scholarly journals The influence of erythrocyte folate and serum vitamin B12status on birth weight

2005 ◽  
Vol 93 (5) ◽  
pp. 593-599 ◽  
Author(s):  
Caroline L. Relton ◽  
Mark S. Pearce ◽  
Louise Parker
Keyword(s):  
Birth Weight ◽  
Maternal Age ◽  
Serum Vitamin ◽  
Vitamin B ◽  
Maternal Vitamin ◽  
Confounding Variables ◽  
Standardized Regression Coefficients ◽  
Erythrocyte Folate ◽  
Infant Birth ◽  
The Relationship

The extent to which maternal folate and vitamin B12modulate infant birth weight is unclear. The present study investigated mothers in early gestation (mean 11·5 (sd 5·8) weeks) and neonates, at delivery. Erythrocyte (RBC) folate (mothers:n683; neonates:n614) and vitamin B12(mothers:n534; neonates:n614) were measured. Data on smoking habits were available for 44 % of pregnancies (n443). The relationship between vitamin levels and birth weight standardized for gender and gestational age was investigated, using linear regression and adjusting for possible confounding variables (maternal age, parity). Results are presented as standardized regression coefficients (b). Increasing maternal age was associated with elevated RBC folate (b0·11 (95 % CI 0·08, 0·15),P<0·001;n674) and smoking was associated with a decrease in maternal RBC folate (b−1·38 (95 % CI −1·92, −0·86),P=0·001;n319). Neonatal RBC folate was predicted by maternal RBC folate (b0·08 (95 % CI 0·04, 0·11),P=0·001;n315) and maternal vitamin B12(b0·08 (95 % CI 0·01, 0·16),P=0·02;n252). Smoking influenced maternal vitamin B12status (b−0·88 (95 % CI −1·49, −0·27),P=0·005;n231). Using univariate regression, smoking significantly influenced infant birth weight (b−2·15 (95 % CI −3·24, −1·04),P<0·001;n437). However, the effect of smoking on birth weight was statistically non-significant when considered in a multivariate regression model, leaving maternal RBC folate as the only significant predictor of birth weight (b0·25 (95 % CI 0·08, 0·42),P=0·005;n145). These findings suggest that maternal folate status is an important determinant of infant birth weight. The combined effects of smoking and reduced RBC status on birth weight require further investigation.

Maternal Marijuana Exposure and Birth Weight: An Observational Study Surrounding Recreational Marijuana Legalization

2019 ◽  
Vol 38 (01) ◽  
pp. 065-075 ◽  
Author(s):  
Heather L. Straub ◽  
Jin Mou ◽  
Kathryn J. Drennan ◽  
Bethann M. Pflugeisen
Keyword(s):  
Birth Weight ◽  
Washington State ◽  
Urine Drug Screen ◽  
Multivariate Models ◽  
Marijuana Legalization ◽  
Urine Drug ◽  
Recreational Marijuana ◽  
Good Samaritan Hospital ◽  
Infant Birth ◽  
The Relationship

Abstract Objective This study aimed to study the relationship between prenatal marijuana and infant birth weight using natural cohorts established before, during and after the 20-month lapse between legalization and legal recreational sales in Washington State. Study Design Over 5 years, 5,343 pregnant women with documented urine drug screen (UDS) results delivered at Tacoma General Hospital or Good Samaritan Hospital. Maternal medical data were extracted for three delivery cohorts established based on before (T1), during (T2), and after legalization (T3) of recreational marijuana and legalized availability. Univariate and multivariate models were created to study marijuana exposure on infants' birth weight. Results Marijuana exposure increased the risk of low birth weight (LBW; odds ratio [OR] = 1.42, 95% confidence interval [CI]: 1.01–2.01). This was more pronounced in full-term babies (OR = 1.72, 95% CI: 1.10–2.69), and was independently associated with a higher risk for small for gestational age (SGA; OR = 1.51, 95% CI: 1.49–1.53). The associations between marijuana exposure and SGA were maintained in cohort-specific models (OR = 1.53, 95% CI: 1.01–2.32 for T2, and OR = 1.43, 95% CI: 1.01–2.02 for T3, respectively). Conclusion Marijuana exposure verified by UDS was associated with LBW and SGA. However, recreational marijuana legalization and availability did not have direct impact on newborns' risk of LBW or SGA.

