scholarly journals The effect of dietaryn-3 fatty acids on serum concentrations of C-reactive protein: a dose–response study

2003 ◽  
Vol 89 (4) ◽  
pp. 517-522 ◽  
Author(s):  
Trine Madsen ◽  
Jeppe H. Christensen ◽  
Mogens Blom ◽  
Erik B. Schmidt
Keyword(s):  
Fatty Acids ◽  
Protein A ◽  
Low Grade ◽  
Serum Concentrations ◽  
Sensitive Assay ◽  
C Reactive Protein ◽  
Double Blind ◽  
Reactive Protein ◽  
Highly Sensitive ◽  
Serum Crp

C-reactive protein (CRP) is a sensitive marker for low-grade inflammation. Long-chainn-3 polyunsaturated fatty acids (PUFA) have anti-inflammatory effects. The objective of the present study was to investigate the effect on serum levels of CRP ofn-3 PUFA at two different doses. We also investigated correlations between CRP and the cellular contents of PUFA. Sixty healthy volunteers (twenty-five women and thirty-five men) were randomly assigned to three treatment groups in a double-blind design. The subjects received a supplement of either 6·6 gn-3 PUFA/d, 2·0 gn-3 PUFA/d or placebo (olive oil) for 12 weeks. CRP was measured using a highly sensitive assay. The median serum CRP concentration was 0·78 mg/l. No significant correlations were found between CRP and the content ofn-3 PUFA in granulocytes or platelets. Subjects receivingn-3 PUFA had a significant (P<0·01) increase in the cellular contents of 20: 5n-3, 22: 5n-3 and 22: 6n-3, with the largest increase occurring in the group receiving 6·6 g PUFA/d. A significant (P<0·01) decrease in cellular content of 18: 2n-6 and 20: 4n-6 was observed simultaneously. Serum CRP concentrations, however, were unaffected by the PUFA-containing supplements. The present study shows that dietary supplementation with PUFA-containing supplements has no effect on serum concentrations of CRP, measured with a highly sensitive assay, in healthy subjects.

C-reactive protein: a marker or a player?

2007 ◽  
Vol 113 (2) ◽  
pp. 79-81 ◽  
Author(s):  
Thomas Nyström
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Events ◽  
Protein A ◽  
Low Grade ◽  
Phase Reaction ◽  
Clinical Markers ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

It has been suggested that Type 2 diabetes may, in part, be precipitated or accelerated by an acute-phase reaction as part of the innate immune response, in which large amounts of cytokines are released from adipose tissue, creating a low-grade inflammatory milieu. There is also firm evidence that atherosclerosis is an immune-mediated inflammatory disease. Therefore it is reasonable to imply that low-grade inflammation is an important pathogenetic factor in atherosclerosis and cardiovascular events in patients with Type 2 diabetes. Over the last few years, there have been a lot of promising clinical markers proposed to link inflammation and atherosclerosis. Of these markers, hs-CRP (high-sensitivity C-reactive protein) might be a prognostic marker for further cardiovascular events, although this has been refuted recently. In this issue of Clinical Science, Castoldi and co-workers have demonstrated that, in patients with Type 2 diabetes categorized into low (<1.0 mg/l), medium (1.0–3.0 mg/l) and high (>3.0 mg/l) hs-CRP groups, serum levels of hs-CRP correlated with lipopolysaccharide-stimulated release of interleukin-1β and interleukin-6 in whole blood. This finding may indicate that low-grade inflammatory activity might influence cytokine production in these patients.

scholarly journals Adiponectin and highly sensitive C-reactive protein levels in obese children aged 9 to 15 years

2011 ◽  
Vol 51 (1) ◽  
pp. 7
Author(s):  
Frecilia Regina ◽  
Kristellina Tirtamulia ◽  
Sarah Maria Warouw
Keyword(s):  
Metabolic Syndrome ◽  
Obese Group ◽  
Controlled Study ◽  
Low Grade ◽  
Obese Children ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Highly Sensitive ◽  
Inflammatory State ◽  
The Mean

