scholarly journals Dynamics of conjunctival impression cytologic changes after vitamin A supplementation

1997 ◽  
Vol 77 (6) ◽  
pp. 863-869 ◽  
Author(s):  
Swapan Chowdhury ◽  
N. K. Ganguly ◽  
Minni Verma ◽  
Rajesh Kumar ◽  
Lata Kumar ◽  
...  
Keyword(s):  
Vitamin A ◽  
Oral Dose ◽  
Controlled Study ◽  
Impression Cytology ◽  
Double Blind ◽  
Vitamin A Supplementation ◽  
Double Blind Placebo ◽  
Future Studies ◽  
Plasma Retinol ◽  
Retinol Concentration

AbstractTo investigate the chronological changes in conjunctival epithelium after supplementation with a massive oral dose of vitamin A, conjunctival impression cytology (CIC) with transfer was carried out repeatedly among 200 children aged 6–120 months in a randomized, double-blind, placebo-controlled study in Chandigarh (India). Significant conversion to normal CIC started 71–80 d after vitamin A supplementation and by 101–110d conversion had taken place in all children. Compared with the placebo group, plasma retinol concentration at 100d post-supplement was found to be significantly higher in the vitamin A-supplemented group P = 0·04. This study demonstrates that CIC responds to a massive oral dose of vitamin A 3–4 months after supplementation. These findings should guide future studies and evaluations in which CIC is used to assess response to vitamin A interventions.

scholarly journals Effect of neonatal vitamin A supplementation on mortality in infants in Tanzania (Neovita): a randomised, double-blind, placebo-controlled trial

The Lancet ◽  
2015 ◽  
Vol 385 (9975) ◽  
pp. 1324-1332 ◽  
Author(s):  
Honorati Masanja ◽  
Emily R Smith ◽  
Alfa Muhihi ◽  
Christina Briegleb ◽  
Salum Mshamu ◽  
...  
Keyword(s):  
Vitamin A ◽  
Controlled Trial ◽  
Double Blind ◽  
Vitamin A Supplementation ◽  
Double Blind Placebo

Treatment of spasticity with repetitive magnetic stimulation; a double-blind placebo-controlled study

1996 ◽  
Vol 2 (5) ◽  
pp. 227-232 ◽  
Author(s):  
Jorgen F Nielsen ◽  
Thomas Sinkjaer ◽  
Johannes Jakobsen
Keyword(s):  
Multiple Sclerosis ◽  
Stretch Reflex ◽  
Magnetic Stimulation ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Future Studies ◽  
Sham Stimulation ◽  
Repetitive Magnetic Stimulation ◽  
Reflex Threshold

The effect of repetitive magnetic stimulation on spasticity was evaluated in 38 patients with multiple sclerosis in a double-blind placebo-controlled study. One group was treated with repetitive magnetic stimulation (n=2l) and the other group with sham stimulation (n=l7). Both groups were seated twice daily for 7 consecutive days. Primary end-points of the study were changes in the patients self-score, in clinical spasticity score, and in the stretch reflex threshold. The self-score of ease of daily day activities improved by 22% (P=0.007) after treatment and by 29% (P=0.004) after sham stimulation. The clinical spasticity score improved 3.3±4.7 arbitrary unit (AU) in treated patients and 0.7±2.5 AU in sham stimulation (P-0.003). The stretch reflex threshold increased 4.3±7.5 degls in treated patients and-3.8±9.7 degls in sham stimulation (P=0.001). The data presented in this study supports the idea that repetitive magnetic stimulation has an antispastic effect in multiple sclerosis. Future studies should darify the optimal treatment regimen.

Effect of early neonatal vitamin A supplementation on mortality during infancy in Ghana (Neovita): a randomised, double-blind, placebo-controlled trial

The Lancet ◽  
2015 ◽  
Vol 385 (9975) ◽  
pp. 1315-1323 ◽  
Author(s):  
Karen M Edmond ◽  
Sam Newton ◽  
Caitlin Shannon ◽  
Maureen O'Leary ◽  
Lisa Hurt ◽  
...  
Keyword(s):  
Vitamin A ◽  
Controlled Trial ◽  
Double Blind ◽  
Vitamin A Supplementation ◽  
Double Blind Placebo
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