scholarly journals The role of parathyroid hormone during pregnancy on the relationship between maternal vitamin D deficiency and fetal growth restriction: a prospective birth cohort study

2020 ◽  
Vol 124 (4) ◽  
pp. 432-439
Author(s):  
Deng-Hong Meng ◽  
Ying Zhang ◽  
Shuang-Shuang Ma ◽  
Hong-Lin Hu ◽  
Jing-Jing Li ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Parathyroid Hormone ◽  
Birth Weight ◽  
Fetal Growth ◽  
Birth Cohort Study ◽  
Maternal Vitamin ◽  
The Relationship ◽  
Prospective Birth Cohort ◽  
Prospective Birth Cohort Study

AbstractPrevious studies have shown conflicting findings regarding the relationship between maternal vitamin D deficiency (VDD) and fetal growth restriction (FGR). We hypothesised that parathyroid hormone (PTH) may be an underlying factor relevant to this potential association. In a prospective birth cohort study, descriptive statistics were evaluated for the demographic characteristics of 3407 pregnancies in the second trimester from three antenatal clinics in Hefei, China. The association of the combined status of vitamin D and PTH with birth weight and the risk of small for gestational age (SGA) was assessed by a multivariate linear and binary logistic regression. We found that declined status of 25-hydroxyvitamin D is associated with lower birth weight (for moderate VDD: adjusted β = −49·4 g, 95 % CI −91·1, −7·8, P < 0·05; for severe VDD: adjusted β = −79·8 g, 95 % CI −127·2, −32·5, P < 0·01), as well as ascended levels of PTH (for elevated PTH: adjusted β = −44·5 g, 95 % CI −82·6, −6·4, P < 0·05). Compared with the non-VDD group with non-elevated PTH, pregnancies with severe VDD and elevated PTH had the lowest neonatal birth weight (adjusted β = −124·7 g, 95 % CI −194·6, −54·8, P < 0·001) and the highest risk of SGA (adjusted risk ratio (RR) = 3·36, 95 % CI 1·41, 8·03, P < 0·01). Notably, the highest risk of less Ca supplementation was founded in severe VDD group with elevated PTH (adjusted RR = 4·67, 95 % CI 2·78, 7·85, P < 0·001). In conclusion, elevated PTH induced by less Ca supplementation would further aggravate the risk of FGR in pregnancies with severe VDD through impaired maternal Ca metabolism homoeostasis.

scholarly journals Perinatal circumstances and risk of offspring suicide

2006 ◽  
Vol 189 (6) ◽  
pp. 502-507 ◽  
Author(s):  
Daniel V. Riordan ◽  
Sivasubramaniam Selvaraj ◽  
Cameron Stark ◽  
Julie S. E. Gilbert
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Linked Data ◽  
Maternal Age ◽  
Suicide Risk ◽  
Cox Regression ◽  
Maternal Parity ◽  
Self Harm ◽  
Independent Association ◽  
The Relationship

BackgroundA higher risk of suicide has been associated with low birth weight in one study, but not yet replicated. Higher birth order has been associated with self-harm, but not with suicide.AimsTo examine the relationship between perinatal circumstances and subsequent young adult suicide in Scotland.MethodUsing linked data from the Scottish Morbidity Record and Scottish death records, a birth cohort of 1 061 830 people was followed-up for a mean of 25.1 years. Data were analysed using Cox regression.ResultsHigher maternal parity, younger maternal age (<25 years), non-professional parental occupations and low birth weight (<2500 g) were independently associated with higher suicide risk of offspring as young adults. There was no independent association with gestational age.ConclusionsOur findings provide support for the influence of maternal circumstance and foetal experience on subsequent mental health.

