scholarly journals Investigating the role of natural phyto-oestrogens on bone health in postmenopausal women

2003 ◽  
Vol 89 (S1) ◽  
pp. S87-S99 ◽  
Author(s):  
Silvia Valtueña ◽  
Kevin Cashman ◽  
Simon P. Robins ◽  
Aedin Cassidy ◽  
Alwine Kardinaal ◽  
...  
Keyword(s):  
Decision Making ◽  
Clinical Trials ◽  
Bone Loss ◽  
Postmenopausal Women ◽  
Bone Health ◽  
Early Stage ◽  
Daily Intake ◽  
Present Knowledge ◽  
Selection Of

Research on the bone effects of natural phyto-oestrogens after menopause is at a relatively early stage. Published studies are few, difficult to compare and often inconclusive, due in part to design weaknesses. Currently, many questions remain to be answered including to what extent a safe daily intake may prevent postmenopausal bone loss. These questions can only be addressed by conducting well-planned, randomised clinical trials that take into consideration present knowledge in the oestrogen, phyto-oestrogen and bone fields. This review is intended to provide hints for critical decision-making about the selection of subjects, type of intervention, suitable outcome measures and variables that need to be controlled.

scholarly journals Treatment selection of early stage non-small cell lung cancer: the role of the patient in clinical decision making

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
S. Mokhles ◽  
J. J. M. E. Nuyttens ◽  
M. de Mol ◽  
J. G. J. V. Aerts ◽  
A. P. W. M. Maat ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Decision Making ◽  
Small Cell Lung Cancer ◽  
Clinical Decision Making ◽  
Early Stage ◽  
Clinical Decision ◽  
Small Cell ◽  
Small Cell Lung ◽  
Selection Of

SISTEM PENDUKUNG KEPUTUSAN PEMILIHAN GURU BERPRESTASI KOTA MEDAN MENERAPKAN METODE PREFERENCES SELECTION INDEX (STUDI KASUS : DINAS PENDIDIKAN KOTA MEDAN)

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Fajar Syahputra ◽  
Mesran Mesran ◽  
Ikhwan Lubis ◽  
Agus Perdana Windarto
Keyword(s):  
Decision Making ◽  
Decision Support ◽  
Decision Support System ◽  
Support System ◽  
Formal Education ◽  
Basic Education ◽  
Selection Index ◽  
Main Task ◽  
Selection Of

The teacher is a major milestone in the world of education, the ability and achievement of students cannot be separated from the role of a teacher in teaching and guiding students. Based on the Law of the Republic of Indonesia No. 14 of 2005 concerning Teachers and Lecturers, in Article 1 explained that teachers are professional educators with the main task of educating, teaching, guiding, directing, training, evaluating, and evaluating students in early childhood education through formal education, basic education and education medium. Whereas in Article 4 of the Act, it is explained that the position of teachers as professionals serves to enhance the dignity and role of teachers as learning agents to function to improve the quality of national education.Decision making is an election process, among various alternatives that aim to meet one or several targets. The decision-making system has 4 phases, namely intelligence, design, choice and implementation. These phases are the basis for decision making, which ends with a recommendation.The Preferences Selection Index (PSI) method is a rarely used decision support system method. This method is a method developed by stevanie and Bhatt (2010) to solve the Multi Criteria Decision Making (MCDM). With the right consideration, this method can be one of the tools to determine policies in decision-making systems, especially the selection of outstanding teachers. Determination of policies taken as a basis for decision making, must use criteria that can be defined clearly and objectively.Keywords: Decision Support System, PSI, Selection of Achieving Teachers

scholarly journals Two Training-Load Paradoxes: Can We Work Harder and Smarter, Can Physical Preparation and Medical Be Teammates?

