SYSTEMIC INDICATORS OF INORGANIC ARSENIC TOXICITY IN FOUR ANIMAL SPECIES

2000 ◽  
Vol 59 (2) ◽  
pp. 119-134 ◽  
Author(s):  
Roger D. Mitchell, Felix Ayala-Fier
Keyword(s):  
Animal Species ◽  
Inorganic Arsenic ◽  
Arsenic Toxicity ◽  
Systemic Indicators

Influence of thyroxine and n-propylthiouracil on nephro-toxicity of inorganic arsenic in rat

2006 ◽  
Vol 22 (3) ◽  
pp. 137-145 ◽  
Author(s):  
SVS Rana ◽  
Tanu Allen
Keyword(s):  
Arsenic Trioxide ◽  
Adaptive Response ◽  
Renal Toxicity ◽  
Inorganic Arsenic ◽  
Renal Tissue ◽  
Arsenic Toxicity ◽  
Glutathione S Transferase ◽  
Ultrastructural Studies ◽  
Pre Treatment ◽  
Arsenic Excretion

The effect of hyper or hypoactive thyroid on the renal toxicity of arsenic trioxide has been studied in rats. It was observed that pre-treatment of rats with thyroxine stimulates arsenic excretion in urine. The anti-thyroid drug n-propylthiouracil (PTU), inhibits the accumulation of arsenic in renal tissue. Both treatments affect the renal pathology. Histopathological lesions are less severe in PTU and arsenic-treated rats in comparison to thyroxine and arsenic-treated rats. Ultrastructural studies support light microscopical observations. An adaptive response was noticed against arsenic in PTU pre-treated rats. We attribute this response to decreased glutathione-S-transferase (GSH) activity and increased GSH synthesis in the kidney. A relationship between thyroidal activity and arsenic toxicity is suggested by present observations.

scholarly journals ARSENIC: A HARMFUL AND DESECRATE COMPOUND FOR THE HUMANS

2019 ◽  
pp. 24-29 ◽  
Author(s):  
SURESH CHANDRA ◽  
ARYENDU KUMAR SAINI ◽  
AKASH KUMAR GUPTA
Keyword(s):  
Drinking Water ◽  
Health Problem ◽  
Memory Function ◽  
Public Health Problem ◽  
Inorganic Arsenic ◽  
Major Public Health Problem ◽  
Arsenic Toxicity ◽  
High Concentration ◽  
Drinking Water Contamination ◽  
The World

Arsenic toxicity has become a burgeoning concern as several millions of people are exposed to this chemical through drinking water contamination by arsenic remains a major public health problem. Acute and chronic arsenic exposure through drinking water has been reported in many countries of the world, where a large proportion of drinking water is contaminated with high concentrations of arsenic. As contamination in groundwater has been found in more than 105 countries around the world, it has become the worldwide health problem as several millions of people are exposed to this toxicant. Arsenic contamination of different countries includes Bangladesh, India, Vietnam, Nepal, Thailand, and Chili is the major affected countries where inorganic arsenic in the groundwater with high concentration is seen. Arsenic is one of the most toxic metals which is originated from the natural environment. The catastrophe is that the majority of human arsenic toxicity is from polluted drinking water rather than agricultural sources (fertilizers or pesticides). The different areas across the Gangetic plains in Nepal and India also recently reported being affected by the arsenic. The hippocampus is a part of the limbic system that is crucial to memory function and spatial navigation. Hippocampus lesions in humans produce devastating impairments in declarative memory, and similar results have been seen in non-human primates with hippocampus neurobehavioral disorders.

Protective role of Saccharomyces cerevisiae on inorganic arsenic toxicity upon the intestinal epithelium

2017 ◽  
Vol 280 ◽  
pp. S179
Author(s):  
Gabriela Matuoka Chiocchetti ◽  
Sergi Puig Todolí ◽  
Dinoraz Vélez Pacios ◽  
Vicenta Devesa Péreza
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Intestinal Epithelium ◽  
Inorganic Arsenic ◽  
Protective Role ◽  
Arsenic Toxicity

scholarly journals In Vitro Evaluation of the Protective Role of Lactobacillus StrainsAgainst Inorganic Arsenic Toxicity

2020 ◽  
Vol 12 (4) ◽  
pp. 1484-1491 ◽  
Author(s):  
Gabriela de Matuoka e Chiocchetti ◽  
Vicente Monedero ◽  
Manuel Zúñiga ◽  
Dinoraz Vélez ◽  
Vicenta Devesa
Keyword(s):  
Inorganic Arsenic ◽  
Protective Role ◽  
Arsenic Toxicity ◽  
In Vitro Evaluation

scholarly journals Arsenic toxicity to cladocerans isolated and associated with iron: implications for aquatic environments

2016 ◽  
Vol 88 (suppl 1) ◽  
pp. 539-548 ◽  
Author(s):  
SUELLEN C.M. SALES ◽  
ARNOLA C. RIETZLER ◽  
MARCELA M. RIBEIRO
Keyword(s):  
Inorganic Arsenic ◽  
Mean Value ◽  
Effective Concentration ◽  
Aquatic Environments ◽  
Arsenic Toxicity ◽  
High Toxicity ◽  
Arsenic Metabolism ◽  
Mean Values ◽  
Daphnia Similis ◽  
Physical And Chemical

