scholarly journals Iron, copper and fetal development

2004 ◽  
Vol 63 (4) ◽  
pp. 553-562 ◽  
Author(s):  
Lorraine Gambling ◽  
Harry J. McArdle
Keyword(s):  
Fetal Development ◽  
Startle Response ◽  
Growth And Development ◽  
Developed Countries ◽  
Fe Deficiency ◽  
Short Term ◽  
Iron Copper ◽  
Clinical Consequences ◽  
The Uk

Pregnancy is a period of rapid growth and cell differentiation for both the mother and fetus. Consequently, it is a period when both are vulnerable to changes in dietary supply, especially of those nutrients that are marginal under normal circumstances. In developed countries this vulnerability applies mainly to micronutrients. Even now, Fe deficiency is a common disorder, especially in pregnancy. Similarly, Cu intake in the UK population is rarely above adequate levels, which is a matter of some concern, both in terms of public health and possible clinical consequences. In early studies it was shown that lambs born to mothers on Cu-deficient pastures develop ‘swayback,’ with neurological and muscular symptoms that cannot be reversed by postnatal supplementation. More recently, rat studies have shown that responses such as the ‘startle’ response are lost in offspring of Cu-deficient mothers. Data have shown that prenatal Fe deficiency results in increased postnatal blood pressure, even though the offspring have normal dietary Fe levels from birth. These observations emphasise the importance of Fe and Cu in growth and development. In the present review the importance of these metals and the consequences, both short term and long term, of deficiency will be discussed and some possible mechanisms whereby these effects may be generated will be considered.

Iron and copper, and their interactions during development

2008 ◽  
Vol 36 (6) ◽  
pp. 1258-1261 ◽  
Author(s):  
Lorraine Gambling ◽  
Henriette S. Andersen ◽  
Harry J. McArdle
Keyword(s):  
Iron Deficiency ◽  
Growth And Development ◽  
Intracellular Transport ◽  
Developed Countries ◽  
Dietary Iron ◽  
Nutrient Deficiencies ◽  
Nutrient Requirements ◽  
Short And Long Term ◽  
Pregnant State

During development, the fetus is entirely dependent on the mother for its nutrient requirements. Subsequently, it is a period when both are vulnerable to changes in dietary supply, especially of those nutrients that are marginal under normal circumstances. In developed countries, this applies mainly to micronutrients. Even now, iron deficiency is a common disorder, especially in pregnancy. Similarly, copper intake in the U.K. population is rarely above adequate levels. It is now becoming clear that nutrient deficiencies during pregnancy can result in problems for the offspring, in both the short- and long-term. Early studies showed that lambs born to mothers on copper-deficient pastures developed ‘swayback’, with neurological and muscular symptoms that could not be reversed by postnatal supplementation. Our own findings have shown that prenatal iron deficiency results in increased postnatal blood pressure, even though the offspring have normal dietary iron levels from birth. These observations emphasize the importance of iron and copper in growth and development. Complicating the situation further is the fact that copper and iron are known to interact with each other in many ways, including absorption and intracellular transport. However, their interactions during the pregnancy appear to be more complex than during the non-pregnant state. In the present review, we examine the importance of these metals and their interactions, the consequences, both short- and long-term, of deficiency and consider some possible mechanisms whereby these effects may be generated.

Prospects for the Growth of Labor Productivity in the Transition to Postindustrial Technological Paradigms

2021 ◽  
pp. 56-59
Author(s):  
Leonid Basovskiy
Keyword(s):  
Labor Productivity ◽  
Productivity Growth ◽  
Developed Countries ◽  
Sixth Order ◽  
Short Term ◽  
Economic Dynamics ◽  
Russian Economy ◽  
Logical Order ◽  
Technological Paradigms

