scholarly journals Energy metabolism of young rats after early postnatal overnutrition

2002 ◽  
Vol 88 (3) ◽  
pp. 301-306 ◽  
Author(s):  
Petra Wiedmer ◽  
Sylvia Ortmann ◽  
Susanne Klaus
Keyword(s):  
Energy Metabolism ◽  
Energy Expenditure ◽  
Body Fat ◽  
Later Life ◽  
Daily Energy Intake ◽  
Daily Energy ◽  
Total Daily Energy Expenditure ◽  
Ad Libitum ◽  
Total Fat ◽  
The Relationship

Early postnatal overnutrition (PNO) induced by restricting litter size in rats leads to increased body-weight (BW) and body-fat gain in later life. PNO rats are used as an animal model of moderate obesity and early hyperinsulinism. We investigated whether the increased adiposity could be due to a decreased energy expenditure. Male newborn Wistar rats were raised in litters of either two (SL) or twelve pups (NL), weaned at 4 weeks of age and subsequently fed ad libitum. BW was recorded continuously until 12 weeks of age. Daily energy intake, total daily energy expenditure (EE, measured by indirect calorimetry) and body composition were measured in weaned pups at 5, 8 and 12 weeks of age. SL rats displayed increased BW compared with NL rats from week 2 to 5 and again from week 10 to 12. Lean body mass, body fat and protein content and total EE were increased in SL rats at week 5. The same linear correlation described the relationship between BW and total EE in NL and SL rats. At week 8 to 12 no differences in energy metabolism could be found, but the total fat content was increased in SL rats at week 12. Energy balance, i.e. assimilated energy minus EE, was no different between SL and NL at any time that it was measured. We conclude that although PNO rats display increased adiposity in early life, there seem to be no long-lasting effects on energy metabolism in later life, even if a tendency to increased adiposity can still be detected.

Application of the Doubly Labeled Water Technique for Studying Total Energy Expenditure in Young Children: A Review

1994 ◽  
Vol 6 (1) ◽  
pp. 11-30 ◽  
Author(s):  
Michael I. Goran
Keyword(s):  
Energy Metabolism ◽  
Energy Expenditure ◽  
Young Children ◽  
Human Subjects ◽  
Resting Energy Expenditure ◽  
Whole Body ◽  
Doubly Labeled Water ◽  
Daily Energy ◽  
Total Daily Energy Expenditure ◽  
Body Energy

The doubly labeled water technique represents an unobtrusive and noninvasive means to measure total daily energy expenditure in free-living human subjects who are unaware that energy expenditure is being measured. When combined with measurement of resting energy expenditure, the doubly labeled water technique can also be used to estimate energy expenditure related to physical activity. The relatively recent availability of the doubly labeled water technique in humans has led to several advances in the fundamental understanding of whole body energy metabolism in several important areas. The purpose of this paper is to review the areas in which the doubly labeled water technique has specifically advanced our understanding of whole-body energy metabolism in young children.

scholarly journals Does Increased Exercise or Physical Activity Alter Ad-Libitum Daily Energy Intake or Macronutrient Composition in Healthy Adults? A Systematic Review

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e83498 ◽  
Author(s):  
Joseph E. Donnelly ◽  
Stephen D. Herrmann ◽  
Kate Lambourne ◽  
Amanda N. Szabo ◽  
Jeffery J. Honas ◽  
...  
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Energy Intake ◽  
Healthy Adults ◽  
Daily Energy Intake ◽  
Macronutrient Composition ◽  
Daily Energy ◽  
Ad Libitum

scholarly journals Leptin Responsiveness in Chronically Decerebrate Rats

Endocrinology ◽  
2007 ◽  
Vol 148 (10) ◽  
pp. 4623-4633 ◽  
Author(s):  
Ruth B. S. Harris ◽  
Timothy J. Bartness ◽  
Harvey J. Grill
Keyword(s):  
Energy Expenditure ◽  
Body Fat ◽  
Serum Testosterone ◽  
Control Group ◽  
Energy Status ◽  
Lower Serum ◽  
Peripheral Tissues ◽  
Leptin Receptors ◽  
Ad Libitum ◽  
Ad Libitum Intake