scholarly journals Haematological studies on vegans

1978 ◽  
Vol 40 (1) ◽  
pp. 9-15 ◽  
Author(s):  
T. A. B. Sanders ◽  
F. R. Ellis ◽  
J. W. T. Dickerson
Keyword(s):  
Haemoglobin Concentration ◽  
Serum Vitamin ◽  
Mean Value ◽  
Serum Folate ◽  
Vitamin B ◽  
Normal Range ◽  
Blood Formation ◽  
Mean Corpuscular Haemoglobin ◽  
Erythrocyte Folate ◽  
The Mean

1. The concentrations of vitamin B12 and folate in the serum and folate in the erythrocytes were determined and full blood counts made on a series of caucasian vegans and omnivore controls.2. The blood counts and films were normal in all the vegans and no subject had a haemoglobin concentration below the lower limit of normality.3. Although within the normal range, male but not female vegans had lower values for erythrocyte counts and higher values for mean corpuscular volume and mean corpuscular haemoglobin than their controls regardless of whether they were taking vitamin B12 supplements or not.4. The mean serum vitamin B12 concentration was lower in the vegans not taking vitamin B12 supplements and in those using foods supplemented with the vitamin than in the controls, but in no subject was it below 80 ng/l.5. The serum folate concentrations were higher in the vegans than in their controls. The mean value for erythrocyte folate tended to be greater in the vegans not taking vitamin B12 supplements. No subject had an erythrocyte folate concentration of less than 100μg/l.6. It is concluded that megaloblastic anaemia is very rare in caucasian vegans and that a diet consisting entirely of plant foods is generally adequate to promote normal blood formation providing it is composed of a mixture of unrefined cereals, pulses, nuts, fruit and vegetables and is supplemented with vitamin B12.

scholarly journals HUBUNGAN USIA IBU BERSALIN, PARITAS DAN BERAT BAYI LAHIR DENGAN KEJADIAN PARTUS TAK MAJU

2021 ◽  
Vol 5 (1) ◽  
pp. 215
Author(s):  
Paskalia Tri Kurniati
Keyword(s):  
Birth Weight ◽  
Maternal Age ◽  
P Value ◽  
Early Screening ◽  
Cross Sectional ◽  
Maternal Deaths ◽  
Keywords Birth Weight ◽  
Prolonged Labor ◽  
Cross Sectional Design ◽  
The Relationship

