scholarly journals Absorption of iron from ferric hydroxypyranone complexes

1994 ◽  
Vol 71 (2) ◽  
pp. 203-207 ◽  
Author(s):  
D. G. Maxton ◽  
R. P. H. Thompson ◽  
R. C. Hider
Keyword(s):  
Normal Subjects ◽  
Whole Body ◽  
Fe Deficiency ◽  
Body Counting ◽  
Whole Body Counting

The absorption of 59Fe from preparations of FeSO4 and the ferric hydroxypyranone complexes maltol and ethyl maltol was studied by whole-body counting in normal subjects and patients with Fe deficiency. Fe in the Fe3+ complexes was in general absorbed almost as well as Fe2+. It is concluded that the absorption of Fe3+ from hydroxypyranone complexes is much greater than that from simple Fe3+ salts; this may prove an efficient and less toxic form of Fe for the treatment of deficiency.

Long-Term Clearance of [57Co]Cyanocobalamin in Vegans and Pernicious Anaemia

1980 ◽  
Vol 58 (1) ◽  
pp. 101-103 ◽  
Author(s):  
S. Amin ◽  
T. Spinks ◽  
A. Ranicar ◽  
M. D. Short ◽  
A. V. Hoffbrand
Keyword(s):  
Intrinsic Factor ◽  
Pernicious Anaemia ◽  
Normal Subjects ◽  
Whole Body ◽  
Least Squares Fit ◽  
Significant Difference ◽  
Maximum Period ◽  
Body Counting ◽  
Whole Body Counting

1. Whole-body counting has been used to monitor the clearance of [57Co]cyanocobalamin in normal subjects, vegans and patients with pernicious anaemia. After oral administration of 57Colabelled cyanocobalamin (1 μg/l μCi), subjects were counted for radioactivity monthly for a maximum period of 1 year. 2. The results obtained were consistent with a monoexponential clearance model and a least-squares fit showed that there was no significant difference between the mean clearance rates for the vegans and normal subjects. 3. The patients with pernicious anaemia cleared the vitamin significantly more quickly than the normal control subjects. 4. This may be due to failure to reabsorb biliary vitamin B12 in pernicious anaemia because of the absence of intrinsic factor.

Studies of Calcium Absorption in Man Using a CD-2 Whole-Body Counter

1977 ◽  
Vol 16 (04) ◽  
pp. 163-167
Author(s):  
K. Bakos ◽  
Věra Wernischová
Keyword(s):  
Calcium Absorption ◽  
Whole Body ◽  
Control Group ◽  
Absorption Process ◽  
Whole Body Counter ◽  
Absorption Studies ◽  
Body Counting ◽  
Calcium Load ◽  
Calcium Malabsorption ◽  
Whole Body Counting

SummaryWhole-body counting makes an important contribution of radioisotope techniques to ȁEin vivo“ absorption studies, in comparison with other methods. In a large number of subjects, the method was tested for its usefulness in the diagnosis of calcium malabsorption. The effects of drugs, of the calcium load in the gut and of the whole-body content of calcium on the absorption process were studied in a control group.

A Modified Chair Geometry for Whole Body Counting

1976 ◽  
Vol 15 (05) ◽  
pp. 246-247
Author(s):  
S. C. Jain ◽  
G. C. Bhola ◽  
A. Nagaratnam ◽  
M. M. Gupta
Keyword(s):  
Marked Improvement ◽  
Point Of View ◽  
Whole Body ◽  
Spatial Response ◽  
Body Counting ◽  
The Subject ◽  
Whole Body Counting ◽  
The Buddha

SummaryIn the Marinelli chair, a geometry widely used in whole body counting, the lower part of the leg is seen quite inefficiently by the detector. The present paper describes an attempt to modify the standard chair geometry to minimise this limitation. The subject sits crossed-legged in the “Buddha Posture” in the standard chair. Studies with humanoid phantoms and a volunteer sitting in the Buddha posture show that this modification brings marked improvement over the Marinelli chair both from the point of view of sensitivity and uniformity of spatial response.