ABSTRACT Arsenic is an ametal ubiquitous in nature and known by its high toxicity. Many studies have tried to elucidate the arsenic metabolism in the cell and its impact to plants, animals and human health. In aqueous phase, inorganic arsenic is more common and its oxidation state (As III and As V) depends on physical and chemical environmental conditions. The aim of this study was to evaluate toxicity of arsenic to Daphnia similis and Ceriodaphnia silvestrii, isolated and associated with iron. The results showed differences in toxicity of As III and As V to both species. Effective concentration (EC50) mean values were 0.45 mg L-1 (As III) and 0.54 mg L-1 (As V) for D. similis, and 0.44 mg L-1 (As III) and 0.69 mg L-1 (As V) for C. silvestrii. However, As V IC25 mean value was 0.59 mg L-1, indicating that C. silvestrii has mechanisms to reduce arsenic toxicity. On the other hand, when associated with iron at 0.02 and 2.00 mg L-1, EC50 values decreased for D. similis (0.34 and 0.38 mg L-1) as well as C. silvestrii (0.37 and 0.37 mg L-1), showing synergistic effect of these substances.

Mode of action for inorganic arsenic toxicity and carcinogenesis

2014 ◽  
Vol 59 (11) ◽  
pp. 1078-1082 ◽  
Author(s):  
Puttappa R. Dodmane ◽  
Lora L. Arnold ◽  
Samuel M. Cohen
Keyword(s):  
Mode Of Action ◽  
Inorganic Arsenic ◽  
Arsenic Toxicity

scholarly journals Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity

2020 ◽  
Author(s):  
Francisco Inesta-Vaquera ◽  
Panida Navasumrit ◽  
Colin J. Henderson ◽  
Tanya G. Frangova ◽  
Tadashi Honda ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inorganic Arsenic ◽  
Cell Types ◽  
Epidemiological Studies ◽  
Arsenic Toxicity ◽  
Cardiovascular Failure ◽  
Naturally Occurring ◽  
Reporter Mice ◽  
Activation Of Transcription

AbstractInorganic arsenic (iAs) is a naturally occurring metalloid present in drinking water and polluted air exposing millions of people globally. Epidemiological studies have linked iAs exposure to the development of numerous diseases including cognitive impairment, cardiovascular failure and cancer. Despite intense research, an effective therapy for chronic arsenicosis has yet to be developed. Laboratory studies have been of great benefit in establishing the pathways involved in iAs toxicity and providing insights into its mechanism of action. However, the in vivo analysis of arsenic toxicity mechanisms has been difficult by the lack of reliable in vivo biomarkers of the effects of iAs. To resolve this issue we have applied the use of our recently developed stress reporter models to study iAs toxicity. The reporter mice Hmox1 (oxidative stress/inflammation; HOTT) and p21 (DNA damage) were exposed to iAs at acute and chronic, environmentally relevant, doses. We observed induction of the oxidative stress reporters in several cell types and tissues, which was largely dependent on the activation of transcription factor NRF2. We propose that our HOTT reporter model can be used as a surrogate biomarker of iAs-induced oxidative stress, and it constitutes a first-inclass platform to develop treatments in arsenicosis. Indeed, in a proof of concept experiment, the HOTT reporter mice were able to predict the therapeutic utility of the antioxidant N-acetyl cysteine in the prevention of iAs associated toxicity.

Total and Inorganic Arsenic in Freshwater Fish and Prawn in Thailand

2012 ◽  
Vol 75 (10) ◽  
pp. 1890-1895 ◽  
Author(s):  
PIYAWAT SAIPAN ◽  
SUTHEP RUANGWISES ◽  
BUNDIT TENGJAROENKUL ◽  
NONGLUCK RUANGWISES
Keyword(s):  
Animal Species ◽  
Macrobrachium Rosenbergii ◽  
Inorganic Arsenic ◽  
Weight Basis ◽  
Distribution Centers ◽  
Anabas Testudineus ◽  
Regulatory Standard ◽  
Wet Weight ◽  
Freshwater Animal ◽  
Channa Striata

Total and inorganic arsenic levels were determined in 120 samples of eight freshwater animal species collected from five distribution centers in the central region of Thailand between January and March 2011. Eight species with the highest annual catch, consisting of seven fish species and one prawn species, were analyzed. Concentrations of inorganic arsenic (on a wet weight basis) ranged from 0.010 μg/g in giant prawn (Macrobrachium rosenbergii) to 0.230 μg/g in striped snakehead (Channa striata). Climbing perch (Anabas testudineus) exhibited the highest mean concentrations of total arsenic (0.459 ± 0.137 μg/g), inorganic arsenic (0.121 ± 0.044 μg/g), and percentage of inorganic arsenic (26.2%). Inorganic arsenic levels found in freshwater animals in this study were much lower than the Thai regulatory standard of 2 μg/g.

scholarly journals Curcumin sensitizes Epstein‑Barr‑immortalized lymphoblastoid cell lines to inorganic arsenic toxicity

2021 ◽  
Vol 22 (2) ◽  
Author(s):  
Macario Martínez‑Castillo ◽  
Gabriela Cruz‑Robledo ◽  
Araceli Hernández‑Zavala ◽  
Emilio Córdova
Keyword(s):  
Cell Lines ◽  
Inorganic Arsenic ◽  
Lymphoblastoid Cell Lines ◽  
Arsenic Toxicity ◽  
Epstein Barr

scholarly journals Inorganic arsenic toxicity and alleviation strategies in rice

2021 ◽  
Vol 408 ◽  
pp. 124751
Author(s):  
Amos Musyoki Mawia ◽  
Suozhen Hui ◽  
Liang Zhou ◽  
Huijuan Li ◽  
Javaria Tabassum ◽  
...  
Keyword(s):  
Inorganic Arsenic ◽  
Arsenic Toxicity
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