Background Childhood obesity is a widespread and growing problem associated with health problems such as metabolic syndrome, diabetes mellitus and cardiovascular disease. A low􀁗grade chronic inflammatory state, reflected by decreased adiponectin and increased highly sensitive C􀁗reactive  protein (hsCRP) levels, may play a role in metabolic syndrome associated with obesity.Objective To assess and compare adiponectin and hsCRP levels in obese and nonnal weight children.Methods We conducted a cross-sectional, case􀁗controlled study in Manado from May to July 2010. Subjects were selected from obese, but otherwise healthy children aged 9-15 years. Control subjects were schoolmates 'With normal body mass index (BMI). We perfonned physical examinations, measured blood pressure, weight and height, and calculated BMI for all subjects. After an overnight fast, all subjects were tested for fasting blood glucose, adiponectin and hsCRP levels.Results The mean adiponectin level in the obese group was 3.6 μg/mL (SD 1.43), lower than that of the normoweight group, 4.8 μg/mL (SD 1.67) (P<0.0001). The mean hsCRP level in the obese group was 3.3 mg/L (SD 3.62) while that of the normoweight group was 0.8 mg/L (SD 1.39) (P<0.0001). There was no inverse correlation between adiponectin and hsCRP levels in obese group (r= 0.048; P= 0.362).Conclusions Lower adiponectin and higher hsCRP levels in the obese group is consistent 'With a low-grade chronic inflammatory state. Other factors that influence adiponecrin and hsCRP production or inflammatory pathways of other adipokines need further evaluation. Early intervention is needed to reduce body weight in obese children.

scholarly journals Serum Calprotectin and Chemerin Concentrations as Markers of Low-Grade Inflammation in Prepubertal Children with Obesity

2020 ◽  
Vol 17 (20) ◽  
pp. 7575 ◽  
Author(s):  
Grażyna Rowicka ◽  
Hanna Dyląg ◽  
Magdalena Chełchowska ◽  
Halina Weker ◽  
Jadwiga Ambroszkiewicz
Keyword(s):  
Low Grade ◽  
Serum Concentrations ◽  
C Reactive Protein ◽  
Prepubertal Children ◽  
Reactive Protein ◽  
Study Population ◽  
Normal Body Weight ◽  
Wbc Count ◽  
Low Grade Inflammation

In adults, obesity is associated with chronic low-grade inflammation, which may cause long-term adverse health consequences. We evaluated whether obesity in prepubertal children also generates this kind of inflammation and whether calprotectin and chemerin may be useful markers for early detection of such inflammation in this group of children. The study population included 83 children aged 2 to 10 years; 62 with obesity and without components of metabolic syndrome and 21 healthy controls with normal body weight. White blood cell (WBC) count, concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), calprotectin, and chemerin were determined in peripheral blood. Our study showed that in the group with obesity, serum concentrations of calprotectin and chemerin, as well as CRP were significantly higher as compared with the controls. We found a significant positive correlation between serum chemerin concentrations and BMI z-score (r = 0.33, p < 0.01) in children with obesity. Chemerin concentration was also positively correlated with CRP level (r = 0.36, p < 0.01) in the whole group of children. These findings suggest that obesity may generate chronic low-grade inflammation as early as in the prepubertal period which can be indicated by significantly higher serum concentrations of calprotectin and chemerin. Calprotectin and especially chemerin seem to be promising indicators of this type of inflammation in children with obesity, but the correlation between these markers requires further research.

scholarly journals P544 Point-of-care finger prick test for C-reactive protein, infliximab and adalimumab serum concentrations

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S514-S515
Author(s):  
A Volkers ◽  
M Löwenberg ◽  
K Bray ◽  
B Bahur ◽  
M Braad ◽  
...  
Keyword(s):  
Point Of Care ◽  
Serum Concentrations ◽  
C Reactive Protein ◽  
Prick Test ◽  
Reactive Protein ◽  
Drug Concentrations ◽  
Deming Regression ◽  
Finger Prick ◽  
Point Of Care Tests ◽  
Serum Crp

