scholarly journals Dietary exposure to chemicals within the process of risk assessment: possible applications to substances that may cause allergic reactions

2005 ◽  
Vol 64 (4) ◽  
pp. 418-425 ◽  
Author(s):  
D. Arcella ◽  
C. Le Donne ◽  
C. Leclercq
Keyword(s):  
Risk Assessment ◽  
Dietary Exposure ◽  
Assessment Process ◽  
Hazardous Substances ◽  
Health Concern ◽  
Food Allergies ◽  
Screening Methods ◽  
Worst Case ◽  
Combining Data

Exposure assessment is one of the key parts of the risk assessment process. This task is crucial when evaluating substances for which only intake of toxicologically-important amounts can lead to adverse health effects. Ideally, dietary exposure to hazardous substances can be assessed by combining data on concentration in all food products with data on their consumption. However, it is considered to be neither cost-effective nor necessary to collect detailed data for every substance, and a stepwise procedure is commonly used to focus resources on the most important issues. Screening methods, designed to look for ‘worst case’ situations, are first used to target chemicals that might be of health concern for the general population or for certain at-risk groups. The quality of the dietary exposure assessments not only depends on the quality of the data collected, but also on the integration tools used for initial screening or for the eventual more precise estimations. A particular challenge is the evaluation of food allergens and components causing other forms of intolerances, since no reliable data seem to be currently available on the type of exposure (amounts and duration) required to induce a food allergy. A different approach from that used for dietary exposure to other hazardous substances has to be adopted. However, the methodologies (such as those used to collect food consumption data) and databases (in particular, information about food labels) developed in such a context could be useful to investigate the exposure conditions leading to the development of food allergies.

scholarly journals An Adaptive, Situation-Based Risk Assessment and Security Enforcement Framework for the Maritime Sector

Sensors ◽  
2021 ◽  
Vol 22 (1) ◽  
pp. 238
Author(s):  
Christos Grigoriadis ◽  
Romain Laborde ◽  
Antonin Verdier ◽  
Panayiotis Kotzanikolaou
Keyword(s):  
Risk Assessment ◽  
Security Policy ◽  
Risk Mitigation ◽  
Assessment Process ◽  
Adaptive Security ◽  
Efficient Manner ◽  
Worst Case ◽  
Risk Assessment Process ◽  
Security Controls ◽  
Dynamic Risk

Maritime processes involve actors and systems that continuously change their underlying environment, location and threat exposure. Thus, risk mitigation requires a dynamic risk assessment process, coupled with an adaptive, event driven security enforcement mechanism, to efficiently deal with dynamically evolving risks in a cost efficient manner. In this paper, we propose an adaptive security framework that covers both situational risk assessment and situational driven security policy deployment. We extend MITIGATE, a maritime-specific risk assessment methodology, to capture situations in the risk assessment process and thus produce fine-grained and situation-specific, dynamic risk estimations. Then, we integrate DynSMAUG, a situation-driven security management system, to enforce adaptive security policies that dynamically implement security controls specific to each situation. To validate the proposed framework, we test it based on maritime cargo transfer service. We utilize various maritime specific and generic systems employed during cargo transfer, to produce dynamic risks for various situations. Our results show that the proposed framework can effectively assess dynamic risks per situation and automate the enforcement of adaptive security controls per situation. This is an important improvement in contrast to static and situation-agnostic risk assessment frameworks, where security controls always default to worst-case risks, with a consequent impact on the cost and the applicability of proper security controls.

Risk assessment of chronic dietary exposure to the conjugated mycotoxin deoxynivalenol-3-β-glucoside in the Dutch population

2015 ◽  
Vol 8 (5) ◽  
pp. 561-572 ◽  
Author(s):  
E.M. Janssen ◽  
R.C. Sprong ◽  
P.W. Wester ◽  
M. De Boevre ◽  
M.J.B. Mengelers
Keyword(s):  
Risk Assessment ◽  
Body Weight ◽  
The Netherlands ◽  
Food Consumption ◽  
Upper Bound ◽  
Chronic Exposure ◽  
Dietary Exposure ◽  
Food Products ◽  
Dutch Population ◽  
Worst Case