2017 ◽  
Vol 12 (s2) ◽  
pp. S2-50-S2-54 ◽  
Author(s):  
Tim J. Gabbett ◽  
Rod Whiteley
Keyword(s):  
Decision Making ◽  
Injury Risk ◽  
Early Stage ◽  
Support Staff ◽  
Training Load ◽  
Shared Decision ◽  
The Relationship ◽  
And Training ◽  
Physical Preparation

The authors have observed that in professional sporting organizations the staff responsible for physical preparation and medical care typically practice in relative isolation and display tension as regards their attitudes toward training-load prescription (much more and much less training, respectively). Recent evidence shows that relatively high chronic training loads, when they are appropriately reached, are associated with reduced injury risk and better performance. Understanding this link between performance and training loads removes this tension but requires a better understanding of the relationship between the acute:chronic workload ratio (ACWR) and its association with performance and injury. However, there remain many questions in the area of ACWR, and we are likely at an early stage of our understanding of these parameters and their interrelationships. This opinion paper explores these themes and makes recommendations for improving performance through better synergies in support-staff approaches. Furthermore, aspects of the ACWR that remain to be clarified—the role of shared decision making, risk:benefit estimation, and clearer accountability—are discussed.

scholarly journals Point/counterpoint: early-stage Hodgkin lymphoma and the role of radiation therapy

Hematology ◽  
2012 ◽  
Vol 2012 (1) ◽  
pp. 313-321 ◽  
Author(s):  
Ralph M. Meyer ◽  
Richard T. Hoppe
Keyword(s):  
Clinical Trials ◽  
Radiation Therapy ◽  
Hodgkin Lymphoma ◽  
Early Stage ◽  
Trial Protocol ◽  
Radiation Oncologist ◽  
Limited Stage ◽  
Considerable Debate

Abstract The results of recent clinical trials for the management of limited-stage Hodgkin lymphoma have led to considerable debate, especially regarding the role of radiation therapy. This review highlights those recent trials and provides perspectives regarding their interpretation from a radiation oncologist and a hematologist. The trial protocol is available at http://www.nejm.org/doi/suppl/10.1056/NEJMoa1111961/suppl_file/nejmoa1111961_protocol.pdf.

A State-of-the-Art Critique Review of the Role of Decision-Making Techniques in NDT for Condition Monitoring

2019 ◽  
pp. 222-236
Author(s):  
Ashish Khaira ◽  
Ravi K. Dwivedi
Keyword(s):  
Decision Making ◽  
Condition Monitoring ◽  
Research Work ◽  
Research Papers ◽  
Operating Personnel ◽  
Detailed Review ◽  
Effective Condition ◽  
Year 2000 ◽  
Selection Of

Nondestructive testing (NDT) is a vital tool in maintenance. Each NDT technique has some benefits and hindrances; therefore, the selection is crucial. Generally, the selection of a technique relies on operating personnel experience, and very few research papers shows uses of the decision-making (DM) approach. It was highlighted by various researchers that if a proper DM approach is used, it will save time and increase fault detection reliability. By keeping this fact in mind, this chapter is an attempt to provide a detailed review of research work from the year 2000-2018 that covered the role of DM techniques while making combinations of NDT for effective condition monitoring. It observed from the literature that very few researchers effectively utilized the power of DM tool. The researcher can use the outcome of this work as a beacon and improve it further.

scholarly journals The role of Tai Chi Chuan exercise on osteoporosis prevention and treatment in postmenopausal women

2011 ◽  
Vol 1 (1) ◽  
pp. 10
Author(s):  
Haiyan Chen
Keyword(s):  
Bone Loss ◽  
Postmenopausal Women ◽  
Tai Chi ◽  
Weight Bearing ◽  
Depression And Anxiety ◽  
Osteoporosis Prevention ◽  
Mineral Density ◽  
Cross Sectional ◽  
Tai Chi Chuan

