scholarly journals Stunted children gain less lean body mass and more fat mass than their non-stunted counterparts: a prospective study

2004 ◽  
Vol 92 (5) ◽  
pp. 819-825 ◽  
Author(s):  
P. A. Martins ◽  
D. J. Hoffman ◽  
M. T. B. Fernandes ◽  
C. R. Nascimento ◽  
S. B. Roberts ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Fat ◽  
Fat Mass ◽  
Lean Mass ◽  
Overweight And Obesity ◽  
Significant Difference ◽  
Normal Stature ◽  
Baseline Values ◽  
A Prospective Study

The aim of the present study was to analyse the changes in body composition of stunted children during a follow-up period and to test the hypothesis of a tendency to accumulate body fat as a consequence of undernutrition early in life. We selected fifty boys and girls aged 11 to 15, who were residents of slums in São Paulo, Brazil. Twenty were stunted (S) and thirty had normal stature (NS). The children's nutritional status and body composition were assessed through anthropometry and dual-energy X-ray absorptiometry, at the beginning of the present study and after 3 years, and changes in lean mass (LM and LM%) and fat mass (FM and FM%) were calculated. Stunted boys accumulated more body fat (FM%: S=1·62%, NS=−3·40%;P=0·003) and gained less lean mass (LM%: S=−1·46, NS=3·21%;P=0·004). Stunted girls gained less lean mass (S=7·87 kg, NS=11·96 kg;P=0·032) and had significantly higher values of FM% at follow-up when compared with their baseline values (P=0·008), whereas non-stunted girls had a non-significant difference in FM% over time (P=0·386). These findings are important to understand the factors involved in the increased prevalence of overweight and obesity among poor populations, which appear to be associated with hunger during infancy and/or childhood.

scholarly journals Longitudinal changes in body composition and waist circumference by self-reported levels of physical activity in leisure among adolescents: the Tromsø study, Fit Futures

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Nils Abel Aars ◽  
Bjarne K. Jacobsen ◽  
Bente Morseth ◽  
Nina Emaus ◽  
Sameline Grimsgaard
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Waist Circumference ◽  
Fat Mass ◽  
Lean Mass ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
First Year ◽  
Fat Mass Index

Abstract Background It is not clear how physical activity affects body composition in adolescents. Physical activity levels are often reduced during this period, and the relative proportion of body fat mass and lean mass undergo natural changes in growing adolescents. We aimed to examine whether self-reported physical activity in leisure time at baseline or change in activity during follow-up affect changes in four measures of body composition; body mass index (kg/m2), waist circumference, fat mass index (fat mass in kg/m2) and lean mass index (lean mass in kg/m2). Methods We used data from the Tromsø Study Fit Futures, which invited all first year students in upper secondary high school in two municipalities in northern Norway in 2010–2011. They were reexamined in 2012–2013. Longitudinal data was available for 292 boys and 354 girls. We used multiple linear regression analyses to assess whether self-reported level of physical activity in leisure time at baseline predicted changes in body composition, and analysis of covariance to assess the effects of change in level of activity during follow-up on change in body composition. All analyses were performed sex-specific, and a p-value of < 0.05 was considered statistically significant. Results There were no associations between self-reported leisure time physical activity in the first year of upper secondary high school and changes in any of the considered measure of body composition after 2 years of follow up, with the exception of waist circumference in boys (p = 0.05). In boys, change in fat mass index differed significantly between groups of activity change (p < 0.01), with boys adopting activity or remaining physically active having less increase in fat mass index than the consistently inactive. In girls, change in lean mass index differed significantly between groups of activity change (p = 0.04), with girls adopting physical activity having the highest increase. Conclusions Self-reported leisure time physical activity does not predict changes in body composition in adolescents after 2 years of follow up. Change in the level of physical activity is associated with change in fat mass index in boys and lean mass index in girls.

scholarly journals Body weight at 10 years of age and change in body composition between 8 and 10 years of age were related to survival in a longitudinal study of 39 Labrador retriever dogs

2019 ◽  
Vol 61 (1) ◽  
Author(s):  
Johanna Christina Penell ◽  
David Mark Morgan ◽  
Penny Watson ◽  
Stuart Carmichael ◽  
Vicki Jean Adams
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
End Of Life ◽  
Fat Mass ◽  
Lean Mass ◽  
Coat Colour ◽  
Overweight And Obesity ◽  
Time Varying ◽  
Cohort Study Design ◽  
Changes Over Time