About 9% of maternal deaths are due to complications during pregnancy, childbirth and after delivery. The cause of maternal death was bleeding 30.1%, hypertension 26.9%, infection 5.6%, abortion 1.6%, prolonged labor 1.8% and others 34.5%. Data obtained at the Ade Mohammad Djoen Regional Hospital for the last 3 years has seen an increase in cases of prolonged labor. In 2017 there were 37 cases, in 2018 there were 39 cases, and in 2019 there were 48 cases. The purpose of this study was to determine the relationship between maternal age, parity and birth weight with the incidence of non-progressive labor. The research method is quantitative analytic with cross sectional design, using a retropective approach. The results of this study showed a relationship between maternal age and the incidence of prolonged labor with (p value = 0.008 (p <0.05) and an OR value of 2,250, which means that the age of mothers who gave birth who was <20 years or> 35 years had a risk of developing non-progressive labor 2,250. There is a relationship between parity and the incidence of underdeveloped labor (p value = 0.026 (p <0.05) with an OR value of 1.977, which means parity with the number of deliveries 1 or> 3 has a risk of developing non-progressive labor by 1.977 times. Between the birth weight and the incidence of non-progressive labor with (p value = 0.040 (p <0.05) with an OR value of 1.953, which means that the birth weight at risk >4000 grams has a 1.953 times greater risk of developing prolonged labor. This needs to increase service innovation in dealing with emergencies of underdeveloped labor, one of which is through early screening steps with antenatal care so that cases of prolonged labor can be prevented. Keywords              : birth weight; Prolonged labor; maternal age; parity AbstrakSekitar 9% kematian maternal akibat komplikasi selama kehamilan, persalinan dan setelah persalinan. Penyebab kematian ibu perdarahan 30,1%, hipertensi 26,9%, infeksi 5,6%, abortus 1,6%, partus tak maju 1,8% dan lain-lain 34,5%. Data yang diperoleh di RSUD Ade Mohammad Djoen selama 3 tahun terakhir terjadi peningkatan kasus partus tak maju. Tahun 2017 ada 37 kasus, tahun 2018 ada 39 kasus, dan tahun 2019 menjadi 48 kasus.  Tujuan penelitian ini mengetahui Hubungan Usia Ibu Bersalin, Paritas dan Berat Bayi Lahir dengan Kejadian Partus Tak Maju. Metode Penelitian adalah analitik kuantitatif dengan desain cross sectional, menggunakan pendekatan retropektif. Hasil penelitian ini ada hubungan usia ibu bersalin dengan kejadian partus tak maju dengan (p value = 0,008 (p < 0,05) dan nilai OR 2,250 yang berarti usia ibu bersalin yang <20 Tahun atau >35 tahun mempunyai resiko terjadinya partus tak maju 2,250 kali lebih besar. Ada hubungan paritas dengan kejadian partus tak maju dengan (p value = 0,026 (p < 0,05) dengan nilai OR 1,977 yang artinya paritas dengan jumlah persalinan 1 atau >3  mempunyai resiko terjadinya partus tak maju 1,977 kali. Ada hubungan antara berat bayi lahir dengan kejadian partus tak maju dengan (p value = 0,040 (p < 0,05) dengan nilai OR 1,953 yang artinya berat bayi lahir yang beresiko >4000 gram  mempunyai resiko terjadinya partus tak maju 1,953 kali lebih besar. Saran dalam penelitian ini perlu meningkatkan inovasi pelayanan dalam menangani kegawatdaruratan partus tak maju salah satunya melalui langkah penapisan sejak awal dengan pemeriksaan kehamilan sehingga kasus partus tak maju dapat dicegah.

scholarly journals Hubungan Umur Ibu dengan Kejadian Persalinan Prematur di Wilayah Kerja Puskesmas Kaliangkrik Kabupaten Magelang Tahun 2012

2014 ◽  
Vol 1 (2) ◽  
pp. 91
Author(s):  
Fatimah Sari ◽  
Evy Ernawati ◽  
Indartik Indartik
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Preterm Labor ◽  
Maternal Age ◽  
Sampling Technique ◽  
The Body ◽  
P Value ◽  
Low Birth Weight Infants ◽  
Cross Sectional ◽  
The Relationship

Background: One of the most common causes of death of neonates are low birth weight (LBW) either at term or preterm (premature). As a result of the premature births, children born will experience a variety of health problems due to lack of maturation of the fetus at birth which resulted in many organs of the body that have not been able to work perfectly. factors that can lead to preterm labor (preterm) or low birth weight infants is mother's first factor is less than 20 years of age or over 35 years . Method: This study aims to determine the relationship between maternal age with the incidence of preterm labor. Objective: This research is the type of observational analytic study with cross sectional approach. The sampling technique using saturated sample and the number of samples in this study were 75 respondents. Result: The results showed no association with maternal age on the incidence of preterm labor Puskesmas Kaliangkrik Magelang Regency in 2012 with a p value of 0.000 (0.000 < 0.05) and the relationship is strong enough that the value of the Contingency Coefficient .431. Conclusion: There is a relationship with the mother's age incidence of preterm labor.

scholarly journals HUBUNGAN TINGGI BADAN ORANG TUA DAN BERAT BADAN LAHIR DENGAN PANJANG BADAN LAHIR BAYI DI KABUPATEN SLEMAN