Peripheral infusions of physiological doses of leptin decrease body fat mass, but it is not known whether this results from direct effects on peripheral tissue or activation of central leptin receptors. In this study, we infused chronically decerebrate (CD) rats, in which the forebrain was surgically isolated from the caudal brainstem, with 60 μg leptin/d or PBS for 14 d from ip mini-osmotic pumps. The CD rats were tube fed an amount of food equivalent to the intake of ad libitum-fed intact controls or 75% of this amount to account for their reduced energy expenditure. Control rats fed ad libitum or tube fed 75, 100, or 125% of their ad libitum intake also were peripherally infused with leptin or PBS. CD rats had a lower serum testosterone, energy expenditure, and lean body mass compared with controls but had increased levels of adiponectin and leptin and were obese. Leptin increased body fat and decreased energy expenditure during the light period in 100%-fed CD rats, but not 75%-fed CD rats. Leptin decreased body fat of ad libitum- and 100%-fed but not 75%-fed or 125%-fed intact controls. Energy expenditure did not change in any control group. These results show that leptin can change body fat independent of a change in food intake or energy expenditure, that the forebrain normally prevents leptin from inhibiting energy expenditure through mechanisms initiated in the caudal brainstem or peripheral tissues, and that the leptin response in both intact and CD rats is determined by the energy status of the animal.

scholarly journals Impact of high energy oral nutritional supplements consumed in the late afternoon on appetite, energy intake and cardio-metabolic risk factors in females with lower BMI

2021 ◽  
Author(s):  
Sadia Fatima ◽  
Konstantinos Gerasimidis ◽  
Charlotte Wright ◽  
Dalia Malkova
Keyword(s):  
Insulin Sensitivity ◽  
Energy Expenditure ◽  
Energy Intake ◽  
Nutritional Supplement ◽  
High Energy ◽  
Fasting Insulin ◽  
Daily Energy Intake ◽  
Late Afternoon ◽  
Oral Nutritional Supplements ◽  
Daily Energy

Abstract Background/Objective Morning consumption of a single dose of high-energy oral nutritional supplement (ONS) in females with a lower BMI displaces some of the food eaten at breakfast but increases overall daily energy intake. This study investigated the effectiveness of ONS intake in the late afternoon and for longer duration. Subjects/Methods Twenty-one healthy females (mean ± SD, age 25 ± 5 years; BMI 18.7 ± 1.2 kg/m2) participated in a randomised, crossover study with two experimental trials. In the afternoon of days 1–5, participants consumed either ONS (2.510 MJ) or low-energy PLACEBO drink (0.377 MJ) and recorded food eaten at home. On day six, energy intake was measured during buffet meals, and energy expenditure, appetite measurements and blood samples were collected throughout the day. Result Over the 5-day period, in the ONS trial energy intake from evening meals was lower (ONS, 2.7 ± 0.25 MJ; Placebo, 3.6 ± 0.25 MJ, P = 0.01) but averaged total daily energy intake was higher (ONS, 9.2 ± 0.3 MJ; PLACEBO, 8.2 ± 0.4 MJ, P = 0.03). On day six, energy intake, appetite scores, plasma GLP-1 and PYY, and energy expenditure were not significantly different between the two trials but fasting insulin concentration and HOMAIR, were higher (P < 0.05) and insulin sensitivity score based on fasting insulin and TAG lower (P < 0.05) in ONS trial. Conclusion Late afternoon consumption of ONS for five consecutive days by females with a lower BMI has only a partial and short-lived energy intake suppression and thus increases daily energy intake but reduces insulin sensitivity.

Regulatory alterations of daily energy expenditure induced by fasting or overfeeding in unrestrained rats

1987 ◽  
Vol 63 (2) ◽  
pp. 465-470 ◽  
Author(s):  
H. Shibata ◽  
L. J. Bukowiecki
Keyword(s):  
Energy Expenditure ◽  
Energy Intake ◽  
Normal Values ◽  
Sucrose Solution ◽  
Normal Diet ◽  
The Other ◽  
O2 Consumption ◽  
Daily Energy Expenditure ◽  
Daily Energy ◽  
Ad Libitum

The consequences of fasting or overfeeding during 2 days on energy expenditure were investigated by continuously monitoring O2 consumption in unrestrained, unanesthetized rats. O2 consumption decreased by 15% on the 1st day of fasting and then by an additional 15% on the 2nd day. On the 3rd day, when rats were fed again, energy intake increased by 30% above control (prefasting) values, whereas energy expenditure rapidly increased but no more than control values. On the other hand, when ad libitum fed animals were offered a sucrose solution (32%) for 2 days, energy intake increased by 30% and energy expenditure by 9–12%. On the 3rd day, when the rats were fed with their normal diet, energy intake significantly decreased under control (preoverfeeding) values during one day, but energy expenditure rapidly returned to normal values. The results show that fasting decreases, whereas hyperphagia increases 24-h energy expenditure during the treatments. When the treatments are terminated, energy expenditure rapidly returns to normal values, but fasting induces a postfasting increase of energy intake (during 2 days), whereas hyperphagia, on the contrary, results in a transient decrease of appetite. This indicates that alterations of food intake induce compensatory changes of energy expenditure during the treatments, but that after the treatments, energy balance is normalized via regulatory adjustments in the ratio of energy expenditure over energy intake.

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