Abstract Background Overweight and obesity have been adversely associated with longevity in dogs but there is scarce knowledge on the relation between body composition and lifespan. We aimed to investigate the effects of body composition, and within-dog changes over time, on survival in adult Labradors using a prospective cohort study design. The dogs had a median age of 6.5 years at study start and were kept in similar housing and management conditions throughout. The effects of the various predictors, including the effect of individual monthly-recorded change in body weight as a time varying covariate, were evaluated using survival analysis. Results All dogs were followed to end-of-life; median age at end-of-life was 14.0 years. Body composition was measured annually with dual-energy x-ray absorptiometer (DEXA) scans between 6.2 and 17.0  years. All 39 dogs had DEXA recorded at 8, 9 and 10 years of age. During the study the mean (± SD) percent of fat (PF) and lean mass (PL) was 32.8 (± 5.6) and 64.2 (± 5.5) %, respectively, with a mean lean:fat ratio (LFR) of 2.1 (± 0.6); body weight (BW) varied from 17.5 to 44.0 kg with a mean BW change of 9.9 kg (± 3.0). There was increased hazard of dying for every kg increase in BW at 10 years of age; for each additional kg of BW at 10 years, dogs had a 19% higher hazard (HR = 1.19, P = 0.004). For the change in both lean mass (LM) and LFR variables, it was protective to have a higher lean and/or lower fat mass (FM) at 10 years of age compared to 8 years of age, although the HR for change in LM was very close to 1.0. For age at study start, older dogs had an increased hazard. There was no observed effect for the potential confounders sex, coat colour and height at shoulders, or of the time-varying covariate. Conclusions These results suggest that even rather late-life control efforts on body weight and the relationship between lean and fat mass may influence survival in dogs. Such “windows of opportunity” can be used to develop healthcare strategies that would help promote an increased healthspan in dogs.

scholarly journals Serum FSH Is Associated with BMD, Bone Marrow Adiposity and Body Composition in the AGES-Reykjavik Study of Older Adults

2020 ◽  
Author(s):  
Annegreet G Veldhuis-Vlug ◽  
Gina N Woods ◽  
Sigurdur Sigurdsson ◽  
Susan K Ewing ◽  
Phuong T Le ◽  
...  
Keyword(s):  
Older Adults ◽  
Bone Marrow ◽  
Body Composition ◽  
Body Fat ◽  
Fat Mass ◽  
Lean Mass ◽  
Mineral Density ◽  
1H Mrs ◽  
Testosterone Levels ◽  
Marrow Adiposity

Abstract Context Follicle stimulating hormone (FSH) concentrations increase during the perimenopausal transition and remain high post menopause. Loss of bone mineral density (BMD) and gain of bone marrow adiposity (BMA) and body fat mass also occur during this time. In mice, blocking the action of FSH increases bone mass and decreases fat mass. Objective To investigate the associations between endogenous FSH levels and BMD, BMA and body composition in older adults, independent of estradiol and testosterone levels. Design, setting and participants Older adults from the AGES-Reykjavik Study, an observational cohort study. Main outcome measures Areal BMD, total body fat, and lean mass were measured with DXA. Lumbar vertebral BMA was measured by 1H-MRS. Volumetric BMD and visceral and subcutaneous adipose tissue (VAT, SAT) areas were measured with QCT. The least squares means procedure was used to determine sex-hormone adjusted associations between quartiles of serum FSH and BMD, BMA, and body composition. Results In women (N=238, mean age 81y), those in the highest FSH quartile, compared with the lowest quartile, had lower adjusted mean spine integral BMD (-8.6%), lower spine compressive strength index (-34.8%), higher BMA (+8.4%), lower weight (-8.4%), lower VAT (-17.6%), lower lean mass (-6.1%), and lower fat mass (-11.9%) (all P &lt; 0.05). In men, FSH level was not associated with any outcome. Conclusions Older postmenopausal women with higher FSH levels have higher BMA, but lower BMD and lower fat and lean mass, independent of estradiol and testosterone levels. Longitudinal studies are needed to better understand the underlying mechanisms.

Treatment of acromegaly has substantial effects on body composition. A long-term follow-up study.

