scholarly journals The effect of pyridoxine deficiency on intestinal absorption of amino acids and peptides in the rat

1972 ◽  
Vol 28 (03) ◽  
pp. 417 ◽  
Author(s):  
A. M. Asatoor ◽  
Amrit K. Chadha ◽  
I. M. P. Dawson ◽  
M. D. Milne ◽  
D. I. Prosser
Keyword(s):  
Amino Acids ◽  
Intestinal Absorption ◽  
Pyridoxine Deficiency

scholarly journals Absorption of ofloxacin isomers in the rat small intestine.

1997 ◽  
Vol 41 (10) ◽  
pp. 2274-2277 ◽  
Author(s):  
L Rabbaa ◽  
S Dautrey ◽  
N Colas-Linhart ◽  
C Carbon ◽  
R Farinotti
Keyword(s):  
Amino Acids ◽  
Intestinal Absorption ◽  
Secretory Pathway ◽  
Saturable Absorption ◽  
Optical Isomers ◽  
Apical Side ◽  
Intestinal Transporter ◽  
Rate Of Absorption ◽  
Ofloxacin Enantiomers

Ofloxacin, a chiral fluoroquinolone, possesses two optical isomers. The antibacterial activity of S-(-)-ofloxacin is 8 to 128 times higher than that of R-(+)-ofloxacin. In the rat, a saturable absorption process has been described for racemic ofloxacin. In the present study we investigated the mechanism underlying the in vivo intestinal absorption of ofloxacin enantiomers in the rat. Blood samples were collected from the portal vein. Our results show that the intestinal absorption of ofloxacin isomers is pH dependent, both enantiomers being best absorbed at neutral pH. S-(-)-Ofloxacin seems to have a greater affinity for the intestinal transporter (initial concentrations at 5 min [C(init)] are 0.17 +/- 0.04 and 0.12 +/- 0.03 microg/ml for S-(-)- and R-(+)-ofloxacin, respectively). Dipeptides fail to modify ofloxacin absorption, but amino acids reduce both isomers' absorption (C(init) is reduced by 53 and 33% with glycine for S-(-)- and R-(+)-ofloxacin, respectively, and by 59 and 42% with L-leucine). Gamma amino butyric acid interferes with the absorption of ofloxacin isomers, but less seriously than do amino acids. Furthermore, ofloxacin competes with other fluoroquinolones or P-glycoprotein substrates for a common secretory pathway, resulting in an increased rate of absorption for both ofloxacin isomers; this is probably an indirect result of their reduced efflux from the apical side of intestinal cells.

INTESTINAL ABSORPTION OF AMINO ACIDS

1960 ◽  
Vol 47 (1) ◽  
pp. 131-138 ◽  
Author(s):  
TADASHI SUGAWA ◽  
HITOSHI AKEDO ◽  
MASAMI SUDA
Keyword(s):  
Amino Acids ◽  
Intestinal Absorption

scholarly journals Intestinal Absorption of Amino Acids and Peptides in Hartnup Disorder

1976 ◽  
Vol 10 (4) ◽  
pp. 246-249 ◽  
Author(s):  
J V Leonard ◽  
T C Marrs ◽  
J M Addison ◽  
D Burston ◽  
K M Clegg ◽  
...  
Keyword(s):  
Amino Acids ◽  
Intestinal Absorption ◽  
Hartnup Disorder

Intestinal Absorption of Amino Acids

1969 ◽  
Vol 22 (3) ◽  
pp. 292-299 ◽  
Author(s):  
RICHARD P. SPENCER
Keyword(s):  
Amino Acids ◽  
Intestinal Absorption

Intestinal Absorption of Dipeptides and Corresponding Free Amino Acids in Hartnup Disease

1970 ◽  
Vol 39 (1) ◽  
pp. 1P-1P ◽  
Author(s):  
A. M. Asatoor ◽  
B. Cheng ◽  
K. D. G. Edwards ◽  
A. F. Lant ◽  
D. M. Matthews ◽  
...  
Keyword(s):  
Amino Acids ◽  
Intestinal Absorption ◽  
Free Amino Acids ◽  
Free Amino
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