The purpose of the work was to determine the value of labor productivity pro-vided by the fourth, fifth and sixth technological modes. Based on the modeling of Kondratyev's cycles and technological structures in the economic dynamics of devel-oped countries, econometric estimates of labor productivity obtained. It has been estab-lished that during the transition from the fourth to the fifth technological order, the growth of labor productivity in developed countries is ensured from 2.0 to 8.0 times, an average of 4.8 times. In the transition from the fourth to the sixth technological order, the growth of labor productivity in developed countries is ensured from 6 to 17 times, an average of 10.1 times. In the transition from the fifth to the sixth order, the techno-logical order provides an increase in the forgiveness of labor from 1.5 to 3.2 times, on average 2.4 times. In the Russian economy, in the short term, with the transition to the fifth technological order, one can expect productivity growth from 2 to 8 times com-pared to the beginning of the 2000s. In the long term, in the Russian economy during the transition to the sixth technological order, one can expect productivity growth from 6 to 17 times compared to the beginning of the 2000s.

scholarly journals Smoking cessation in severe mental illness: combined long-term quit rates from the UK SCIMITAR trials programme

2019 ◽  
pp. 1-3 ◽  
Author(s):  
Simon Gilbody ◽  
Emily Peckham ◽  
Della Bailey ◽  
Catherine Arundel ◽  
Paul Heron ◽  
...  
Keyword(s):  
Mental Illness ◽  
Smoking Cessation ◽  
Severe Mental Illness ◽  
Short Term ◽  
Cessation Intervention ◽  
Term Trial ◽  
Short And Long Term ◽  
The Uk ◽  
Full Trial

Summary Smoking contributes to health inequalities for people with severe mental illness (SMI). Although smoking cessation interventions are effective in the short term, there are few long-term trial-based estimates of abstinence. The SCIMITAR trials programme includes the largest trial to date of a smoking cessation intervention for people with SMI, but this was underpowered to detect anticipated long-term quit rates. By pooling pilot and full-trial data we found that quit rates were maintained at 12 months (OR = 1.67, 95% CI 1.02–2.73, P = 0.04). Policymakers can now be confident that bespoke smoking cessation interventions produce successful short- and long-term quitting.

Migration Crisis and “Brexit”

2018 ◽  
pp. 92-110 ◽  
Author(s):  
William Outhwaite
Keyword(s):  
Political Culture ◽  
Prime Minister ◽  
British Politics ◽  
World War Two ◽  
World War ◽  
Short Term ◽  
Eu Membership ◽  
Migration Crisis ◽  
The Uk

The issue of migration bridges the divide between short-term and long-term explanations of Brexit.Short-term explanations stress the drift toward a referendum in British politics, the opportunistic miscalculation by a playboy prime minister, and the manipulation of the referendum vote by a grotesquely biased press and some of the same conspiratorial forces which secured Trump’s election. Longer-term explanations point to historical differences between the UK and (the rest of) Europe; the fact that the UK escaped defeat and occupation in World War Two; the distinctive legal system shared by England, Wales, and Northern Ireland (though not Scotland); and the UK’s majoritarian political culture. This chapter discusses in a comparative context. The contribution of a migration crisis to the UK’s EU membership and constitutional .

scholarly journals Using ‘subcement’ to simulate the long-term fatigue response of cemented femoral stems in a cadaver model: Could a novel preclinical screening test have caught the Exeter matt problem?

2009 ◽  
Vol 224 (4) ◽  
pp. 585-597 ◽  
Author(s):  
A Race ◽  
M A Miller ◽  
K A Mann
Keyword(s):  
Substantial Effect ◽  
Stair Climbing ◽  
Fatigue Properties ◽  
Short Term ◽  
Femoral Stems ◽  
Post Test ◽  
Implant Size ◽  
Clinical Consequences ◽  
Combining Information

Previously, cement was formulated with degraded fatigue properties (subcement) to simulate long-term fatigue in short-term cadaver tests. The present study determined the efficacy of subcement in a ‘preclinical’ test of a design change with known clinical consequences: the ‘polished’-to-‘matt’ transition of the Exeter stem (revision rates for polished stems were twice those for matt stems). Contemporary stems were bead blasted to give Ra = 1 μm (matt finish). Matt and polished stems were compared in cadaver pairs under stair-climbing loads (three pairs of size 1; three pairs of size 3). Stem micromotion was monitored during loading. Post-test transverse sections were examined for cement damage. Cyclic retroversion decreased for polished stems but increased for matt stems ( p<0.0001). The implant size had a substantial effect; retroversion of (larger) size-3 stems was half that of size-1 stems, and polished size-3 stems subsided 2.5 times more than the others. Cement damage measures were similar and open through-cracks occurred around both stems of two pairs. Stem retroversion within the mantle resulted in stem—cement gaps of 50—150 μm. Combining information on cyclic motion, cracks, and gaps, it was concluded that this test ‘predicted’ higher revision rates for matt stems (it also implied that polished size-3 stems might be superior to size-1 stems).

