Synthesis and Equilibrium Studies of the Metal Complexes of Heterocyclic Azo Compounds

1996 ◽  
Vol 26 (3) ◽  
pp. 493-507
Author(s):  
Mohamed M. Shoukry ◽  
Afkar K. Abdel Hadi ◽  
Afaf A. Razik ◽  
Shahira M. Shouheib
Keyword(s):  
Metal Complexes ◽  
Azo Compounds ◽  
Equilibrium Studies

Metal complexes of cephradine: Synthesis and equilibrium studies

1995 ◽  
Vol 126 (8-9) ◽  
pp. 909-918 ◽  
Author(s):  
M. M. Shoukry ◽  
E. M. Shoukry ◽  
S. M. El-Medani
Keyword(s):  
Metal Complexes ◽  
Equilibrium Studies

scholarly journals Synthesis, spectral characterization and biological activities of Ag(I), Pt(IV) and Au(III) complexes with novel azo dye ligand (N,N,O) derived from 2-amino-6-methoxy benzothiazole

2022 ◽  
Author(s):  
Hussein A. K. Kyhoiesh ◽  
Khalid J. Al-Adilee
Keyword(s):  
Crystal Structure ◽  
Endometrial Cancer ◽  
Nitrogen Atom ◽  
Metal Complexes ◽  
Cancer Cells ◽  
Azo Dye ◽  
Biological Activities ◽  
Antifungal Drugs ◽  
Azo Compounds ◽  
Spectroscopic Techniques

Abstract The novel ligand 2-[2'-(6-methoxybenzothiazolyl)azo]-3,5-dimethyl benzoic acid (6-MBTAMB), derived from 2-amino-6-methoxy benzothiazole, has been used to synthesize a series of new metal complexes of Ag(I), Pt(IV) and Au(III). The metal complexes were characterized by elemental analyses (CHNS), molar conductivity, crystal structure (XRD), spectroscopic techniques: FT-IR, 1H NMR, 13C NMR, UV-Vis, mass spectra, thermal analysis (TG-DTA), FE-SEM and magnetic properties. Results confirmed that the azo dye ligand behaves a tridentate and coordinates to the metal ion via nitrogen atom of azomethine group of heterocyclic benzothiazole ring, nitrogen atom of the azo group which is the farthest of the benzothiazole molecule and carboxylic oxygen. Antimicrobial properties of all newly synthesized azo compounds are also demonstrated against bacterial pathogenic organisms and fungi. These complexes are more effective against bacteria and less effective against fungi compared to standard antibacterial drugs (Novobiocin) and antifungal drugs (Cycloheximide). By using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging test, it was discovered that the complexes had good antioxidant properties. In addition, the (6-MBTAMB) and metal complexes were docked with the crystal structure of FGF Receptor 2 (FGFR2) kinase domain harboring the pathogenic gain of function K659E mutation identified in endometrial cancer using the Molecular Operating Environment module (MOE). In vitro studies on human endometrial cancer cell lines (MFE-296) as well as healthy human umbilical vein endothelial cells (HUVEC) show uptake of the intact compounds by the cancer cells and increased activity against the cancer cells.

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