P < 0.001). The clinical remission rate was higher in D3-patients compared to non-D3-patients (83.8 vs. 61.6%, P = 0.030). The decrease of HBI from baseline to 54-week was more in D3-patients than non-D3-patients (7.41 ± 3.0 vs. 6.28 ± 2.75, P = 0.023). Furthermore, vitD3 supplementation was independently related to the increase of remission rate at 54-week in D3-patients (β = −1.667, P = 0.015). The benefit of vitD3 supplementation was significant only in patients with deficient vitD3 (all P < 0.05), but not in non-deficient vitD3. A total of nine patients (four non-D3-patients and five D3-patients) were selected to determine serum cytokine profiles after 54-week IFX treatment. In non-D3-patients, the decreases of TNF-α and IL-6 at 54-week were more obvious than at baseline (P = 0.032, 0.022, respectively). In D3-patients, however, only IL-10 increased at 54-week compared with its baseline value (P = 0.037).Conclusions: VitD3 supplementation could improve IFX effectiveness in CD patients, especially for patients with vitD3 deficiency. This beneficial effect of vitD3 supplementation probably arose from the up-regulation of IL-10.Trial Registration: NCT04606017.

scholarly journals Higher serum vitamin D levels are associated with protective serum cytokine profiles in patients with ulcerative colitis

Cytokine ◽  
2018 ◽  
Vol 103 ◽  
pp. 38-45 ◽  
Author(s):  
John Gubatan ◽  
Shuji Mitsuhashi ◽  
Maria Serena Longhi ◽  
Talia Zenlea ◽  
Laura Rosenberg ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Serum Cytokine ◽  
Serum Vitamin D ◽  
Cytokine Profiles ◽  
Vitamin D Levels

scholarly journals Serum cytokine profiles and Mac-2 binding protein glycosylation isomer (M2BPGi) level in patients with autoimmune hepatitis

Medicine ◽  
2018 ◽  
Vol 97 (50) ◽  
pp. e13450 ◽  
Author(s):  
Kiyoshi Migita ◽  
Yoshiro Horai ◽  
Hideko Kozuru ◽  
Tomohiro Koga ◽  
Seigo Abiru ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Binding Protein ◽  
Protein Glycosylation ◽  
Serum Cytokine ◽  
Cytokine Profiles

scholarly journals Serum Cytokine Profiles Associated with Specific Adjuvants Used in a DNA Prime-Protein Boost Vaccination Strategy

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e74820 ◽  
Author(s):  
Rachel Buglione-Corbett ◽  
Kimberly Pouliot ◽  
Robyn Marty-Roix ◽  
Kim West ◽  
Shixia Wang ◽  
...  
Keyword(s):  
Vaccination Strategy ◽  
Serum Cytokine ◽  
Cytokine Profiles ◽  
Boost Vaccination ◽  
Protein Boost
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