scholarly journals Prevalence and haemopoietic effects of low serum vitamin B12levels in geriatric medical patients

1997 ◽  
Vol 78 (1) ◽  
pp. 57-63 ◽  
Author(s):  
David J. Stott ◽  
Peter Langhorne ◽  
Anne Hendry ◽  
Pamela J Mckay ◽  
Tessa Holyoake ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Blood Count ◽  
Serum Vitamin ◽  
Full Blood Count ◽  
Control Group ◽  
Vitamin B ◽  
Medical Patients ◽  
Medical Unit ◽  
Count Change ◽  
Low Serum

The clinical significance of low serum vitamin B12levels in elderly people is controversial. We aimed to document the prevalence of a low serum vitamin B12(<175pmol/l) in patients referred to a geriatric medical unit, and to determine whether haemopoiesis is commonly affected in elderly patients with low serum vitamin B12. We studied prospectively 472 consecutive referrals to a geriatric medical unit; fifty-six (13%) had a low serum vitamin B12level, of whom nineteen (34%) of the fifty-six also had evidence of Fe deficiency (serum ferritin<45ng/ml). Low vitamin B12was associated with a raised mean erythrocyte volume (MCV; mean 96·0 (SD 6·7) fl), compared with a control group (91·7 (SD 6·0) fl; P=0·001). However, only thirteen (23%) of the fifty-six patients with a low vitamin Blz had an MCV≥100 fl. Mean haemoglobin (Hb) levels were not significantly reduced in those with a low vitamin B12. In a subsequent study the haematological response to intramuscular hydroxocobalamin was examined in thirty-four patients with a low serum vitamin B12. Treatment resulted in a significant fall in MCV and rise in Hb; these effects could be detected both in those patients with an initially normal full blood count (change in MCV -1·2 (SD 1·2); Hb + 0·5 (SD 0·6); P<0·01) and in those with macrocytosis and/or anaemia (-9·1 (SD 11·8); + 0·8 (SD 1·2); P<0·05). A low serum vitamin B12is common in geriatric medical patients. This is usually associated with an upset in erythropoiesis, although the abnormalities are often subtle and may not be apparent on inspection of the full blood count. Elderly patients with serum vitamin B12<175pmol/l should be assumed to have vitamin deficiency even if their full blood count is normal.

scholarly journals Low serum vitamin B12 levels are associated with degenerative rotator cuff tear

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Jae Hwa Kim ◽  
Go-Tak Kim ◽  
Siyeoung Yoon ◽  
Hyun Il Lee ◽  
Kyung Rae Ko ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Rotator Cuff ◽  
Univariate Analysis ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Control Group ◽  
Mineral Density ◽  
Calcium Phosphorus ◽  
Healthy Control ◽  
Low Serum

Abstract Background Vitamin B12 (Vit B12) deficiency results in elevated homocysteine levels and interference with collagen cross-linking, which may affect tendon integrity. The purpose of this study was to investigate whether serum Vit B12 levels were correlated with degenerative rotator cuff (RC) tear. Methods Eighty-seven consecutive patients with or without degenerative RC tear were enrolled as study participants. Possible risk factors (age, sex, medical history, bone mineral density, and serum chemistries including glucose, magnesium, calcium, phosphorus, zinc, homocysteine, Vitamin D, Vit B12, homocysteine, and folate) were assessed. Significant variables were selected based on the results of univariate analyses, and a logistic regression model (backward elimination) was constructed to predict the presence of degenerative RC tear. Results In the univariate analysis, the group of patients with degenerative RC tear had a mean concentration of 528.4 pg/mL Vit B12, which was significantly lower than the healthy control group (627.1 pg/mL). Logistic regression analysis using Vit B12 as an independent variable revealed that Vit B12 concentrations were significantly correlated with degenerative RC tear (p = 0.044). However, Vit B12 levels were not associated with tear size. Conclusion Low serum levels of Vit B12 were independently related to degenerative RC tear. Further investigations are warranted to determine if Vit B12 supplementation can decrease the risk of this condition.

scholarly journals Low Serum Vitamin B-12 Concentrations Are Prevalent in a Cohort of Pregnant Canadian Women

2016 ◽  
Vol 146 (5) ◽  
pp. 1035-1042 ◽  
Author(s):  
Carly E Visentin ◽  
Shannon P Masih ◽  
Lesley Plumptre ◽  
Theresa H Schroder ◽  
Kyoung-Jin Sohn ◽  
...  
Keyword(s):  
Serum Vitamin ◽  
Vitamin B ◽  
Vitamin B 12 ◽  
Low Serum

scholarly journals Haematological Presentations in Acute and Chronic Tramadol Intoxication