scholarly journals Protocol for an observational cohort study investigating personalised medicine for intensification of treatment in people with type 2 diabetes mellitus: the PERMIT study

BMJ Open ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. e046912
Author(s):  
Patrick Bidulka ◽  
Stephen O’Neill ◽  
Anirban Basu ◽  
Samantha Wilkinson ◽  
Richard J Silverwood ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Relative Effectiveness ◽  
Second Line ◽  
Short Term ◽  
Risk Profiles ◽  
The Uk

IntroductionFor people with type 2 diabetes mellitus (T2DM) who require an antidiabetic drug as an add-on to metformin, there is controversy about whether newer drug classes such as dipeptidyl peptidase-4 inhibitors (DPP4i) or sodium-glucose co-transporter-2 inhibitors (SGLT2i) reduce the risk of long-term complications compared with sulfonylureas (SU). There is widespread variation across National Health Service Clinical Commissioning Groups (CCGs) in drug choice for second-line treatment in part because National Institute for Health and Care Excellence guidelines do not specify a single preferred drug class, either overall or within specific patient subgroups. This study will evaluate the relative effectiveness of the three most common second-line treatments in the UK (SU, DPP4i and SGLT2i as add-ons to metformin) and help target treatments according to individual risk profiles.Methods and analysisThe study includes people with T2DM prescribed one of the second-line treatments-of-interest between 2014 and 2020 within the UK Clinical Practice Research Datalink linked with Hospital Episode Statistics and Office of National Statistics. We will use an instrumental variable (IV) method to estimate short-term and long-term relative effectiveness of second-line treatments according to individuals’ risk profiles. This method minimises bias from unmeasured confounders by exploiting the natural variation in second-line prescribing across CCGs as an IV for the choice of prescribed treatment. The primary outcome to assess short-term effectiveness will be change in haemoglobin A1c (%) 12 months after treatment initiation. Outcome measures to assess longer-term effectiveness (maximum ~6 years) will include microvascular and macrovascular complications, all-cause mortality and hospital admissions during follow-up.Ethics and disseminationThis study was approved by the Independent Scientific Advisory Committee (20-064) and the London School of Hygiene & Tropical Medicine Research Ethics Committee (21395). Results, codelists and other analysis code will be made available to patients, clinicians, policy-makers and researchers.

scholarly journals A Multi – Speed Europe, and the Peripherality of Poland

e-Finanse ◽  
2019 ◽  
Vol 15 (1) ◽  
pp. 30-44
Author(s):  
Mateusz Mierzejewski ◽  
Karolina Palimąka
Keyword(s):  
European Union ◽  
Business Cycles ◽  
Interest Rates ◽  
Inflation Rate ◽  
Developed Countries ◽  
The European Union ◽  
Short Term ◽  
Macroeconomic Indicators ◽  
Polish Economy

AbstractIn recent years, research on the synchronization of business cycles in economies has been undertaken more than once. This is a desirable phenomenon especially for the European Union. The aim of the article is to verify selected macroeconomic indicators that characterize the economies of countries belonging to the European Union in relation to Poland, thus presenting convergence of dynamic cycles of changes in socio-economic sphere indicators: inflation rate, unemployment rate, short-term interest rates, and GDP. For this purpose, a cross-spectral analysis was used which allows us to show the occurring fluctuations of different lengths, as well as to compare the strength of the relation of changes between selected indicators. According to the conducted analyses, it was noted that the Polish economy (in the perspective of long-term changes) is a determinant of changes for highly developed countries.

