scholarly journals Interrelationships between copper deficiency and dietary ascorbic acid in the rabbit

1970 ◽  
Vol 24 (1) ◽  
pp. 61-69 ◽  
Author(s):  
C. E. Hunt ◽  
W. W. Carlton ◽  
P. M. Newberne
Keyword(s):  
Ascorbic Acid ◽  
Cortical Bone ◽  
Cytochrome Oxidase ◽  
Oxidase Activity ◽  
Copper Deficiency ◽  
Acid Supplementation ◽  
Cytochrome Oxidase Activity ◽  
Cu Deficiency ◽  
Calcium And Phosphorus ◽  
Ascorbic Acid Supplementation

1. Copper deficiency was induced in growing rabbits and the effects of ascorbic acid supplementation were studied.2. Signs of Cu deficiency, including reduced growth, achromotrichia and alopecia, anaemia, and gross alterations in the bones of the forelimbs, developed most rapidly in those animals fed ascorbic acid.3. Microscopic lesions in ossification centres were seen only in bones of rabbits which hadm received the vitamin.4. Calcium and phosphorus contents of ash from cortical bone were not changed.5. Compared with the controls, the concentration of liver Cu decreased and that of iron increased (> 50%) in Cu-deficient animals.6. Cytochrome oxidase activity was reduced in liver and heart in Cu-deficient animals; this effect was accentuated in heart preparations from animals fed ascorbic acid.

scholarly journals Copper deficiency in chicks: effects of ascorbic acid on iron, copper, cytochrome oxidase activity, and aortic mucopolysaccharides

1970 ◽  
Vol 24 (3) ◽  
pp. 607-614 ◽  
Author(s):  
C. E. Hunt ◽  
Joanne Landesman ◽  
P. M. Newberne
Keyword(s):  
Ascorbic Acid ◽  
Cytochrome Oxidase ◽  
Oxidase Activity ◽  
Copper Deficiency ◽  
Chondroitin Sulphate ◽  
Aortic Rupture ◽  
Control Diet ◽  
Cytochrome Oxidase Activity ◽  
Cu Deficiency ◽  
Acid Mucopolysaccharides

1. Copper deficiency was induced in newly hatched chicks by feeding on a milk-based diet for 12 d; effects of supplementation with ascorbic acid were studied.2. Cu deficiency alone resulted in 30% mortality from aortic rupture. This was associated with a 20% increase in total acid mucopolysaccharides in the aorta, manifested as an increase in chondroitin sulphate and a relative decrease in hyaluronic acid. Cytochrome oxidase activity of liver and heart was less than half that of the controls.3. Supplementing the Cu-deficient diet with 0.5 % L-ascorbic acid increased mortality to 40%, raised total aortic acid mucopolysaccharides to a higher level, and increased liver iron by 36%.4. Supplementing the control diet with ascorbic acid decreased liver Cu by 30% and significantly reduced total aortic acid mucopolysaccharides.5. The enhancement of the Cu-deficiency effect by ascorbic acid probably results from interactions between ascorbic acid and absorption or metabolism of Cu; untoward effects of supplementing the control diet with ascorbic acid may be interpreted as manifestations of ascorbic acid toxicity per se.

Mitochondria and Cytocrome Oxidase in Copper Deficiency in the Rat

1967 ◽  
Vol 25 ◽  
pp. 164-165
Author(s):  
Joseph R. Goodman ◽  
Peter R. Dallman
Keyword(s):  
Molecular Structure ◽  
Cytochrome Oxidase ◽  
Oxidase Activity ◽  
Wistar Rats ◽  
Copper Deficiency ◽  
Large Decrease ◽  
Deficient Diet ◽  
Cytochrome Oxidase Activity ◽  
Mitochondrial Fractions ◽  
Mitochondrial Cytochromes

Weanling Wistar rats reared on copper deficient diet, in addition to becoming anemic, developed a marked depression of cytochrome oxidase activity in certain tissues. Cytochrome oxidase was determined in homogenates by the method of Cooperstein and Lazarow, and estimated in mitochondrial fractions by means of spectral analysis. Activities of this enzyme in cooper deficient rats, expressed as percent of control concentrations, was 27% for heart muscle and 34% for liver, while other mitochondrial cytochromes were not depressed. This enzyme, which contains copper in its molecular structure is found exclusively in mitochondria. The heart with its large decrease in cytochrome oxidase activity was at the same time hypertrophied and very firm in its consistency.

Cytochrome Oxidase Activity at The Hepatic Parenchyma Different Periods of Ischemia and Obstructive Jaundice

2019 ◽  
Vol 9 (5) ◽  
pp. p8944
Author(s):  
Askarov Tahir Askarovich ◽  
Akhmedov Mirhalil Dzhalilovich ◽  
Fayziev Yokub Nishanovic ◽  
Ashurmetov Ahmadjon Makhamadjonovich ◽  
Dalimov Kenjabek Sabutaevich ◽  
...  
Keyword(s):  
Obstructive Jaundice ◽  
Cytochrome Oxidase ◽  
Oxidase Activity ◽  
Hepatic Parenchyma ◽  
Cytochrome Oxidase Activity

Histochemical assessment of cytochrome oxidase activity for monitoring ischemic muscle injury

1985 ◽  
Vol 88 (2) ◽  
pp. 265-276 ◽  
Author(s):  
Richard M. Millis ◽  
Theodore A. Stephens ◽  
Gerard Harris ◽  
Columbus Anonye ◽  
Michael Reynolds
Keyword(s):  
Cytochrome Oxidase ◽  
Oxidase Activity ◽  
Muscle Injury ◽  
Cytochrome Oxidase Activity ◽  
Ischemic Muscle

Effects of ascorbic acid supplementation on immune status in healthy women following a single bout of exercise

2021 ◽  
Author(s):  
Piyawan Bunpo ◽  
Amonphat Chatarurk ◽  
Kodchaporn Intawong ◽  
Kananek Naosuk ◽  
Phennapha Klangsinsirikul
Keyword(s):  
Ascorbic Acid ◽  
Immune Status ◽  
Acid Supplementation ◽  
Healthy Women ◽  
Single Bout ◽  
Ascorbic Acid Supplementation
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