scholarly journals The blood picture in the guinea-pig in acute and chronic scurvy

1960 ◽  
Vol 14 (3) ◽  
pp. 259-268 ◽  
Author(s):  
B. J. Constable
Keyword(s):  
Guinea Pig ◽  
Blood Picture

scholarly journals Normal Blood Picture of the Guinea Pig

Nature ◽  
1955 ◽  
Vol 176 (4495) ◽  
pp. 1218-1218 ◽  
Author(s):  
D. L. J. BILBEY ◽  
T. NICOL
Keyword(s):  
Guinea Pig ◽  
Normal Blood ◽  
Blood Picture

scholarly journals CERTAIN CHARACTERISTICS OF THE LEUKOCYTES OF GUINEA PIG BLOOD WITH PARTICULAR REFERENCE TO THE KURLOFF BODY

Blood ◽  
1947 ◽  
Vol 2 (Special_Issue_Number_1) ◽  
pp. 125-141 ◽  
Author(s):  
EMILY SMITH
Keyword(s):  
Guinea Pig ◽  
Critical Review ◽  
Blood Cells ◽  
Guinea Pigs ◽  
Review Of The Literature ◽  
Blood Picture ◽  
Mononuclear Leukocyte ◽  
A Cell ◽  
Normal Human ◽  
Special Studies

Abstract A critical review of the literature on the leukocytes of the guinea pig has been presented, with added observations from studies of the blood cells of more than 500 guinea pigs. Special studies of the Kurloff inclusion body were made on these animals to obtain information regarding its origin and significance because this entity occurs in the mononuclear leukocyte, which is a cell of great interest in the pathogenesis of tuberculosis. The normal blood picture of the guinea pig was discussed and summarized in terms of the blood picture of the normal human being.

scholarly journals The effects of age and anaesthetic on the blood picture of the cuts, Galea musteloides

1976 ◽  
Vol 10 (3) ◽  
pp. 279-284
Author(s):  
P. F. Watson ◽  
Christine M. Hawkey
Keyword(s):  
Platelet Count ◽  
Guinea Pig ◽  
Cell Count ◽  
Guinea Pigs ◽  
Mononuclear Cells ◽  
White Cell Count ◽  
Red Cell ◽  
Blood Picture ◽  
Blood Samples ◽  
Cell Parameters

Blood samples from 25 adult and 6 immature cuis were examined. There were slight differences in red cell parameters (RBC, Hb, PCV, MCV, MCH, & MCHC) between cuis and guinea-pigs. The total white cell count of cuis was much lower. The neutrophils of the cuis, as of the guinea-pig, had eosinophilic granules and were therefore termed pseudoeosinophils. Kurloff bodies were not present in mononuclear cells. There were more platelets in cuis blood compared with guinea-pig blood. The choice of anaesthetic did not influence any of the red cell parameters of the cuis, but may have affected the relative numbers of pseudoeosinophils, the platelet count and the percentage of reticulocytes. Immature animals had a lower erythrocyte count, a higher MCH and fewer platelets than adults.

scholarly journals An experimental study of haemolytic disease of the newborn due to isoimmunization of pregnancy. II. Report of an attempt to produce anti-red cell isoantibodies in guinea-pigs, together with a note on the blood picture of one-day-old guinea-pigs

1950 ◽  
Vol 48 (4) ◽  
pp. 458-463 ◽  
Author(s):  
L. S. Mynors ◽  
D. H. Heard ◽  
R. R. A. Coombs
Keyword(s):  
Experimental Study ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Red Cell ◽  
Blood Picture ◽  
Haemolytic Disease ◽  
Small Series

1. Repeated inoculation of thirty-six guinea-pig does with random blood of guinea-pig bucks failed to produce any demonstrable anti-red cell isoantibodies.2. A note is included on the blood picture of a small series of newborn guinea-pigs aged between 12 and 24 hr.

Effect of Contraceptive Steroids on the Endometrium of Guinea Pig: SEM study

1977 ◽  
Vol 35 ◽  
pp. 668-669
Author(s):  
Mai M. Said ◽  
Ramesh K. Nayak ◽  
Randall E. McCoy
Keyword(s):  
Guinea Pig ◽  
Reproductive Tract ◽  
Three Dimensional ◽  
Female Reproductive Tract ◽  
Human Female ◽  
Surface Ultrastructure ◽  
Transmission Electron ◽  
Sem Study ◽  
Uterine Mucosa ◽  
Group 1

Burgos and Wislocki described changes in the mucosa of the guinea pig uterus, cervix and vagina during the estrous cycle investigated by transmission electron microscopy. More recently, Moghissi and Reame reported the effects of progestational agents on the human female reproductive tract. They found drooping and shortening of cilia in norgestrel and norethindrone- treated endometria. To the best of our knowledge, no studies concerning the effects of mestranol and norethindrone given concurrently on the three-dimensional surface features on the uterine mucosa of the guinea pig have been reported. The purpose of this study was to determine the effect of mestranol and norethindrone on surface ultrastructure of guinea pig uterus by SEM.Seventy eight animals were used in this study. They were allocated into two groups. Group 1 (20 animals) was injected intramuscularly 0.1 ml vegetable oil and served as controls.

Ultrastructure and Drug Metabolism in the Developing Guinea Pig

1973 ◽  
Vol 31 ◽  
pp. 538-539
Author(s):  
W. Kuenzig ◽  
M. Boublik ◽  
J.J. Kamm ◽  
J.J. Burns
Keyword(s):  
Guinea Pig ◽  
Metabolic Activity ◽  
Animal Species ◽  
Adult Animal ◽  
Smooth Endoplasmic Reticulum ◽  
Fetal Life ◽  
Mixed Function Oxidase ◽  
Cytochrome P 450 ◽  
Microsomal Mixed Function Oxidase ◽  
Mixed Function Oxidase Activity

Unlike a variety of other animal species, such as the rabbit, mouse or rat, the guinea pig has a relatively long gestation period and is a more fully developed animal at birth. Kuenzig et al. reported that drug metabolic activity which increases very slowly during fetal life, increases rapidly after birth. Hepatocytes of a 3-day old neonate metabolize drugs and reduce cytochrome P-450 at a rate comparable to that observed in the adult animal. Moreover the administration of drugs like phenobarbital to pregnant guinea pigs increases the microsomal mixed function oxidase activity already in the fetus.Drug metabolic activity is, generally, localized within the smooth endoplasmic reticulum (SER) of the hepatocyte.

Glycogen in guinea pig neutrophils: Ultrastructural study of neutrophils at the intradermal site of BCG injection

1983 ◽  
Vol 41 ◽  
pp. 726-727
Author(s):  
Corazon D. Bucana
Keyword(s):  
Bone Marrow ◽  
Guinea Pig ◽  
Electron Density ◽  
Peritoneal Cavity ◽  
Ultrastructural Study ◽  
Guinea Pigs ