scholarly journals The influence of dietary intake on the insulin-like growth factor (IGF) system across three ethnic groups: a population-based study

2003 ◽  
Vol 6 (2) ◽  
pp. 175-180 ◽  
Author(s):  
AH Heald ◽  
JE Cade ◽  
JK Cruickshank ◽  
S Anderson ◽  
A White ◽  
...  
Keyword(s):  
Growth Factor ◽  
Dietary Intake ◽  
Ethnic Group ◽  
Ethnic Groups ◽  
Protein Intake ◽  
Nutrient Intake ◽  
Fat Intake ◽  
Igf System ◽  
Igf I ◽  
Pakistani Origin

AbstractObjective:The insulin-like growth factor (IGF) system has been implicated in the aetiopathogenesis of cancer, cardiovascular disease and diabetes. Since dietary factors and ethnicity are considered contributory to the development of these diseases, we examined the IGF system in relation to nutritional intake by ethnic group.Design, subjects and setting:Dietary intake in 257 subjects of White European, African-Caribbean and Pakistani ethnic origin living in Manchester, UK was assessed using ethnic-group-specific food-frequency questionnaires to assess habitual nutrient intake over the previous 12 months. Fasting IGF-I, IGF-II and IGF-binding protein-1 (IGFBP-1) concentrations were determined and their relationship to specific dietary constituents was analysed.Results:Analysis by quintiles of nutrient intake showed a significant increase in circulating IGF-I concentration with increasing dietary fat intake (F for trend = 3.9, P < 0.01), saturated fat intake (F = 3.3, P = 0.01) and for protein intake (F = 4.2, P < 0.01). There was also a significant increase in IGF-II by quintiles of dietary protein intake (F = 2.7, P < 0.05). There was a trend for increasing IGF-I with increasing energy intake. The relationships between circulating concentration of IGFBP-1, an acute regulator of IGF action, and fat/protein intake were opposite to those for IGF-I and IGF-II. Multiple linear regression modelling showed that people of Pakistani origin and older subjects had lower levels of IGF-I (Pakistani origin vs. others, P < 0.001) (age, P < 0.001 for both). There was an independent inverse relationship between IGF-I and dietary carbohydrate intake (P = 0.036).Conclusions:This study provides evidence for a dietary contribution to regulation of the IGF system, although the effects of ethnicity on circulating IGF levels remain dominant. We propose that the IGF system's influences on cancer risk in specific ethnic groups are potentially modifiable by dietary intervention.

scholarly journals Dietary intake and the insulin-like growth factor system: effects of migration in two related populations in India and Britain with markedly different dietary intake

2005 ◽  
Vol 8 (6) ◽  
pp. 620-627 ◽  
Author(s):  
AH Heald ◽  
R Sharma ◽  
SG Anderson ◽  
A Vyas ◽  
K Siddals ◽  
...  
Keyword(s):  
Growth Factor ◽  
Dietary Intake ◽  
Total Energy ◽  
Macronutrient Intake ◽  
Fat Intake ◽  
Insulin Like Growth Factor ◽  
Igf System ◽  
Igf I ◽  
Total Fat ◽  
Igfbp 3

AbstractBackgroundThe insulin-like growth factor (IGF) system is implicated in the pathogenesis of diabetes and cardiovascular disease.ObjectiveWe report the effects of total energy intake on the IGF system in two populations with markedly different dietary macronutrient intake and cardiovascular event rate.Design, subjects and settingDietary macronutrient intake was measured in a specific Gujarati migrant community in Sandwell, UK (n = 205) compared with people still resident in the same villages of origin in India (n = 246). Fasting IGF-I, IGF-binding protein (IGFBP)-1 and IGFBP-3, insulin and glucose (0 and 2-hour) were measured.ResultsTotal energy and total fat intake were higher in UK migrants, as were IGFBP-3 and IGF-I (mean (95% confidence interval): 145.9 (138.1–153.6) vs. 100.9 (94.6–107.3) ng ml-1; F = 76.6, P < 0.001). IGFBP-1 was lower in UK migrants (29.5 (25.9–33.0) vs. 56.5 (50.6–62.5) μg l-1; F = 48.4, P < 0.001). At both sites, IGF-I correlated positively with total energy (Spearman's ρ = 0.45, P < 0.001) and total fat (ρ = 0.44, P < 0.001) as did IGFBP-3 with total energy (ρ = 0.21, P < 0.05) and fat (ρ = 0.26, P < 0.001). Conversely, in Indian Gujaratis, IGFBP-1 fell with increasing total energy (ρ = -0.27, P < 0.001) and fat intake (ρ = -0.26, P < 0.01) but not in UK Gujaratis. Multiple linear regression modelling showed that increasing quartiles of fat intake were associated with higher IGF-I (β = 0.42, P = 0.007) independent of age, body mass index, plasma insulin, fatty acids and 2-hour glucose.ConclusionIn these genetically similar groups, migration to the UK and adoption of a different diet is associated with marked changes in the IGF system, suggesting that environmental factors profoundly modulate serum concentrations and actions of IGFs.

scholarly journals Perbedaan Keragaman Pangan, Pola Asuh Makan, dan Asupan Zat Gizi Makro pada Balita dari Ibu Bekerja dan Ibu Tidak Bekerja

2021 ◽  
Vol 5 (3) ◽  
pp. 276
Author(s):  
Hesti Permata Sari ◽  
Lilis Permatasari ◽  
Widya Ayu Kurnia Putri
Keyword(s):  
Protein Intake ◽  
Nutrient Intake ◽  
Sampling Techniques ◽  
Fat Intake ◽  
Feeding Patterns ◽  
Child Feeding ◽  
Cross Sectional ◽  
Food Diversity ◽  
Business Women

Background: Toddlers are a group that is vulnerable to experiencing nutritional problems. The nutritional status of toddlers is very dependent on the role of caregivers, especially mothers. Business women have less time together with toddlers so that it will have an impact on mothers' attention to the growth and development of toddlers, child feeding patterns, food diversity, and macro-nutrient intake of toddlers. Research in Padang states that business women have a 1,3 times risk of experiencing malnutrition in children. Purpose: Know the differences in child feeding patterns, food diversity, and macro nutrient intake in toddlers from business women and housewife. Method: The design of this study was an observational analytic with cross sectional approach. The research was conducted on medium socioeconomic housing in Banyumas Regency. The sample are toddlers aged 12-59 months as many as 78 toddlers, taken using total sampling techniques. Data were statistically tested using independent T tests. Results: The results of study showed no differences in child feeding patterns (p = 0.605), food diversity (p = 0.767), energy intake (p = 0.483), protein intake (p = 0.806), fat intake (p = 0.787) and carbohydrate intake (p = 0.337) in toddlers from business women and housewife. Conclusions: There were no differences in child feeding patterns, food diversity, and macro nutrient intake in toddlers from business women and housewife.

IGF-binding protein-2 is induced during development of urinary bladder hypertrophy in the diabetic rat

1997 ◽  
Vol 272 (2) ◽  
pp. E297-E303 ◽  
Author(s):  
Y. Chen ◽  
B. Gustafsson ◽  
H. J. Arnqvist
Keyword(s):  
Growth Factor ◽  
Urinary Bladder ◽  
Messenger Rna ◽  
Diabetic Rat ◽  
Insulin Like Growth Factor ◽  
Igf System ◽  
Igf I ◽  
Igf Binding ◽  
Streptozotocin Induced Diabetes ◽  
Wet Weight

Because the locally produced insulin-like growth factor-binding proteins (IGFBP) may influence bladder hypertrophy, either directly or by their interaction with insulin-like growth factor I (IGF-I), we studied the IGF system during the development of urinary bladder hypertrophy in rats with streptozotocin-induced diabetes. Messenger RNA for IGF-I, IGFBP-2, and IGFBP-4 was determined by solution hybridization. The bladder wet weight was elevated after 7 days. DNA synthesis was increased and peaked at 2 days, whereas DNA content per bladder wet weight was decreased by 7 days. The IGF-I mRNA did not change during the first 7 days and then decreased, and IGFBP-4 mRNA was increased transiently on day 7. On the other hand, IGFBP-2 mRNA was significantly increased after 1 day (2-fold), peaked by 7 days (6.4-fold), and then declined to approximately 50% above control at the end of experiment. This was associated with an increased IGFBP-2 protein content. Our results suggest that both stretching of the bladder due to diuresis and the diabetic state contribute to changes of the IGF system in the hypertrophying bladder.

Physical capacity influences the response of insulin-like growth factor and its binding proteins to training

2002 ◽  
Vol 93 (5) ◽  
pp. 1669-1675 ◽  
Author(s):  
Lars Rosendal ◽  
Henning Langberg ◽  
Allan Flyvbjerg ◽  
Jan Frystyk ◽  
Hans Ørskov ◽  
...  
Keyword(s):  
Growth Factor ◽  
Physical Training ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Initial Training ◽  
Serum Samples ◽  
Fitness Level ◽  
Igf System ◽  
Igf I ◽  
Igfbp 3

The influence of initial training status on the response of circulating insulin-like growth factor (IGF) and its binding proteins (IGFBP) to prolonged physical training was studied in young men. It was hypothesized that highly standardized training would result in more extensive changes in the circulating IGF system in untrained subjects because of lower fitness level. Seven untrained (UT) and 12 well-trained (WT) individuals performed 11 wk of intense physical training (2–4 h daily). Fasting serum samples were analyzed for total and free IGF-I and -II, for IGFBP-1 to -4, as well as for IGFBP-3 proteolysis. Eleven weeks of physical training resulted in decreased levels of total IGF-I, free IGF-I, and IGFBP-4 in both the UT and WT groups. In the UT group, IGFBP-2 increased, IGFBP-3 decreased [from 4,255 ± 410 (baseline) to 3,896 ± 465 (SD) μg/l ( week 4); P < 0.05], and IGFBP-3 proteolysis increased [from 28 ± 8% (baseline) to 37 ± 7% ( week 4) and 39 ± 12% ( week 11); P < 0.05], whereas no significant changes were found in the WT group. In conclusion, intense physical training results in a marked influence on the IGF system and its binding proteins with generally more extensive changes seen in the untrained individuals. Also, prolonged physical training resulted in increased IGFBP-3 proteolysis in previously untrained individuals only, indicating that intense physical training affects trained and untrained individuals differently.

scholarly journals The Effect of Oral Glucose on Serum Free Insulin-Like Growth Factor-I and -II in Healthy Adults*

1997 ◽  
Vol 82 (9) ◽  
pp. 3124-3127 ◽  
Author(s):  
Jan Frystyk ◽  
Thorbjørn Grøfte ◽  
Christian Skjærbæk ◽  
Hans Ørskov
Keyword(s):  
Growth Factor ◽  
Healthy Subjects ◽  
Time Course ◽  
Oral Glucose ◽  
Insulin Like Growth Factor ◽  
Serum Samples ◽  
Cross Sectional ◽  
Igf System ◽  
Igf I ◽  
The Impact

Abstract Insulin-like growth factor (IGF) binding protein-I (IGFBP-1) has been suggested to regulate the availability of free IGF and the glucose lowering activity of the IGF-system in relation to fuel supply. Our recent observations of significant inverse correlations between free IGF-I and IGFBP-1 in cross-sectionally collected fasting serum samples support a possible physiological association between the peptides. To further study the impact of IGFBP-1 on free IGF levels and the possible participation of the IGF-system in glucose homeostasis, we studied the time course of changes in IGFBP-1 and free IGFs in 13 healthy subjects undergoing an oral glucose tolerance test (OGTT). Serum was collected every 30 min for 330 min. Glucose, insulin, and GH followed the expected patterns and had regained baseline levels at 270 min. Total IGF-I and free and total IGF-II remained unaltered. IGFBP-1 decreased significantly by 37–52% (P &lt; 0.05) from 150 to 210 min, whereafter the concentration gradually increased by 75% to a level that tended to be above baseline (P = 0.052). Free IGF-I decreased by 29–38% (P &lt; 0.05) at the end of the study (270–330 min). IGFBP-1 was inversely correlated to free IGF-I at baseline (r = −0.57; P &lt; 0.05), as well as during the OGTT (r = 0.66; P &lt; 0.0001). In contrast, free IGF-II was not correlated to IGFBP-1. Insulin, but not free IGF-I, correlated significantly with serum glucose (P &lt; 0.05). These results extend our previous findings of an inverse correlation between free IGF-I and IGFBP-1 in cross-sectional studies to include longitudinal observations, and thus further substantiates the hypothesis that IGFBP-1 is an important determinant of free IGF-I in vivo. Significant changes in free IGF-I were observed only in the late postprandial phase, when glucose and insulin were fully normalized, demonstrating that free IGFs probably do not participate in glucoregulation to any significant degree during an oral glucose load in healthy subjects.

scholarly journals Insulin-like growth factors-I and -II and insulin-like growth factor-binding protein-2 in dominant equine follicles during spring transition and the ovulatory season

Reproduction ◽  
2004 ◽  
Vol 128 (3) ◽  
pp. 321-329 ◽  
Author(s):  
E D Watson ◽  
S-E Bae ◽  
R Thomassen ◽  
S R M Thomson ◽  
K Woad ◽  
...  
Keyword(s):  
Growth Factor ◽  
Breeding Season ◽  
Messenger Rna ◽  
Threshold Level ◽  
Insulin Like Growth Factor ◽  
Igf System ◽  
Preovulatory Follicles ◽  
Igf I ◽  
Cyclical Growth ◽  
Somatotrophic Axis

The period between seasonal anoestrus and cyclicity is characterized in many mares by cyclical growth and regression of large dominant follicles. The insulin-like growth factor (IGF) system plays a key role in follicular growth and regression; therefore, we hypothesized that changes in the IGF system and its binding proteins would modulate onset of cyclicity in mares. Ovaries were obtained from pony mares on the day after detection of an actively growing 30 mm transitional anovulatory follicle, and also at the second or third oestrus of the breeding season on the day after the preovulatory follicle reached 30 mm in diameter. Size of dominant follicles at the time of removal was similar in transition (32 ± 0.8 mm) and at oestrus (34 ± 0.6 mm). IGF-I mRNA was present in granulosa cells, with low thecal expression, whereas IGF-II mRNA was confined to the theca layer. Expression of IGF-I and -II mRNAs, and intrafollicular concentrations of oestradiol, were lower (P < 0.01; paired t test) in transitional anovulatory follicles than in preovulatory follicles. Messenger RNA encoding IGFBP-2 was present in both theca and granulosa layers. Steady-state concentrations of mRNA encoding IGFBP-2 mRNA increased (P < 0.001) in theca in preovulatory follicles. Intrafollicular concentrations of IGFBP-2 were higher (P < 0.001) in transitional than in preovulatory follicles. The similarity in circulating concentrations of IGF-I in transitional and cyclic mares, suggested that the somatotrophic axis is not involved in transition from anovulatory to ovulatory cycles. The results suggest that the increased expression of IGF-I and -II mRNAs in preovulatory follicles, along with the decrease in IGFBP-2 concentrations, could increase the bioavailability of intrafollicular IGF in large follicles during the breeding season, and support our hypothesis that intrafollicular IGF bioavailability must exceed a threshold level before ovulation can occur.

scholarly journals Overview of Macro Nutrient Intake and Nutritional Status of Students at the Putri Hidayatullah Islamic Boarding School, Ternate City

2021 ◽  
Vol 9 (12) ◽  
pp. 13-21
Author(s):  
Hisdawati Abubakar ◽  
Yohannes Willi Helm ◽  
Nofiandri ◽  
Fadila
Keyword(s):  
Nutritional Status ◽  
Protein Intake ◽  
Nutrient Intake ◽  
Sampling Technique ◽  
Boarding School ◽  
Carbohydrate Intake ◽  
Physical Growth ◽  
Vulnerable Groups ◽  
Second Phase ◽  
Fat Intake

Adolescents are one of the nutritionally vulnerable groups. At this time, adolescents enter the second phase of rapid growth and then physical growth declines as young adults enter. Problems that arise in adolescents are undernutrition and overnutrition. One that is related to nutritional status is nutrient intake which is very influential on a person's nutritional status. Nutrient intake is influenced by eating habits and eating patterns of adolescents themselves. The purpose of this study was to determine the description of macronutrient intake and nutritional status at the Putri Hidayatullah Islamic Boarding School, Ternate City. The type of research used is descriptive research. The sampling technique used total sampling with a total sample of 29 people. The tools used were Microtoise, Bathroom Scale and form food recall 24. The results showed that the intake of macronutrients, as many as 28 people (96.6%) with less energy intake, 29 people (100.0%) with less protein intake, 16 people (55.2%) with more fat intake and 26 people (89.7%) with less carbohydrate intake. There were 25 people (86.2%) with normal nutritional status. It was concluded that from the results of the respondents had less protein intake and most had less energy and carbohydrate intake. On the other hand, most of these teenagers have good fat intake with normal nutritional status.

Expression of the insulin-like growth factor system in the hypokalemic rat kidney

1997 ◽  
Vol 272 (5) ◽  
pp. F661-F667 ◽  
Author(s):  
R. M. Rohan ◽  
T. G. Unterman ◽  
L. Liu ◽  
M. K. Hise
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Collecting Duct ◽  
Rat Kidney ◽  
Insulin Like Growth Factor ◽  
Distal Nephron ◽  
Igf System ◽  
Igf I ◽  
Igf Binding ◽  
Igf Binding Protein

We studied the renal expression of the insulin-like growth factor (IGF) system to gain a better perspective of its potential role in the hyperplastic adaptation of the distal nephron to potassium deficiency. Rats were pair fed 1% or 0.002% potassium diets for periods up to 10 days. IGF-I mRNA was diminished in potassium-deficient rats within 4 days, whereas mRNA for IGF binding protein-1 (IGFBP-1), a collecting duct-associated protein, was increased by day 7. At day 10 mRNA for IGFBP-1 in potassium-deficient animals averaged 2.07 +/- 0.53 (mean +/- SD, relative densitometry units) compared with 0.89 +/- 0.26 in control rats (n = 4, P = 0.002). Conversely, IGFBP-3, a binding protein whose mRNA has been localized to the interstitial compartment, averaged 2.40 +/- 0.02 in potassium-deficient rats and 4.77 +/- 0.05 in controls (n = 4, P < 0.03) at day 10 of treatment. Immunohistochemistry performed using a specific IGFBP-1 antibody revealed hyperplasia of distal nephron segments along with an increase in IGFBP-1 in potassium-depleted rats. These data suggest that IGFBP-1 may play an important role in the control of cellular adaptations in the hypokalemic rat kidney either directly by influencing cell migration or indirectly by localizing IGF-I to the distal nephron.