In this study, a risk assessment of dietary exposure to the conjugated mycotoxin deoxynivalenol-3-β-glucoside (DON-3G) in the Dutch population was conducted. Data on DON-3G levels in food products available in the Netherlands are scarce. Therefore, data on co-occurring levels of DON-3G and deoxynivalenol (DON), its parent compound, were used to estimate the DON-3G/DON ratio for several food product categories. This resulted in a DON-3G/DON ratio of 0.2 (90% confidence interval (CI): 0.04-0.9) in grains & grain-milling products, 0.3 (90% CI: 0.03-2.8) in grain-based products and 0.8 (90% CI: 0.4-1.8) in beer. These ratios were applied to the Dutch monitoring data of DON to estimate the DON-3G concentrations in food products available in the Netherlands. DON and DON-3G concentrations were combined with food consumption data of two Dutch National Food Consumption Surveys to assess chronic exposure in young children (2-6 years), children (7-16 years) and adults (17-69 years) using the Monte Carlo Risk Assessment program. The chronic exposure levels of DON, DON-3G and the sum of both compounds (DON+DON-3G) were compared to the tolerable daily intake (TDI) of 1 μg/kg body weight/day which is based on the most critical effect of DON, namely decreased body weight gain. The assumption was made that DON-3G is deconjugated and then fully absorbed as DON in the gastro-intestinal tract. Exposure (P97.5) of the population aged 7-16 years and 17-69 years to DON or DON-3G separately, did not exceed the TDI. However, exposure to upper bound levels of DON+DON-3G (i.e. worst-case scenario) in the same age categories (P97.5) exceeded the TDI with a maximum factor of 1.3. Exposure (P97.5) of the 2-6 year-olds to DON was close to the TDI. Within this group, exposure (P97.5) to upper bound levels of DON+DON-3G exceeded the TDI with not more than a factor 2.

ILSI Europe’s Food Allergy Task Force: From Defining the Hazard to Assessing the Risk from Food Allergens

2018 ◽  
Vol 101 (1) ◽  
pp. 91-95 ◽  
Author(s):  
René R W Crevel ◽  
Stefan Ronsmans ◽  
Cyril F M Marsaux ◽  
Diána Bánáti
Keyword(s):  
Risk Assessment ◽  
Food Allergy ◽  
Task Force ◽  
World Health ◽  
Health Concern ◽  
Food Allergies ◽  
Food Allergens ◽  
The European Union ◽  
Funded Project ◽  
The Impact

Abstract The International Life Sciences Institute (ILSI) Europe Food Allergy Task Force was founded in response to early public concerns about the growing impact of food allergies almost coincidentally with the publication of the 1995 Food and Agriculture Organization-World Health Organization Technical Consultation on Food Allergies. In line with ILSI principles aimed to foster collaboration between stakeholders to promote consensus on science-based approaches to food safety and nutrition, the task force has played a central role since then in the development of risk assessment for food allergens. This ranged from consideration of the criteria to be applied to identifying allergens of public health concern through methodologies to determine the relationship between dose and the proportion of allergic individuals reacting, as well as the nature of the observed responses. The task force also promoted the application of novel, probabilistic risk assessment methods to better delineate the impact of benchmarks, such as reference doses, and actively participated in major European food allergy projects, such as EUROPREVALL, the European Union (EU)-funded project “The prevalence, cost and basis of food allergy across Europe;” and iFAAM, “Integrated approaches to food allergen and allergy risk management,” also an EU-funded project. Over the years, the task force’s work has evolved as answers to initial questions raised further issues: Its current work program includes a review of analytical methods and how different ones can best be deployed given their strengths and limitations. Another activity, which has just commenced, aims to develop a framework for stakeholders to achieve consensus on acceptable risk.

scholarly journals Estimation of the dietary exposure of polycyclic aromatic hydrocarbons in Syria and their health risks assessment

2020 ◽  
Vol 9 (2) ◽  
pp. 332-345
Author(s):  
Hour Krajian
Keyword(s):  
Risk Assessment ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Health Risk ◽  
Health Risk Assessment ◽  
Aromatic Hydrocarbons ◽  
Dietary Exposure ◽  
Health Concern ◽  
Polycyclic Aromatic ◽  
Urban Rural ◽  
General Populations

