scholarly journals Aqueous extracts of husks of Plantago ovata reduce hyperglycaemia in type 1 and type 2 diabetes by inhibition of intestinal glucose absorption

2006 ◽  
Vol 96 (01) ◽  
pp. 131 ◽  
Author(s):  
J. M. A. Hannan ◽  
L. Ali ◽  
J. Khaleque ◽  
M. Akhter ◽  
P. R. Flatt ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Absorption ◽  
Aqueous Extracts ◽  
Plantago Ovata ◽  
Intestinal Glucose Absorption

Metformin reduces the rate of small intestinal glucose absorption in type 2 diabetes

2016 ◽  
Vol 19 (2) ◽  
pp. 290-293 ◽  
Author(s):  
Tongzhi Wu ◽  
Cong Xie ◽  
Hang Wu ◽  
Karen L. Jones ◽  
Michael Horowitz ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Absorption ◽  
Intestinal Glucose Absorption ◽  
Small Intestinal

Medical Herbs and the Treatment of Diabetes Mellitus

2021 ◽  
pp. 48-73
Author(s):  
Donovan Anthony McGrowder ◽  
Fabian G. Miller ◽  
Chukwuemeka Nwokocha ◽  
Cameil F. Wilson-Clarke ◽  
Melisa Anderson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Glucose Absorption ◽  
Medicinal Herbs ◽  
Subsequent Increase ◽  
Treatment Of Diabetes ◽  
Intestinal Glucose Absorption ◽  
Oral Hypoglycemic Drugs

Diabetes mellitus is a chronic metabolic disorder that affects millions of persons worldwide, and if uncontrolled may cause cardiovascular disease, retinopathy, or chronic kidney disease. Effective therapeutic management of diabetes mellitus involves the use of mainly oral hypoglycemic drugs whose mechanism of action includes improved insulin secretion, reduced insulin resistance, or increased glucose uptake. There is growing exploration of medicinal herbs as potential therapeutic sources for the management of type 2 diabetes mellitus and compared with conventional oral hypoglycemic drugs they have little or no side effects. The aim of this review is to provide up-to-date information on potential medicinal herbs that have demonstrated anti-hyperglycemic activity through either increased secretion of insulin from pancreatic β-cells, reduction of insulin resistance with subsequent increase in insulin sensitivity, or inhibition of intestinal glucose absorption via decreased α-glucosidase activity.

scholarly journals Type 2 Diabetes Impairs Splanchnic Uptake of Glucose but Does Not Alter Intestinal Glucose Absorption During Enteral Glucose Feeding

Diabetes ◽  
2001 ◽  
Vol 50 (6) ◽  
pp. 1351-1362 ◽  
Author(s):  
Ananda Basu ◽  
Rita Basu ◽  
Pankaj Shah ◽  
Adrian Vella ◽  
C. Michael Johnson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Absorption ◽  
Glucose Feeding ◽  
Intestinal Glucose Absorption

scholarly journals Berberine Decreases Intestinal GLUT2 Translocation and Reduces Intestinal Glucose Absorption in Mice

2021 ◽  
Vol 23 (1) ◽  
pp. 327
Author(s):  
Min Zhang ◽  
Hongyan Yang ◽  
Erwan Yang ◽  
Jia Li ◽  
Ling Dong
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Brush Border Membrane ◽  
Intestinal Epithelial Cells ◽  
Glucose Absorption ◽  
Postprandial Hyperglycemia ◽  
Intestinal Epithelial ◽  
Diabetic Mice ◽  
Intestinal Glucose Absorption

Postprandial hyperglycemia is an important causative factor of type 2 diabetes mellitus, and permanent localization of intestinal GLUT2 in the brush border membrane is an important reason of postprandial hyperglycemia. Berberine, a small molecule derived from Coptidis rhizome, has been found to be potent at lowering blood glucose, but how berberine lowers postprandial blood glucose is still elusive. Here, we investigated the effect of berberine on intestinal glucose transporter 2 (GLUT2) translocation and intestinal glucose absorption in type 2 diabetes mouse model. Type 2 diabetes was induced by feeding of a high-fat diet and injection of streptozotocin and diabetic mice were treated with berberine for 6 weeks. The effects of berberine on intestinal glucose transport and GLUT2 translocation were accessed in isolated intestines and intestinal epithelial cells (IEC-6), respectively. We found that berberine treatment improved glucose tolerance and systemic insulin sensitivity in diabetic mice. Furthermore, berberine decreased intestinal glucose transport and inhibited GLUT2 translocation from cytoplasm to brush border membrane in intestinal epithelial cells. Mechanistically, berberine inhibited intestinal insulin-like growth factor 1 (IGF-1R) phosphorylation and thus reduced localization of PLC-β2 in the membrane, leading to decreased GLUT2 translocation. These results suggest that berberine reduces intestinal glucose absorption through inhibiting IGF-1R-PLC-β2-GLUT2 signal pathway.

Type 2 Diabetes Overtakes Type 1 in Hispanic Girls

2008 ◽  
Vol 38 (15) ◽  
pp. 18
Author(s):  
SHERRY BOSCHERT
Keyword(s):  
Type 2 Diabetes

Causes of diabetic ketoacidosis: type 1 diabetes versus type 2 diabetes

2017 ◽  
Author(s):  
Marwa Omri ◽  
Rayene Ben Mohamed ◽  
Imen Rezgani ◽  
Sana Mhidhi ◽  
Aroua Temessek ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Diabetic Ketoacidosis
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