2021 ◽  
Author(s):  
Peter Wolf ◽  
Sylvie Salenave ◽  
Emmanuel Durand ◽  
Jacques Young ◽  
Peter Kamenicky ◽  
...  
Keyword(s):  
Body Composition ◽  
Fat Mass ◽  
Lean Mass ◽  
Individual Therapy ◽  
Sensitivity Index ◽  
Igf I ◽  
The Individual ◽  
The Impact

  Background: Acromegaly is associated with changes in body composition. Long-term changes following acromegaly treatment and the impact of different treatments have been less investigated. Methods: We performed a retrospective study in 201 patients with acromegaly. Body composition was assessed by dual-energy X-ray absorptiometry (DXA). To investigate specific effects of treatment vs ageing, changes in body composition were compared in a group of patients evaluated both at the time of active and controlled disease (A>C; n=31) and in another group of patients evaluated two times while the disease was controlled (C>C; n=32). Results: In the whole cohort, IGF-I correlated with fat (r=-0.369;p<0.001) and lean mass (r=0.383;p<0.001). Patients from A>C and C>C groups were comparable for age, sex, BMI and follow-up duration (p=n.s.). Reduction in IGF-I levels was associated with an increase in fat mass and a decrease in lean mass in the A>C group, which was four and eight times more pronounced compared to the C>C group (fat mass: +39±34 vs +10±15%, p<0.001; lean mass: -8±8 vs -0.2±6%, p<0.001, respectively). Changes in fat mass were negatively associated with IGF-I (r=-0.450; p=0.011) and independent of the individual therapy. The daily dose of pegvisomant correlated with fat mass (r=0.421;p=0.002) and insulin sensitivity index (r=-0.466;p<0.001). Conclusions: Treatment of acromegaly strongly impacts body composition until biochemical disease remission, characterized by an increase in fat mass and a decrease in lean mass. These changes are closely associated with the normalization of IGF-I. Thereafter, body composition changes are similar to what is observed with ageing.

scholarly journals Impact of orange juice consumption on macronutrient and energy intakes and body composition in the US population

2012 ◽  
Vol 15 (12) ◽  
pp. 2220-2227 ◽  
Author(s):  
Ying Wang ◽  
Beate Lloyd ◽  
Meng Yang ◽  
Catherine G Davis ◽  
Sang-Gil Lee ◽  
...  
Keyword(s):  
Body Composition ◽  
Waist Circumference ◽  
Children And Adolescents ◽  
Body Fat ◽  
Orange Juice ◽  
Overweight And Obesity ◽  
Cross Sectional ◽  
Percentage Body Fat ◽  
Significant Difference ◽  
The Us

AbstractObjectiveThe present study evaluated the contribution of 100 % orange juice (OJ) consumption to the intakes of macronutrients and energy and its impact on body composition.DesignA cross-sectional study was conducted. The main exposure was OJ consumption based on two non-consecutive 24 h diet recalls. Macronutrient and energy intakes and body composition parameters were outcome measures. All statistical analyses were carried out using SAS and SUDAAN statistical software packages to allow for multistage sample designs.SettingThe US population and its subgroups.SubjectsThe US population aged ≥4 years (n 13 971) from the National Health and Nutrition Examination Survey 2003–2006, conducted by the National Center for Health Statistics.ResultsIn this US population, OJ consumers had lower BMI and healthier lifestyle behaviours (including lower alcohol consumption and smoking as well as higher exercise level) than non-consumers (P < 0·05). After adjusting for covariates, OJ consumers had higher daily intakes of carbohydrate, total sugar, total fat and energy than non-consumers (P < 0·01). However, these linear trends still remained even after OJ was removed from the food list of items consumed. Adult OJ consumers had lower BMI, waist circumference and percentage body fat than non-consumers (P < 0·01), as well as lower odds ratio for overweight and obesity (P < 0·01). These effects were not seen in children and adolescents, where there was no significant difference in BMI, waist circumference and percentage body fat in OJ consumers compared with non-consumers.ConclusionsOJ consumption was associated with healthier body composition in adults; while there were no significant associations between OJ consumption and body composition in children and adolescents.

scholarly journals A Study on Effect of Sleep Patterns on Body Fat Mass of School Going Children (8-10- Years Old) in Mumbai City

2019 ◽  
pp. 1-8
Author(s):  
Nehal Satra ◽  
Rupali Sengupta
Keyword(s):  
Body Composition ◽  
Body Fat ◽  
Fat Mass ◽  
Body Fat Mass ◽  
Sleep Patterns ◽  
Body Type ◽  
Male And Female ◽  
Significant Difference ◽  
Composition Analyzer ◽  
Mumbai City