In this work, the exposure of people, through their diet, to polycyclic aromatic hydrocarbons (PAHs) has been assessed for the urban, rural, and general populations in Syria. The food categories consumed have been divided into major groups, and the health risk assessment on dietary exposure of PAHs determined in each food category. For this purpose, two approaches were used: incremental lifetime cancer risk (ILCR) and margin of exposure approach (MOE). The results showed that each of the following food categories: oils and fats, meat and meat products, vegetables, and cereals dominantly contribute in the dietary exposure of PAHs. Also their MOE values are the lowest. Additionally, they have higher ILCR values. Therefore, these groups are a main risk source to health. On the other hand, the dietary exposure of PAHs in each of urban, rural and general populations was of low health concern, whereas their ILCR values reached to 10E-05 in total food categories, nevertheless it remains lower than serious risk level (ILCR>10E-04). This work is the first study that is dealing with dietary exposure of PAHs and their health risk assessment in Syria.

scholarly journals Development of a Digital Video-Based Occupational Risk Assessment Method

2021 ◽  
Vol 9 ◽  
Author(s):  
Nils Ove Beese ◽  
Francisca S. Rodriguez ◽  
Jan Spilski ◽  
Thomas Lachmann
Keyword(s):  
Risk Assessment ◽  
Risk Factor ◽  
Video Analysis ◽  
Video Recording ◽  
Assessment Method ◽  
Occupational Risk ◽  
Assessment Tools ◽  
Assessment Process ◽  
Hazardous Substances ◽  
Risk Assessment Process

The development and implementation of an observational video-based risk assessment is described. Occupational risk assessment is one of the most important yet also challenging tasks for employers. Most assessment tools to date use questionnaires, expert interviews, and similar tools. Video analysis is a promising tool for risk assessment, but it needs an objective basis. A video of a plastering worker was recorded using a 360° camera. The recording was then analyzed using the developed observational matrix concerning Work Characteristics, Work Activities as well as potential risks. Risk factors present during the video of the work included lifting, fall from ladder, hazardous substances as well as occasionally bad posture. The worker had no or just one risk factor present during most of the time of the video recording, while only 16 s with more than one risk factor present according to the observational matrix. The paper presents a promising practical method to assess occupational risks on a case-by-case basis. It can help with the risk assessment process in companies which is required by law in some industrialized countries. The matrix in combination with video analysis is a first step toward digital observational risk assessment. It can also be the basis of an automated risk assessment process.

scholarly journals Bioaccumulation assessment of nanomaterials using freshwater invertebrate species

2021 ◽  
Vol 33 (1) ◽  
Author(s):  
Sebastian Kuehr ◽  
Verena Kosfeld ◽  
Christian Schlechtriem
Keyword(s):  
Risk Assessment ◽  
Bioconcentration Factor ◽  
Assessment Process ◽  
Production Volume ◽  
Worst Case ◽  
Test Species ◽  
Suitable Test ◽  
Invertebrate Species ◽  
Freshwater Invertebrate ◽  
Test Organisms

Abstract Background The high production volume of engineered nanomaterials (ENMs) may lead to high pressure on the environment, and a scientific assessment of ENMs that bioaccumulate in organisms and biomagnify in the food web is necessary. Within the regulation of chemicals in several jurisdictions, such as the European regulation REACH, the bioconcentration factor is the standard endpoint. The bioconcentration factor is mostly determined by flow-through fish tests. However, nanomaterials tend to agglomerate, which may lead to sedimentation in aquatic environments. The bioavailability of the tested nanomaterials may be thus impaired for pelagic species, including fish, in comparison to benthic or filtrating species. Several risk assessment regulations allow the usage of data gained during tests using invertebrates and such data may allow a waiver of further tests using vertebrates. The aim of this study was to elucidate the potential of different freshwater invertebrate species to be used in laboratory bioaccumulation studies on ENMs and to give some guidance for the use of bioaccumulation endpoints derived from studies using aquatic invertebrate species in the risk assessment process for ENMs. Results The existing literature related to the testing of nanomaterial bioaccumulation with freshwater invertebrates was screened and reviewed to find suitable test species with regard to their ecology and physiology, as well as laboratory test systems allowing to investigate the bioavailability/bioaccumulation of nanomaterials with the respective species. Bivalvia, gastropoda, isopoda, amphipoda, and branchiopoda were reviewed and their suitability for bioaccumulation testing was assessed. Amphipods and bivalves represent worst-case scenarios and show clear advantages to be used as test organisms. However, only amphipods allow the examination of two clearly independent exposure pathways (water and diet). Conclusion Amphipods are suitable test organisms for bioaccumulation testing of ENMs. The results from amphipod bioconcentration and biomagnification tests can be included in a tiered assessment suggested at the end of this study allowing a clear grading of the tested nanomaterials as “bioaccumulative” or “non bioaccumulative.” Due to the worst-case scenario of the amphipod test, this approach may allow a waiver of further vertebrate tests.

