Evolution of the analytical quality of soil testing laboratories integrated in a sample exchange program

1994 ◽  
Vol 25 (7-8) ◽  
pp. 1007-1014 ◽  
Author(s):  
J. A. Quaggio ◽  
H. Cantarella ◽  
B. van Raij
Author(s):  
Л.М. МАЛУКА ◽  
Т.В. ТУМАНЕНКО

Повышению результативности СМК лабораторий предприятий пищевой промышленности способствует внедрение риск-ориентированного подхода как основы реализации принципа постоянного улучшения. Обобщен опыт работы в области управления рисками и возможностями испытательной лаборатории предприятия. Даны рекомендации по оценке рисков и действий в отношении их. The introduction of a risk-based approach as the basis for the implementation of the principle of continuous improvement contributes to an increase in the effectiveness of the QMS of laboratories in the food enterprises. The experience of work in the field of risk management and capabilities of the enterprise testing laboratory is summarized. Recommendations for assessing risks and actions in relation to them are given.


Author(s):  
Maria Cristina Dijmarescu

Destructive and non-destructive testing of materials present a rapid expansion given by the increase in market demand caused by the desire to obtain an increasingly better quality of products. The continuous increase in quality demands leads directly to the need to implement and modernize the techniques, methods, and equipment used for quality control. Consequently, the need for product testing services has a rapid growth. This paper presents the strength and weaknesses of implementing IT tools for the estimation of the measurement uncertainty in testing laboratories and the impact of these tools on the economic part


Author(s):  
Nitin K. Mandavgade ◽  
Santosh B. Jaju ◽  
Ramesh R. Lakhe

The performance and maintenance of testing laboratories is a prime issue. The quality of coal test results not only depends on performance of individual results but it also depends on the performance of various tests in the same laboratory. Machine interference is a significant problem in many manufacturing system and testing equipment. The variation of results for testing equipment may be due to various factors which need to calculate the uncertainty of measurement to show the accuracy of the machine. In case of coal testing laboratory, the plant layout and surrounding environment affects the performance of the system. The machine interference comes under variable causes which may affect the result. This chapter proposes a methodology for constructing system performance measures, finding out the various factors responsible for variations in result. The chapter deals with estimation of machine interference existence using variable control chart approach for coal testing equipment. The analysis of results for such machine interference will be useful and significant for system designers and practitioners.


Author(s):  
Mario Plebani ◽  
Laura Sciacovelli ◽  
Ada Aita ◽  
Michela Pelloso ◽  
Maria Laura Chiozza

AbstractThe definition, implementation and monitoring of valuable analytical quality specifications have played a fundamental role in improving the quality of laboratory services and reducing the rates of analytical errors. However, a body of evidence has been accumulated on the relevance of the extra-analytical phases, namely the pre-analytical steps, their vulnerability and impact on the overall quality of the laboratory information. The identification and establishment of valueable quality indicators (QIs) represents a promising strategy for collecting data on quality in the total testing process (TTP) and, particularly, for detecting any mistakes made in the individual steps of the pre-analytical phase, thus providing useful information for quality improvement projects. The consensus achieved on the developed list of harmonized QIs is a premise for the further step: the identification of achievable and realistic performance targets based on the knowledge of the state-of-the-art. Data collected by several clinical laboratories worldwide allow the classification of performances for available QIs into three levels: optimum, desirable and minimum, in agreement with the widely accepted proposal for analytical quality specifications.


Author(s):  
Liu-Jia Zhang ◽  
Jing-Bai Li ◽  
Chao-Liu ◽  
Fang-Liu ◽  
Jia-Min Zhang
Keyword(s):  

2008 ◽  
Vol 13 (10) ◽  
pp. 999-1006 ◽  
Author(s):  
Caroline Engeloch ◽  
Ulrich Schopfer ◽  
Ingo Muckenschnabel ◽  
Francois Le Goff ◽  
Hervé Mees ◽  
...  

The impact of storage conditions on compound stability and compound solubility has been debated intensely over the past 5 years. At Novartis, the authors decided to opt for a storage concept that can be considered controversial because they are using a DMSO/water (90/10) mixture as standard solvent. To assess the effect of water in DMSO stocks on compound stability, the authors monitored the purity of a subset of 1404 compounds from ongoing medicinal chemistry projects over several months. The study demonstrated that 85% of the compounds were stable in wet DMSO over a 2-year period at 4 °C. This result validates the storage concept developed at Novartis as a pragmatic approach that takes advantage of the benefits of DMSO/water mixtures while mediating the disadvantages. In addition, the authors describe how purity data collected over the course of the chemical validation of high-throughput screening actives are used to improve the analytical quality of the Novartis screening deck. ( Journal of Biomolecular Screening 2008:999-1006)


Author(s):  
James O. Westgard ◽  
Sten A. Westgard

AbstractThere is a need to assess the quality being achieved for laboratory examinations that are being utilized to support evidence-based clinical guidelines. Application of Six Sigma concepts and metrics can provide an objective assessment of the current analytical quality of different examination procedures.A “Sigma Proficiency Assessment Chart” can be constructed for data obtained from proficiency testing and external quality assessment surveys to evaluate the observed imprecision and bias of method subgroups and determine quality on the Sigma scale.Data for hemoglobin AAssessment of quality on the Sigma scale provides evidence of the analytical performance that is being achieved relative to requirements for intended use and should be useful for identifying and prioritizing improvements that are needed in the analytical quality of laboratory examinations. In spite of global and national standardization programs, bias is still a critical limitation of current HbA


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