Effect of a high maternal dietary intake during mid-gestation on components of the utero-placental insulin-like growth factor (IGF) system in adolescent sheep with retarded placental development

Reproduction ◽  
2000 ◽  
pp. 407-416 ◽  
Author(s):  
TS Gadd ◽  
RP Aitken ◽  
JM Wallace ◽  
DC Wathes
Keyword(s):  
Growth Factor ◽  
Mrna Expression ◽  
Maternal Nutrition ◽  
Limit Of Detection ◽  
Receptor Expression ◽  
Insulin Like Growth Factor ◽  
Placental Development ◽  
Igf System ◽  
Igf I ◽  
Igfbp 3

The aim of the present study was to investigate the effects of administering a high plane diet during early to mid-gestation on the uterine and placental insulin-like growth factor (IGF) system and on systemic IGF-I concentrations in pregnant adolescent ewes with restricted placental growth. Embryos recovered from superovulated ewes inseminated by a single sire were transferred in singleton to the uterus of adolescent recipients. After transfer ewes were offered a high (H) or moderate (M) amount of a complete diet calculated to promote rapid or normal maternal growth rates, respectively. Five ewes from each group were switched from either M to H or H to M diets at day 52 of gestation. Maternal and fetal blood samples and placental tissues were collected from all animals at day 104. Ewes on the high plane diet from mid-gestation (HH, MH groups) had restricted placental mass (P < 0.01) and tended to have smaller fetuses. This was associated with increased maternal plasma IGF-I concentrations (P < 0.001). The pattern of expression of components of the IGF system in the uterus and placenta was studied by in situ hybridization. IGF-I mRNA concentrations were below the limit of detection. IGF-II mRNA expression was high in the fetal mesoderm and present in maternal stroma, but was not influenced by nutritional treatment. In contrast, IGF binding protein 1 (IGFBP-1) mRNA expression was higher (P < 0.05) and IGFBP-3 mRNA expression was lower (P < 0.05) in the endometrial glands of ewes in HH and MH groups. In the fetal trophoblast, IGFBP-3 mRNA expression was higher in the MH group. Type 1 IGF receptor expression was increased (P < 0. 01) in the luminal epithelium of the HM group and IGFBP-2 mRNA expression was highest in the placentome capsule of ewes in the HH group. Together, these results indicate that reprogramming of the uterine and placental IGF axis by maternal nutrition could contribute to placental growth retardation in growing adolescent sheep.

scholarly journals Seasonal effect on nutrient intake in adults living in Southern Brazil

2010 ◽  
Vol 26 (11) ◽  
pp. 2177-2187 ◽  
Author(s):  
Sinara Laurini Rossato ◽  
Maria Teresa Anselmo Olinto ◽  
Ruth Liane Henn ◽  
Luiz Antonio dos Anjos ◽  
Ana Weigert Bressan ◽  
...  
Keyword(s):  
Public Health ◽  
Dietary Intake ◽  
Public Health Policy ◽  
Nutrient Intake ◽  
Seasonal Effect ◽  
Policy Recommendations ◽  
Fat Intake ◽  
Southern Brazil ◽  
Dietary Recall ◽  
Total Fat

The objective of this study was to investigate the effect of seasonality on nutrient intake in healthy adults from the southernmost metropolitan area of Brazil. The dietary intake (24-hour dietary recall on six different days) in a sample of 162 adults (114 women), aged 20 to 69, was obtained during the year 2007. The nutrient intake was averaged for each season and adjusted for energy intake using the residual method. The effect of season on energy, macro and micro-nutrient intake was investigated based on the Generalized Estimate Equations (GEE) model. There were statistically significant differences between seasons for carbohydrate and total fat intake after controlling for gender, age, education, and interactions. In summer carbohydrate intake was higher than other seasons while the total fat intake was lower. These findings highlight the importance of considering seasonal variations not only for evaluating dietary intake but also nutrition and public health policy recommendations, particularly in adult populations living in temperate regions.

Sign in / Sign up

Export Citation Format

Share Document