Abstract Background Point-of-Care tests (POCTs) allow instant measurement of inflammatory markers and/or drug concentrations. However, currently available POCTs for infliximab (IFX) and adalimumab (ADL) serum concentrations are time consuming. Recently, a new POCT device (ProciseDx, San Diego, CA, USA) was developed which conveniently measures C-reactive protein (CRP), IFX and ADL capillary concentrations within minutes. We aimed to validate this device by comparing POCT results with conventional laboratory tests for serum CRP, IFX and ADL in patients with inflammatory bowel disease (IBD). Methods IBD patients requiring routine measurement of serum CRP, IFX or ADL were invited to participate. Along with serum collection, 20μl of capillary blood was obtained via finger prick and dispensed in a cartridge with a buffer, and placed in the POCT device providing results within two to four minutes. Forty patients were needed to validate the CRP POCT, as this assay was already previously validated in a different population. For the IFX and ADL assays, 120 patients using IFX or ADL were required to validate the POCT. Agreement between the laboratory serum assay and POCT was visualized on a scatter diagram and a Bland-Altman plot. Deming regression was calculated to demonstrate agreement. In addition, Pearson’s correlation coefficient was calculated. Results Until now, 41 patients have been enrolled for the CRP assay, 120 patients for the IFX and 46 patients for the ADL assay. Two ADL patients were sampled twice (n=48). Significant correlations were found for CRP, IFX and ADL (r=0.98, r=0.88 and r=0.86 respectively, Fig. 1). Deming regression analysis of the CRP assay resulted in a slope of 0.71 (95% CI 0.49 to 0.93) and 1.5 (95% CI -0.44 to 3.50) for the intercept. For the IFX assay, the slope was 1.1 (95% CI 0.83 to 1.3) and the intercept was 1.4 (95% CI -0.47 to 3.4). For the ADL assay, the slope was 0.97 (95% CI 0.64 to 1.3) and the intercept was 2.3 (95% CI -0.64 to 5.2). Conclusion A novel POCT using a finger prick approach provides a rapid, user friendly and reliable measurement of CRP, IFX and ADL concentrations within minutes. The capillary CRP was slightly lower than the venous serum CRP, which was consistently observed and considered clinically irrelevant in this cohort.

scholarly journals Role and Usefulness of C-reactive Protein in Women with Polycystic Ovarian Syndrome

2021 ◽  
pp. 64-72
Author(s):  
Indra Prasad Adhikari ◽  
Shreya Nigoskar ◽  
Amresh Kumar Singh ◽  
Arun Mishra
Keyword(s):  
Biochemical Parameters ◽  
Medical Condition ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Low Grade ◽  
C Reactive Protein ◽  
College Hospital ◽  
Medical College ◽  
Reactive Protein ◽  
Serum Crp

Background: Polycystic ovary syndrome (PCOS) is a complex medical condition characterized by elevated androgen levels, menstrual irregularities, and small cysts on one or both ovaries. The prevalence of PCOS is 6 to 10% in women. C-reactive protein (CRP) is an acute-phase protein produced by the hepatic cells and it’s levels increased in inflammation that increases interleukin-6 by macrophages and T cells. Aims and Objective: A correlative study of role and usefulness of CRP in women with PCOS and its correlation with different biochemical parameters. Materials and Methods: This was hospital based case-control study carried out among PCOS was conducted in the Department of Obstetrics & Gynaecology, Index Medical College Hospital, Indore. This study was conducted from 1st January 2018 to 31st December 2019. A total of 260 subjects with age group between 15 to 45 years were divided into two group; cases (130) and controls (130). Results: Among a total of 260 cases, based on clinical and different biochemical parameters, 130 were diagnosis with PCOS and 130 were apparently healthy women. The mean ±SD of various parameters among PCOS cases were; body mass index (BMI) 32.97±8.466, P (<0.001) total cholesterol (TC) 188.42±31.126, P (<0.001), triglyceride (TG) 134.43±50.01, P (<0.001), high density lipoprotein (HDL) 36.29±9.55 TC/HDL ratio, 5.54±1.865 serum CRP, 3.41±0.94 versus BMI 22.87±2.470, P (<0.001), TC155.42±26.333, TG 110.00±42.19, HDL 41.22±10.912, TC/HDL ratio 4.08±1.39, serum CRP 2.25±0.83 P (<0.001) in healthy control. Conclusion: In this study, the role of inflammation and different biochemical markers were studied among PCOS. It was found that a majority of PCOS patients were obese, having insulin resistance. The levels of CRP as a marker of chronic low grade inflammation were higher in newly diagnosed PCOS as compared to the controls. The CRP values correlated well (statistically significant) with increased in BMI and age.

scholarly journals Serum C-Reactive Protein Concentration and Measures of Adiposity in Patients With Type 2 Diabetes Mellitus

2007 ◽  
Vol 7 (4) ◽  
pp. 322-327 ◽  
Author(s):  
Asija Začiragić ◽  
Jasminko Huskić ◽  
Almira Hadžović-Džuvo ◽  
Amina Valjevac ◽  
Nesina Avdagić ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Concentration ◽  
Control Group ◽  
Low Grade ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Serum Crp

We investigated serum concentration of C-reactive protein (CRP) and measures of adiposity in 30 patients with type 2 diabetes mellitus (15 male, 15 female) and 30 age and sex-matched apparently healthy subjects.CRP concentration was determined by laser nephelometry (BN II Analyzer) and CardioPhase high-sensitivity CRP (DADE BEHRING) was used as reagent which consists of polystyrene particles coated with mouse monoclonal antibodies to CRP.Results have shown that serum CRP concentration in patients with type 2 diabetes mellitus was statistically significantly higher compared to control group of healthy subjects (p<0,05). Body mass index (BMI) correlated significantly with serum concentration of CRP in patients with type 2 diabetes mellitus (r=0,614; p<0,001). Statistically significant positive correlation was also found between waist to hip ratio and serum CRP concentration in patients with type 2 diabetes mellitus (r=0,426; p<0,05).Elevated serum CRP concentration in patients with type 2 diabetes mellitus is probably caused by the presence of chronic low-grade inflammation in these patients. It is possible that determined increase of CRP concentration reflects activation of innate immune system components in patients with type 2 diabetes mellitus. Implications of established association between measures of adiposity and serum CRP level in type 2 diabetes mellitus remain unclear.

Chronic Ongoing Stressors and C-Reactive Protein: A Within-Person Study

2019 ◽  
Vol 32 (7-8) ◽  
pp. 892-903 ◽  
Author(s):  
Aniruddha Das
Keyword(s):  
Fixed Effects ◽  
Protein A ◽  
Population Based ◽  
Low Grade ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Social ◽  
Chronic Stressors ◽  
And Gender ◽  
Gender Specific

Objectives: Literature suggests C-reactive protein (CRP)—as a marker of low-grade systemic inflammation—may mediate the linkage between chronic stressors and cardiometabolic conditions. Previous population-based reports are based on weak methodologies and may have yielded incorrect inferences. The current study examined linkages of within-person CRP variation with corresponding variation in stressor burdens. Method: Data were from the 2006, 2010, and 2014 waves of the U.S. Health and Retirement Study. Analysis was through unit fixed effects and first-difference estimators. Both gender-combined and gender-specific models were run. Results: In none of the analyses was CRP positively associated with chronic stressors. This was true among both genders, and in models of linear as well as nonlinear change. Results held in a series of separate robustness checks. Discussion: CRP may not mediate the social etiology of degenerative diseases. Population representative evidence of inflammation’s role in these processes remains absent.

scholarly journals A Study on Highly Sensitive C-Reactive Protein (Hs-CRP) in Patients with Bronchial Asthma

2018 ◽  
Vol 6 (2) ◽  
pp. 62-67
Author(s):  
Md Haroon Ur Rashid ◽  
Md Rezaul Karim Chowdhury ◽  
Md Ehsanul Huq ◽  
Shamimur Rahman ◽  
Nelson Taposh Mondal
Keyword(s):  
Bronchial Asthma ◽  
Systemic Inflammation ◽  
Specific Marker ◽  
Low Grade ◽  
C Reactive Protein ◽  
Asthmatic Patients ◽  
Reactive Protein ◽  
Control Subjects ◽  
Highly Sensitive ◽  
Hs Crp

Background: Asthma is a chronic inflammatory disorder of the airways. Relevance of highly sensitive C-reactive protein (hs-CRP), an acute phase reactant and a sensitive marker of low-grade systemic inflammation in bronchial asthma has not been fully studied.Objectives: Reported studies have found an inverse relationship between lung function and markers of systemic inflammation. The aim of this study was to clarify the relationship between serum level of hs-CRP and bronchial asthma.Materials and method: In this study, hs-CRP was measured in 60 patients with asthma and 40 healthy control subjects. Of all asthmatics, 39 patients had partially controlled and uncontrolled asthma and 21 patients had asthma during exacerbation.Results: Highly sensitive CRP was significantly higher (p<0.000) in asthmatic patients as compared to the control group. In asthmatics with exacerbation, serum hs-CRP was significantly higher than in partially controlled and uncontrolled asthmatic patients (p<0.006) and control subjects (p<0.0001).Conclusion: Serum hs-CRP may be a non specific marker of asthma and its exacerbation.Delta Med Col J. Jan 2018 6(2): 62-67

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