Body potassium by four-pi 40K counting: an anthropometric correction

1984 ◽  
Vol 246 (2) ◽  
pp. F234-F239 ◽  
Author(s):  
R. N. Pierson ◽  
J. Wang ◽  
J. C. Thornton ◽  
T. B. Van Itallie ◽  
E. W. Colt
Keyword(s):  
Adipose Tissue ◽  
Single Crystal ◽  
Covariance Analysis ◽  
Whole Body ◽  
Exchangeable Sodium ◽  
Independent Evidence ◽  
Body Counting ◽  
Whole Body Counting

Four-pi whole body counting for the 1.46 meV photon of 40K has apparent advantages over single-crystal or two-pi counters in efficiency and in subject geometry independence. However, our studies of obese populations have disclosed a systematic undermeasurement of 40K, suggesting that nonhomogeneous K distribution results in systematic undercounting of 40K. In the current study 42K, emitting a 1.52 meV photon, was used in 109 volunteers ranging from 50 to 181 kg, and multiregression covariance analysis was applied to develop correction formulas based on anthropometrics. These corrections quantitatively account for the unappreciated loss of 40K and 42K photons in annular adipose tissue that surrounds the lean body, in which most K+ is concentrated. The correction ranges from 1 to 28% and is a linear (although different) function of weight in both sexes. Thus corrected, body potassium measurements, taken in conjunction with exchangeable sodium and water measurements, provide estimates for whole body osmolality that match measured serum values. Such a quantitative accounting for previously "lost" cation in 58 subjects provides independent evidence for the appropriateness and accuracy of the correction. With this correction, body potassium was recalculated in the 1,492 adult members of a previously reported group of 3,083 subjects.

Whole Body Counting of Vitamin B12 58Co Absorption Supplemented by Profile Scanning

1970 ◽  
Vol 5 (4) ◽  
pp. 261-264
Author(s):  
N. D. C. Finlayson ◽  
J. D. Simpson ◽  
D. J. C. Shearman
Keyword(s):  
Vitamin B12 ◽  
Whole Body ◽  
Body Counting ◽  
Whole Body Counting

scholarly journals Brief Note: A Note Concerning the "100 Per Cent Value" in Iron Absorption Studies by Whole Body Counting

Blood ◽  
1964 ◽  
Vol 23 (6) ◽  
pp. 757-761 ◽  
Author(s):  
LEWIS M. SCHIFFER ◽  
D. C. PRICE ◽  
J. CUTTNER ◽  
S. H. COHN ◽  
EUGENE P. CRONKITE
Keyword(s):  
Iron Absorption ◽  
Whole Body ◽  
Body Counter ◽  
Whole Body Counter ◽  
Absorption Studies ◽  
Body Counting ◽  
Whole Body Counting ◽  
Body Count

Abstract The 4-hour whole body count is found to be clinically valid as a "100 per cent value" in iron absorption studies performed with a whole body counter. Measurement of iron absorption can be made 2 weeks after ingestion of radioiron, but not prior to this period.

scholarly journals The Elution of 51Cr from Labelled Leukocytes —a New Theory

Blood ◽  
1969 ◽  
Vol 33 (3) ◽  
pp. 408-413 ◽  
Author(s):  
PETER M. RONAI
Keyword(s):  
Covalent Bond ◽  
Paper Electrophoresis ◽  
Cellular Protein ◽  
Whole Body ◽  
Trichloracetic Acid ◽  
Protein Fragments ◽  
Body Counting ◽  
Whole Body Counting

Abstract Chromium-51 elutes rapidly from labelled leukocytes and tumor cells both in vitro and in vivo. Eluted 51Cr is dialysable and is not precipitated with trichloracetic acid and it has therefore been assumed to be free chromium which has dissociated from the labelled cellular protein. In vitro studies with 51Cr-labelled albumin have, however, demonstrated the extreme stability of the covalent bond between chromium and protein. Paper electrophoresis experiments are here described which show that the 51Cr which elutes from labelled mouse peritoneal cells behaves electrophoretically like 51Cr-labelled peptides and not at all like free 51Cr in either hexavalent or trivalent forms, or 51Cr-labelled lysine and arginine. Whole body counting studies after the intravenous injection of the various 51Cr preparations into mice indicate that eluted 51Cr and 51Cr-labelled peptides also have similar biologic behavior. Together, the electrophoretic and whole body counting studies exclude the presence of significant amounts of free 51Cr (either hexavalent or trivalent) in the 51Cr that elutes from labelled cells and supports the hypothesis that 51Cr elution results from turnover of labelled protein within the cell and loss of non-reutilisable labelled protein fragments. Confirmation of this theory would provide a powerful technic for the study of intra and extracellular protein metabolism.

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