2020 ◽  
Vol 5 (1) ◽  
pp. 26-36
Author(s):  
Loveday U. Zebedee ◽  
◽  
Owubokiri N. Jeremiah ◽  
Anthony E. Soroh ◽  
Eni-yimini S. Agoro ◽  
...  
Keyword(s):  
Treatment Group ◽  
Normal Saline ◽  
Blood Count ◽  
Saline Solution ◽  
Lethal Dose ◽  
Haemoglobin Concentration ◽  
Chronic Phase ◽  
Male Rats ◽  
Full Blood Count ◽  
Control Group

Introduction Tramadol is a synthetic centrally acting analgesic used worldwide for pain relief, but now abused as a euphoria generating substance. The short- and long-term implications of tramadol intoxication on blood cells and its components are still hazy and controversial. Aim Our primary aim was to evaluate the alterative pattern of haematological parameters resulting from acute or chronic tramadol intoxication. Method The study was made of acute and chronic phases of sixty male rats (Rattusnorvegicus) randomly pair-divided into established groups of six male rats each. The acute stage consisted of a control group of 6 rats administered with normal saline solution, and a treatment group of 6 rats administered with lethal dose of tramadol. The control group for the chronic stage consisted of 6 rats that were administered normal saline solution. Whereas, the tramadol-dependent groups comprised of 3 groups of 6 rats each administered orally with 50 mg/kg, 100 mg/kg, and 200 mg/kg of tramadol for 90 days respectively. Statistical analyses consisted of the one-way analysis of variance (ANOVA), Student’s t-test, and Pearson’s Correlation using the JMP statistical discovery™ software version 14.1. Blood samples were collected after anesthetic sacrifice by cardiac puncture for the analysis of full blood count and red cell indices using SYSMEX Automated Blood Count machine (SYSMEX KX-21N ANALYZER) and microscopy for blood film reading. Results Results of the acute phase of the study showed that the packed cell volume (PCV) in the treatment group (51.00±2.96%) was significantly higher (t=3.99, p=0.002) than control (37.83±1.43%). Similarly, the haemoglobin concentration (Hb) in the treatment group (14.70±0.46 g/dL) was significantly higher (t=5.10, p=0.005) than control (11.55±0.41 g/dL). The mean cell haemoglobin concentration (MCHC) was significantly lower (t=2.67, p=0.02) in the control group (28.30±0.52 g/dL) than treatment (30.43±0.61 g/dL). However, that of the chronic phase exhibited a progressive increase in platelet count which was proportional to increasing dosage of treatment (t=8.59, p=0.007). Conclusion This study has demonstrated that tramadol administration could cause haematological alterations which could be beneficial if administrated optimally and deleterious, if abused. Therefore, indiscriminate and prolonged use of tramadol should be monitored to avert haemotoxicity.

Low vitamin B12 level and vitamin D level adversely affect on cochlear health in women

2020 ◽  
Vol 90 (3-4) ◽  
pp. 333-338
Author(s):  
Isil Karaer ◽  
Yahya Akalın
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Otoacoustic Emissions ◽  
Serum Vitamin ◽  
Vitamin B ◽  
Cochlear Function ◽  
Distortion Product ◽  
Vitamin D Levels ◽  
Study Participants ◽  
Low Serum

Abstract. The aim of this study is to examine the association between low serum vitamin B12 levels and low serum vitamin D levels and cochlear health in women. A prospective case–control study was carried out in the Department of Otolaryngology, Malatya Training and Research Hospital between 2017–2018. Thirty (30) patients with vitamin B12 deficiency (a mean age of 32.5 ± 1.7 years(y) women); 30 patients with vitamin D deficiency (a mean age of 32.3 ± 1.58 y women) and 30 controls (a mean age of 27.8 ± 1.48 y women) were recruited. The study participants have no evidence of symptomatic hearing loss. Transiently evoked otoacoustic emissions (TEOAEs) and distortion product otoacoustic emissions (DPOAEs) of the study participants were recorded. A comparative analysis of the parameters revealed that results at TEOAE 1,2,3,4 kHz (p = 0.013, p = 0.002, p = 0.001, p = 0.001, respectively) and at DPOAE 1, 2, 6 kHz ( p < 0.001, p < 0.001, p = 0.002, respectively) were somewhat lower in patients with vitamin B12 deficient group when compared with the controls. Moreover, TEOAE 3,4 kHz (p = 0.005, p = 0.013 respectively) and DPOAE 1,2,6 kHz (p = 0.005, p = 0.01, p = 0.031, respectively) were lower in the vitamin D deficiency group compared with the controls. There was a significant association between both vitamin B12 deficiency and vitamin D deficiency and cochlear health. Patients with vitamin B12 and vitamin D deficiency should be evaluated for cochlear function.

scholarly journals Maternal vitamin A status in intrauterine growth retarded babies