scholarly journals EP.FRI.552 Evaluating short term and long term outcome for patients undergoing emergency laparotomy in comparison to NELA mortality risk calculator

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Nourelhuda Darwish ◽  
Elsammoual Mohammed ◽  
Ibrahim Warrag ◽  
AdeelAbbas Dhahri ◽  
Bogdan Ivanov
Keyword(s):  
Mortality Risk ◽  
Emergency Laparotomy ◽  
Risk Calculator ◽  
Short Term ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Risk Of Death ◽  
Increased Risk ◽  
The Uk

Abstract Aim NELA is a project that was introduced in the UK since 2013, aiming to improve quality of care for patients undergoing emergency laparotomy.  NELA mortality risk calculator”was launched in 2017, which estimates the risk of death within 30 days of emergency laparotomy.  Our aim is to determine the short-term (30-day) and long-term (12 months) outcome in patients undergoing emergency laparotomy surgery and compare this with the estimated scores that were documented in the NELA website. Methods This is retrospective study involving patients who underwent emergency laparotomy surgery in the year of 2019. The primary outcome is to determine short-term (30-day) mortality. Results A total of 135 patients were included. The overall 30-day mortality was 8.8% (12/135). 55.77% (78/135) had NELA mortality score of &lt; 5%. Only 1 out of these (1.28%) died within 30 days. (4/78,5.12%) died in 6 to 12 months period of this group. 9 patients (11.53%) had NELA score &gt; 30%, of which 6 (66.66%) died within 30 days and 1 died within 6 months. 26.96% (48/135) had NELA scores 55 to 30%, 5 of them (10.41%) died within 30 days while 7 (14.58%) died within 6-12 months.  Patients with NELA scores more than 5% who survived the operation had higher chance of 30-day complications (25.58%, 11/43), when compared to those with scores less than 5% (11.68%, 9/77). Conclusion NELA mortality score has high accuracy especially if it was &gt;30%. In addition, high NELA scores are associated with increased risk of post operative complications.

Feedback trading strategies in international real estate markets

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Chrysanthi Balomenou ◽  
Vassilios Babalos ◽  
Dimitrios Vortelinos ◽  
Athanasios Koulakiotis
Keyword(s):  
Hong Kong ◽  
Real Estate ◽  
Short Term ◽  
Content Type ◽  
Real Estate Markets ◽  
The Real Estate ◽  
The Uk ◽  
The Impact ◽  
Feedback Trading

Purpose Motivated by recent evidence that securitized real estate returns exhibit higher levels of predictability than stock market returns and that feedback trading (FT) can induce returns autocorrelation and market volatility, the purpose of this study is to examine the impact of FT strategies on long-term market volatility of eight international real estate markets (UK, Germany, France, Italy, Sweden, Australia, Japan and Hong Kong). Design/methodology/approach Assuming that the return autocorrelation may vary over time and the impact of positive feedback trading (PFT) or negative feedback trading (NFT) could be a function of return volatility, the authors use a combination of a FT model and a fractionally integrated Generalized AutoRegressive Conditional Heteroskedasticity (GARCH) model. Findings The results are mixed, revealing that both PFT and NFT strategies persist. Specifically, the authors detect PFT in the real estate markets of France, Hong Kong and Italy as opposed to the real estate markets of Australia, Germany, Japan and Sweden where NFT was present. A noteworthy exception is the UK real estate market, with important and rational FT strategies to sustain. With respect to the long-term volatility persistence, this seems to capture the mean reversion of real estate returns in the UK and Hong Kong markets. In general, the results are not consistent with those reported in previous studies because NFT dominates PFT in the majority of real estate markets under consideration. Originality/value The main contribution of this study is the investigation of the link between short-term PFT or NFT and long-term volatility in eight international real estate markets, symmetrically. Particular attention has been given to the link between short-term FT and long-term volatility, by means of a fractionally integrated GARCH approach, a symmetric one. Moreover, investigating the relationship between returns’ volatility and investors’ strategies based on FT entails significant implications because real estate assets offer a good alternative investment for many investors and speculators.

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