Osteoporosis is a disease characterized by fragile bones and high susceptibility to low trauma fractures. Tai Chi, an ancient Chinese mind-body exercise that is reported to enhance muscle function, balance and flexibility, and to reduce pain, depression and anxiety, may safely and effectively be used to prevent or treat osteoporosis. The aim of this review is to evaluate the evidence for Tai Chi as an intervention to reduce rate of bone loss in postmenopausal women. A literature search on randomized controlled trials (RCTs), prospective cohort studies, and cross-sectional studies that included Tai Chi as an intervention, and had at least 1 outcome related to measurement of bone metabolism were identified in PubMed/Medline. Twenty-one controlled studies were identified in the database, which suggested Tai Chi slowed down the loss of bone mineral density in most postmenopausal women, improved balance and strength, relieves pain from arthritis, and improved mental strength so they can cope better with chronic diseases. Regular Tai Chi Chuan exercise is beneficial for retarding bone loss in the weight-bearing bones of postmenopausal women.

scholarly journals Hedgehog Inhibitors Suppress Osteoclastogenesis in In Vitro Cultures, and Deletion of Smo in Macrophage/Osteoclast Lineage Prevents Age-Related Bone Loss

2020 ◽  
Vol 21 (8) ◽  
pp. 2745
Author(s):  
Yukihiro Kohara ◽  
Ryuma Haraguchi ◽  
Riko Kitazawa ◽  
Yuuki Imai ◽  
Sohei Kitazawa
Keyword(s):  
Bone Resorption ◽  
Bone Loss ◽  
Signaling Pathway ◽  
Early Stage ◽  
Osteoclast Differentiation ◽  
Osteoclast Formation ◽  
Age Related ◽  
Hh Signaling

The functional role of the Hedgehog (Hh)-signaling pathway has been widely investigated in bone physiology/development. Previous studies have, however, focused primarily on Hh functions in bone formation, while its roles in bone resorption have not been fully elucidated. Here, we found that cyclopamine (smoothened (Smo) inhibitor), GANT-58 (GLI1 inhibitor), or GANT-61 (GLI1/2 inhibitor) significantly inhibited RANKL-induced osteoclast differentiation of bone marrow-derived macrophages. Although the inhibitory effects were exerted by cyclopamine or GANT-61 treatment during 0–48 h (early stage of osteoclast differentiation) or 48–96 h (late stage of osteoclast differentiation) after RANKL stimulation, GANT-58 suppressed osteoclast formation only during the early stage. These results suggest that the Smo-GLI1/2 axis mediates the whole process of osteoclastogenesis and that GLI1 activation is requisite only during early cellular events of osteoclastogenesis. Additionally, macrophage/osteoclast-specific deletion of Smo in mice was found to attenuate the aging phenotype characterized by trabecular low bone mass, suggesting that blockage of the Hh-signaling pathway in the osteoclast lineage plays a protective role against age-related bone loss. Our findings reveal a specific role of the Hh-signaling pathway in bone resorption and highlight that its inhibitors show potential as therapeutic agents that block osteoclast formation in the treatment of senile osteoporosis.

scholarly journals An Evaluation Model of Quantitative and Qualitative Fuzzy Multi-Criteria Decision-Making Approach for Location Selection of Transshipment Ports

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Ji-Feng Ding ◽  
Chien-Chang Chou
Keyword(s):  
Decision Making ◽  
Distance Measure ◽  
Evaluation Model ◽  
Multi Criteria Decision Making ◽  
Location Selection ◽  
Container Logistics ◽  
Proposed Model ◽  
Fuzzy Mcdm ◽  
Selection Of

The role of container logistics centre as home bases for merchandise transportation has become increasingly important. The container carriers need to select a suitable centre location of transshipment port to meet the requirements of container shipping logistics. In the light of this, the main purpose of this paper is to develop a fuzzy multi-criteria decision-making (MCDM) model to evaluate the best selection of transshipment ports for container carriers. At first, some concepts and methods used to develop the proposed model are briefly introduced. The performance values of quantitative and qualitative subcriteria are discussed to evaluate the fuzzy ratings. Then, the ideal and anti-ideal concepts and the modified distance measure method are used in the proposed model. Finally, a step-by-step example is illustrated to study the computational process of the quantitative and qualitative fuzzy MCDM model. The proposed approach has successfully accomplished our goal. In addition, the proposed fuzzy MCDM model can be empirically employed to select the best location of transshipment port for container carriers in the future study.

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