2017 ◽  
Vol 8 (3) ◽  
pp. 30-34 ◽  
Author(s):  
Alakh Ram Verma ◽  
Prafulla Kumar Khodiar ◽  
Debapriya Rath ◽  
Seema Dhurandhar ◽  
Pradeep Kumar Patra
Keyword(s):  
Birth Weight ◽  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Serum Vitamin ◽  
Maternal Serum ◽  
Control Group ◽  
Study Group ◽  
Intrauterine Growth ◽  
Vitamin A Status ◽  
Low Serum

Background: Beside calorie and protein consumption micronutrients like folic acid, vitamin D and vitamin A have been postulated to play major role in intrauterine growth of neonates. Vitamin A compounds are critical for vision, reproduction, embryonic development, immune function and regulation of cell proliferation and differentiation.Aims and Objectives: To determine the relationship of maternal serum vitamin A levels with birth weight of babies.Material and Methods: Study group consisted of 58 randomly selected mothers who delivered at term small for gestational age babies (birth weight less than 2.5kg.). The control group comprises of 52 matched mothers, who delivered normal babies. Biochemical estimation of serum vitamin A was done by HPLC method using sigma reagent of all subjects.Results: Significantly high (p<0.05) number of mothers in study group had low serum vitamin A level compared to mothers in control group. There was a linear relationship between vitamin A status and mean birth weight of the babies.Conclusion: Although the low serum vitamin A level of mothers was significantly associated with intrauterine growth retardation, the exact effect of a vitamin A deficiency on the birth weight of babies remain unclear, but the finding suggests the importance of adequate vitamin A supplementation to pregnant mothers in India.Asian Journal of Medical Sciences Vol.8(3) 2017 30-34

scholarly journals Effect of Annickia polycarpa (Stten and Mass.) Annonaceae, leaf extract on chemo-suppression of hyperparasitemia, body weight, hematological indices and survivor time of Plasmodium berghei infested mice in the Peter’s test

2019 ◽  
Author(s):  
Frederick Ayertey ◽  
Emmanuel Kofi Kumatia ◽  
Godfrey Kyaakyile Bagyour ◽  
Kenneth Opare Asare ◽  
Valantine Chi Mbatchou ◽  
...  
Keyword(s):  
Body Weight ◽  
Survival Time ◽  
Blood Count ◽  
White Blood Cells ◽  
Negative Control ◽  
Full Blood Count ◽  
Control Group ◽  
Hematological Indices ◽  
Mean Survival Time ◽  
Dose Dependent

Abstract Background: Malaria is an infectious disease that is spread through the bite of female anopheles mosquito resulting in the death of hundreds of thousands of people per year. Medicinal plants provide crude extracts and purified compounds for malaria treatment. Annickia polycarpa is one of such plants whose bark is used for this purpose. However, the antimalaria effect of its leaf is not known. We hereby report the investigation of antimalaria effect of A. polycarpa leaf. Methods: Antimalaria effect of the ethanol extract of A. polycarpa leaf (APLE) was investigated in P. berghei infested ICR mice in the Peter’s test. The effect of the extract on development and chemo-suppression of hyperparasitemia, reduction in body weight and mean survival time were evaluated. Full blood count analysis on the infected mice were performed to determine the effect of treatment with APLE on hematological indices such as red and white blood cells and platelets. Acute toxicity and phytochemical tests of the extract were also performed. Results: APLE administered orally at 50, 200 and 400 mg/kg produced profound dose-dependent chemo-suppressive effect of 89.37 – 95.50 % of P. berghei after 4 consecutive days of treatment which compares with 86.22 % obtained for Quinine 30 mg/kg i.m. under the same regimen. APLE also protected the mice against reduction in body weight associated with malaria which was P < 0.05 at 50 mg/kg. Furthermore, APLE promoted dose-dependent mean survival time in the Kaplan-Meier curve. Only 25.0 % of mice in the negative control group survived after 30 days compared to 100 % survival for mice in APLE 400 mg/kg and Quinine 30 mg/kg groups. The results from the full blood count shows that APLE caused (P < 0.05) dose dependent increase in RBC, HGB, HCT, WBCs, lymphocytes and platelets. The LD50 of APLE was above 5000 mg/kg p.o. Conclusions: APLE showed profound antimalaria effect with very high margin of safety. Hematological alterations that resulted from treatment of with APLE indicate significant improvement in general health and safe recovery from the parasitic attack. These findings show that the leaf of A. polycarpa can also be used to treat malaria.

scholarly journals Association between the Level of Serum Vitamin B12 and Venous Thromboembolism in African American Population

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 4957-4957
Author(s):  
Ratesh Khillan ◽  
Nyein Htway Yu ◽  
Haoxu Ouyang ◽  
Mohan Preet
Keyword(s):  
Cohort Study ◽  
Venous Thromboembolism ◽  
Elderly Patients ◽  
Vitamin B12 ◽  
Cancer Patients ◽  
Orthopedic Surgery ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Control Group ◽  
Chi Square