Aims: To study the effect of sleep patterns on body fat mass of school going children (8-10-year-old) in Mumbai city. Study Design: Body fat mass was analyzed using Inbody 120 body composition analyzer. Total 388 subjects were selected for the study. Place and Duration of Study: The period required to carry out study was from November 2018 to March 2019. 388 subjects (male and female) participated from public to private schools in Mumbai city for the study. Methodology: Total 388 subjects (male and female) participated from 5 schools ranging from public to private school were selected from Mumbai city, (Maharashtra, India). Inbody 120 body composition analyzer was used to assess body fat for the subjects. SPSS version 20 was used for data analysis. Results: A positive correlation was observed between wakeup timings and body fat mass at p≤0.05 (0.00). However, the habit of snoring showed highly significant difference at p≤0.05 for body fat mass (0.00) and fat free mass (0.00). Conclusion: It was concluded that sleep patterns had a significant impact on body fat mass. Therefore, the sleep timings and wakeup timings need to be observed for the children in their growing age as it may have deep impact on child’s body type.

Body Composition of National Collegiate Athletic Association (NCAA) Division I Female Soccer Athletes through Competitive Seasons

2020 ◽  
Author(s):  
Erica Roelofs ◽  
April Bockin ◽  
Tyler Bosch ◽  
Jonathan Oliver ◽  
Christopher W. Bach ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Fat ◽  
Fat Mass ◽  
Lean Mass ◽  
National Collegiate Athletic Association ◽  
Female Athletes ◽  
Division I ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Total Fat

AbstractThe purpose of this study was to examine body composition of National Collegiate Athletic Association Division I female soccer players by position and season. One hundred seventy-five female athletes were categorized by positions of forward (n=47), midfielder (n=51), defender (n=57), and goalkeeper (n=20). A dual X-ray absorptiometry scan assessed percent body fat, total lean mass, total fat mass, arm and leg lean mass and fat mass, and visceral adipose tissue. Goalkeepers had significantly higher total, arm, and leg lean mass and fat mass compared to all other positions (p<0.05). For seasonal changes, body fat percentage was significantly higher in winter off-season (26.7%) compared to summer off-season (25.7%) and pre-season (25.8%; p<0.01) for all positions. Total and leg lean mass was significantly lower in winter off-season compared to all other seasons, and total lean mass was significantly higher in summer off-season than pre-season (p<0.01). Overall, goalkeepers were significantly different than all other positions. Body fat percentage increased and lean mass decreased in winter off-season indicating potential undesired changes in training and/or nutrition over the break whereas lean mass was the highest in summer off-season potentially reflecting the emphasis on resistance training and increased volume of training.

scholarly journals POS0839 BODY COMPOSITION AND FREQUENCY OF SARCOPENIA IN PATIENTS WITH SYSTEMIC SCLEROSIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 673.2-674
Author(s):  
A. Efremova ◽  
O. Nikitinskaya ◽  
N. Toroptsova ◽  
O. Dobrovolskaya ◽  
N. Demin
Keyword(s):  
Body Composition ◽  
Systemic Sclerosis ◽  
Muscle Strength ◽  
Body Fat ◽  
Fat Mass ◽  
Lean Mass ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Chair Stand ◽  
Stand Test