2018 ◽  
pp. 168-173
Author(s):  
Maria Dolorosa P. Sogen ◽  
Budiyanti Wiboworini ◽  
Ari Natalia Probandari
Keyword(s):  
Birth Weight ◽  
Body Length ◽  
Parent Body ◽  
Maternal Weight ◽  
Cohort Design ◽  
Length Data ◽  
Relationship Of ◽  
Infant Birth ◽  
The Relationship

ABSTRAK Panjang badan lahir menggambarkan laju pertumbuhan janin selama dalam kandungan. Faktor genetik yakni tinggi badan orang tua juga berperan dalam menentukan panjang badan bayi lahir. Jika tinggi badan orang tua pendek karena faktor genetik maka akan diwariskan kepada anak, akan tetapi jika tinggi badan orang tua pendek karena nutrisi, maka tidak diwariskan kepada anak. Berat badan lahir bayi merupakan faktor penting yang berhubungan dengan panjang badan lahir. Bayi dengan berat badan lahir rendah beririko memiliki panjang badan yang kurang. Tujuan penelitian adalah menganalisis hubungan tinggi badan orang tua dan berat badan lahir bayi dengan panjang badan lahir bayi di Kabupaten Sleman. Jenis penelitian ini adalah observasional analitik dengan desain cohort retrospektif. Subjek penelitian sebanyak 76 ibu hamil trisemester III. Data tinggi badan orang tua diukur menggunakan microtoice dengan ketelitian 0,1 cm data berat badan lahir bayi diukur menggunakan baby scale dengan ketelitian 0,1 gram, dan data panjang badan lahir diukur menggunakan length board dengan ketelitian 0.1 cm. Analisis data menggunakan korelasi spearman dan regresi linier ganda dengan nilai p<0,05. Hasil analisis rank spearman hubungan tinggi badan ayah dengan panjang badan lahir p= 0,019 dan hubungan tinggi badan ibu dengan panjang badan lahir p=0,219, berat badan lahir dengan panjang badan lahir p=0,005. Analisis regresi linier ganda menunjukan pengaruh tinggi badan ayah (B=0,054, p=0,132) berat badan lahir (B= 1,083, P=0,201), dengan panjang badan lahir. Kesimpulan secara bersama-sama ada hubungan antara tinggi badan orang tua dan berat badan lahir bayi dengan panjang badan lahir bayi.   Kata kunci: tinggi badan orang tua, berat lahir, Ibu hamil trimester III, panjang badan.       ABSTRACT The length of the birth body is the growth rate of the fetus in the womb. Maternal weight gain during pregnancy is one of the factors that grows fetus in the womb. The genetic factor height of the parents also play a role in determining the length of the baby's body was born. If the height of the parent body is short due to genetic factors it will be inherited to the child, will if the height of the parent body short because of nutrition, it is not inherited to the child. The purpose of this study was to analyze the relationship of height parent and baby,s birth weight with baby's long-term birth in Sleman District. The method is was analytic observational with retrospective cohort design. Subjek of this study was 76 pregnant women, trismester III. The height of the parents is measured using microtoice with a precision of 0.1 cm, infant birth weight measured using baby scale with a precision 0,1 gram. Body length data was measured using length board with a precision 0.1 cm. Data analysis used spearman correlation and multiple linear regression with p<0,05. Results: . Result of rank spearman analysis correlation of father’s height with length of the baby’s birth p= 0,019, correlation of mother’s height with length of the baby’s birth p= 0,219, correlation of baby’s birth weight with length of the baby’s birth p=0,005. Result of multiple regression linier analysis showed that the effect of the effect of father’s height (B=0,054, p=0,132), birth weight (B= 1,083, P=0,201) with length of the baby’s birth. Conclusion:: father's height and baby’s birth weght had correlation with length of the baby's birth. Keywords: parenting height, birth weight, pregnancy trimester III, body length.

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