Background Multiple risk factors have been linked to venous thromboembolism (VTE). It is well established that elevated level of homocysteine correlated with increased risk of VTE. Some studies showed that vitamin B12 deficiency may be the cause for homocysteinemia. Therefore, it is recommended by some groups that vitamin B12 should be supplemented in the patient with high homocysteine to prevent VTE. However, more recent study has shown that there is correlation between the high serum Vitamin B12 level and risk of VTE in cancer patients.[1] provoked VTE after orthopedic surgery was also shown to be associated with elevated vitamin B12 serum levels in elderly patients. The role of vitamin B12 in VTE patients is not fully understood. Our study is to see whether there is correlation between serum Vitamin B12 level and risk of VTE in general population. Methods 177 Patients admitted to Kingsbrook Jewish Medical Center between January 1st, 2015 to December 31st, 2018 with the diagnosis of VTE were identified. 95 cases had measured serum Vitamin B12 results within 3 months. 97 patients without any history of VTE who were seen in the hematology clinic during the same period time were used as control in this study. Demographic information and Vitamin B12 level were collected. T test and chi-square were used for statistical analysis. Results VTE patients had a median age of 70, which is significantly higher than the median age of 57 in the control group. The mean level of vitamin B12 in control group was 620 pg/mL, which was lower than the average vitamin B12 level (770 pg/mL, p=0.0344) in the VTE group. When we divided the patients into 3 groups based on Vitamin B12 level: Low B12 (<250 pg/mL), Moderate B12 (250-800 pg/mL) and High B12 (>800 pg/mL). We observed 41% of VTE patients have B12 level more than 800 pg/mL while only 20% of control patients have high B12 level (chi-square, p=0.006). Discussion Our study showed that vitamin B12 level is significantly elevated in patients diagnosed with VTE and more than 40% of those patients actually have vitamin b12 level more than 800 pg/mL. It is known that elevated vitamin B12 level is associated with inflammation and increased mortality.[2] An association between elevated B12 levels and cancer has been reported in several studies [3]. It is unclear elevated vitamin B12 levels predict undiagnosed cancer which is a known risk factor for VTE or vitamin B12 directly contribute hypercoagulation. Nevertheless, we should be cautious when supplementing vitamin B12 and the dosage may need to be titrated closely. More clinical studies are definitely warranted. References 1. Arendt JFH, el al. Elevated plasma vitamin B12 levels and risk of venous thromboembolism among cancer patients: A population-based cohort study. PubMed ID: 26724465 2. Grossfeld A1, et al. Symptomatic venous thromboembolism in elderly patients following major orthopedic surgery of the lower limb is associated with elevated vitamin B12 serum levels. PubMed ID:23000313 3. Johan F.H. Arendt, Henrik T. Sørensen, Laura J. Horsfall and Irene Petersen. Elevated Vitamin B12 Levels and Cancer Risk in UK Primary Care: A THIN Database Cohort Study. EPI-17-1136 Published April 2019 Disclosures No relevant conflicts of interest to declare.

Effects of a Nutritional Supplement Fortified with Vitamin B-12 on Well Nourished, Free-Living Elderly Subjects

2006 ◽  
Vol 76 (2) ◽  
pp. 95-99 ◽  
Author(s):  
Sandra Hirsch ◽  
Laura Leiva ◽  
Pía de la Maza ◽  
Vivian Gattás ◽  
Gladys Barrera ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Serum Vitamin ◽  
The Elderly ◽  
Nutritional Supplement ◽  
Elderly Subjects ◽  
Control Group ◽  
Vitamin B ◽  
Free Living ◽  
Healthy Elderly ◽  
Vitamin B 12

Vitamin B-12 deficiency is prevalent among the elderly population but it is often unrecognized because the clinical manifestations are not present. Objective: To evaluate the effects of a nutritional supplement fortified with vitamin B-12 on well nourished, free-living elderly subjects. Patients and methods: Healthy elderly subjects attending two of four clinics were allocated to receive, over six months’ duration, a nutritional supplement with 3.8 µg of vitamin B-12. Subjects attending the other two clinics served as controls. Serum vitamin B-12 levels were measured at baseline and 6 months after the supplementation was started. Results: After 6 months of consuming the supplement fortified with vitamin B-12, serum B-12 concentration increased from 350.1 ± 166.5 pmol/L to 409.0 ± 166.1 and decreased in the control group from 319.4 ± 129.1 to 290.1 ± 135.7 (ANOVA, p < 0.005). Conclusion: A supplementation with 3.8 µg /day of vitamin B-12 led to significant improvements in the serum concentrations of vitamin B-12 in older persons.

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