Background:Sarcopenia can be age associated (primary form) or secondary to chronic disorders, including rheumatic inflammatory disorders. Systemic sclerosis (SSc) is a chronic autoimmune rheumatic disease characterized by widespread vasculopathy, progressive fibrosis of the skin and other internal organs, such as lung, kidneys, gastrointestinal tract, cardiovascular system. Different from the other chronic rheumatic inflammatory disorders, sarcopenia has not been well evaluated in SSc patients.Objectives:To assess the body composition (BC) and to identify the frequency of sarcopenia (SP) in SSc patients.Methods:A total of 44 women who met the ACR/EULAR 2013 classification criteria were included. Mean age was 53,2 + 8,8 years. The median disease duration was 7,0 [4,0;12,0] years. 26 (59,1%) patients had limited and 18 (40,9%) - diffuse cutaneous subtype. Body composition was measured using Dual-energy X-ray absorptiometry (DXA) of whole body. The appendicular lean mass index (ALMI) was calculated as the ratio of appendicular lean mass (ALM) to height (kg/m2). Handgrip measurement and chair stand test were performed. Physical function was measured with the Short Physical Performance Battery (SPPB). SP was diagnosed in agreement with the 2019 revised consensus on definition and diagnosis of SP of the European Working Group on Sarcopenia in Older People 2 (EWGSOP2): handgrip <16kg, chair stand test > 15 seconds for 5 rises, ALM <15 kg or ALMI <5.5 kg/m2. Severe SP was detected if the patient additionally had gait speed ≤0.8 m/s or SPPB ≤ 8-point score. Overfat was defined as body fat percentage >35%.Results:The median bone mineral content was 2.0 [1.8; 2.2] kg, total lean mass - 39,5 [35,7; 45,5] kg, ALM - 16,3 [14,5;19,4] kg, ALMI – 6,5 [5,7; 7,2] kg/m2, trunk fat mass – 13,5 [9,1; 16,7] kg and total fat mass - 26,6 [20,1; 34,5] kg. Body fat percentage was 38,8% [34,2; 42,7].9 (20,5%) women had low ALM and low ALMI, 6 (13,6%) – only low ALM. Healthy BC was found in 5 (11,3%), low ALM or low ALMI – in 7 (15,9%), overfat – in 24 (54,5%), low ALM + overfat – in 8 (18,2%) patients. We found no differences in BC between SSc patients with limited and diffuse cutaneous subtype.Low muscle strength (SP probable) was found in 21 (47,7%) women, meanwhile confirmed SP (low muscle strength and muscle mass) was diagnosed in 10 (22,7%) patients, among them 5 (11,4%) persons had severe SP. No significant difference in SP frequency among patients with limited and diffuse cutaneous SSc 4 (15,4%) and 6 (33,3%), respectively, (p=0,27). Osteoporosis was found in 6 (60%) patients with SP without differences in SSc subtypes.Conclusion:Healthy BC was found only in 11,3% cases, while overfat - in 72,7% and low ALM – in 34,1% SSc patients. SP was detected in 22.7% of women, among them in half of cases - severe SP, without any differences between the limited and diffuse subtypes of the disease.Disclosure of Interests:None declared

scholarly journals AB0795 DYNAMIC CHANGES IN QUANTITATIVE INDICES OF BODY COMPOSITION BY DUAL-ENERGY X-RAY ABSORPTIOMETRY IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS ON DIFFERENT THERAPEUTIC REGIMENS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1422.2-1422
Author(s):  
Y. Gorbunova ◽  
T. Popkova ◽  
T. Panafidina ◽  
N. Demin ◽  
E. Nasonov ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Combination Therapy ◽  
Body Fat ◽  
Fat Mass ◽  
Lean Mass ◽  
Dual Energy ◽  
X Ray ◽  
Lean Muscle Mass ◽  
Group I