scholarly journals A Proposed Methodology for a Risk Assessment-Based Liposome Development Process

Pharmaceutics ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1164
Author(s):  
Zsófia Németh ◽  
Edina Pallagi ◽  
Dorina Gabriella Dobó ◽  
Ildikó Csóka
Keyword(s):  
Risk Assessment ◽  
Pharmaceutical Research ◽  
Assessment Process ◽  
Liposomal Formulation ◽  
Preparation Technique ◽  
Preparation Methods ◽  
Key Characteristics ◽  
Product Profile ◽  
Potential Factors

The requirements of a liposomal formulation vary depending on the pharmaceutical indication, the target patient population, and the corresponding route of administration. Different preparation methods require various material attributes (MAs) (properties and characteristics of the components) and process parameters (PPs) (settings of the preparation method). The identification of the quality target product profile for a liposome-based formulation, the critical quality attributes of the liposomes, and the possible MAs and PPs that may influence the key characteristics of the vesicles facilitates pharmaceutical research. Researchers can systematise their knowledge by using the quality by design (QbD) approach. The potential factors that influence the quality of the product can be collected and studied through a risk assessment process. In this paper, the requirements of a liposome formulation prepared via the thin-film hydration preparation technique are presented; furthermore, the possible factors that have an impact on the quality of the final product and have to be considered and specified during the development of a liposomal formulation are herein identified and collected. The understanding and the application of these elements of QbD in the pharmaceutical developments help to influence the quality, the achievements, and the success of the formulated product.

scholarly journals Safety Management Plan through Offsite Risk Assessment during Tank Terminal Construction

2020 ◽  
Vol 42 (11) ◽  
pp. 548-557
Author(s):  
Eun Sung Baek ◽  
Kyoshik Park
Keyword(s):  
Risk Assessment ◽  
Safety Management ◽  
Quantitative Risk Assessment ◽  
Assessment Process ◽  
Case Scenario ◽  
Worst Case ◽  
Alternative Scenario ◽  
Worst Case Scenario ◽  
Port Area ◽  
Storage Facilities

Objectives : In order to conduct the quantitative risk assessment for hazardous chemical storage facilities at the tank terminal in the port area, the entire risk assessment process was performed in according to the guidances of the Korea Ministry of Environment.Methods : The risk of the facility was derived by the worst-case scenario, alternative scenario, and then evaluated by KORA program. The countermeasures of the risk were suggested by the concept of LOPA.Results and Discussion : Focusing on the worst case scenario and alternative scenario among the scenario having effet to offsite, risk can be reduced to satisfy regulation by applying measures of passive, active, and managerial.Conclusions : According to the result of risk assessment on benzene storage tank and tank lorry when port construction, the amount of storage inside the tank has a significant impact on the offsite. It is necessary to organize the risk of benzene, and comprehensive management of tank terminal storage facilities.

Hormesis: the new approach in risk assessment?

2002 ◽  
Vol 21 (7) ◽  
pp. 399-400 ◽  
Author(s):  
D C Christiani ◽  
W Zhou
Keyword(s):  
Risk Assessment ◽  
Dose Response ◽  
Statistical Power ◽  
Risk Model ◽  
Industrial Hygiene ◽  
Model Systems ◽  
Assessment Process ◽  
Health Concern ◽  
Point Selection ◽  
End Points

Hormesis is a dose–response phenomenon characterized by either a U-shaped or an inverted U-shaped dose response depending on the different end points measured. In a paper in this issue of the journal, Drs Jayjock and Lewis advocate for the application of hormesis in the field of industrial hygiene, and suggest the use of hormesis as a default assumption in the risk assessment process. However, there are many difficulties for the utilization of hormesis in the field of industrial hygiene. Indeed, it is impossible to test the hormesis hypothesis in many commonly employed experimental model systems for end points of public health concern, and the mechanism of low-dose stimulation of hormesis is not clear. Even if hormesis were proven biologically, its assessment is limited due to difficulties of study design, biological markers selection, statistical power considerations, model and end point selection, and risk model approaches.

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