Background:A redistribution of body fat (abdominal obesity) is quite common in RA patients. Such parameters as body mass index (BMI) and waist circumference do not distinguish or quantify fat and lean (muscle) mass. For that purpose, dual-energy X-ray absorptiometry (DXA) is usually used.Objectives:to compare quantitative body composition in patients with early RA at baseline and after 24 weeks of therapy with different regimens.Methods:The study included 37pts (31 women /6 men) with early RA (ACR/EULAR criteria, 2010), 57 [46.5, 62,0] years old, naïve to treatment with glucocorticoids and disease-modifying anti-rheumatics (DMARDs). Pts were seropositive for IgM RF (76%) and anti-CCP (92%), with highly active RA (DAS28 5,5 [5,1; 6,0]; SDAI 32,4 [22,4; 42], CDAI 29,0 [19,7; 39,5]) scores, and median disease duration of 6.0 [5,5;15.5] months. Methotrexate (MTX) 10 [10-15] mg/week subcutaneously was initiated in all included patients as first line therapy for 12 weeks. By this time point therapy was reviewed in 19 patients (51%) due to MTX inefficacy and adalimumab (ADA) at 40 mg once every 2 weeks was added on top of MTX. DXA scan (HOLOGIC, USA) was used to measure body composition at baseline and after 6mths of treatment with the protocol assessing total body, body fat and lean muscle mass.Results:Based on therapeutic regimens at week 24 all study subjects were divided into 2 groups: Group I (n=18) receiving MTX monotherapy, Group II (n=19) – the combination of MTX and ADA (Table 1). Group I patients had lower body weight, lean and fat mass vs patients from Group II (62 kg vs. 73.7 kg; 40.6 kg vs. 49.7 kg; 21.0 kg vs. 25.8 kg, respectively (p<0.05 in all cases) at baseline. 24 weeks of combination therapy eventuated in body weight gain (73.7 kg vs. 75.8 kg), accumulation of fat (25.8 kg vs. 28.1 kg) and unchanged lean tissue mass. In contrast, patients on MTX monotherapy managed to increase their lean mass (40.6 kg vs. 41.6 kg) without gaining in total fat mass.Table 1.IndicesI group (n=18),monotherapy МТII group (n=19),combination therapy (MTX, ADA)baseline24 weeksΔ,%baseline24 weeksΔ,%Body fat mass, kg21,0 [17,2;26,2]**23,4 [17,5;29,7]+1125,8 [18,4;35,0]28,1 [21,4;37,9]*+9Lean mass, kg40,6 [37,3;44,7]**41,6 [38,2;46,4]***/*+2,549,7 [39,0;56,1]49,9 [41,0;57,6]0,4Total mass, kg62,0 [57,7;77,6]**64,1 [59,5;81,6]***+3,473,7 [64,5;97,9]75,8 [66,8;102,1]*+2,8*p<0,05 reliability of differences in parameters before treatment and after 6mth (Wilcoxon); **p<0.05 differences in baseline values in groups I and II (Mann-Whitney test);***p<0.05 difference in the indices between the groups by the 6mth of therapy; Δ,% difference in indices between the groups by the 6mth of therapy.Conclusion:In general, RA patients on treatment tend to gain weight by week 24. Patients who failed on MTX monotherapy by week 24 and were switched to combination therapy had higher fat mass at baseline. Mediations used for RA treatment produce multidirectional effects on quantitative parameters of body composition: MTX monotherapy triggers some increase of lean mass, while combination of MTX and bDMARD results in weight gain and increase of total and fat mass. These data need to be confirmed in large-scale studies with longer follow-up period.Disclosure of Interests:None declared

scholarly journals The significance of the FTO gene on weight gain and body composition in young Swedish women with severe anorexia nervosa: a three-year follow-up study

2020 ◽  
Author(s):  
Anna Svedlund(New Corresponding Author) ◽  
Bojan Tubic ◽  
Anders Elfvin(Former Corresponding Author) ◽  
Per Magnusson ◽  
Diana Swolin-Eide
Keyword(s):  
Body Composition ◽  
Anorexia Nervosa ◽  
Fat Mass ◽  
Lean Mass ◽  
Quantitative Computed Tomography ◽  
Peripheral Quantitative Computed Tomography ◽  
Nutrition Therapy ◽  
High Energy ◽  
Muscle Area

Abstract Background: The aim of this prospective study was to investigate the potential influence of the fat mass and obesity-associated gene (FTO), SNP rs9939609, on body mass index (BMI) and body composition in women with severe anorexia nervosa during intensive nutrition therapy and after three years. Methods: Twenty-five female anorexia nervosa patients (age 20.1±2.3 years, BMI 15.5±1.0 kg/m2) were treated for 12 weeks with a high-energy diet. FTO was genotyped and body composition parameters were assessed by dual-energy X-ray absorptiometry and peripheral quantitative computed tomography at baseline, after 12 weeks and at three-year follow-up. Results: Patients gained, on average, 9.9 kg and BMI increased to 19.0±0.9 kg/m2 during intensive nutrition therapy. Fat mass increased, p<0.001, but total lean mass was stable. After three years, BMI remained stable, 19.4±3.3 kg/m2, as well as fat mass parameters and total lean mass. Muscle density decreased while the quotient fat/muscle area increased during nutrition therapy, but both then stabilized and remained stable after three years. There were no associations between FTO genotype and BMI or body composition parameters during the nutrition therapy or after three years. A tendency towards more stable BMI was observed in patients with the TT genotype and wider range in BMI for patients with the risk allele A after three years. Conclusions: Irrespective of the FTO genotype, there was no difference in weight response during nutrition therapy, or at three-year follow-up. Hence, there is limited support for individualized therapy for anorexia nervosa based on FTO genotype. Trial registration: Current Controlled Trials ISRCTN76310580. Date of registration: 15/01/2020. Retrospectively registered.

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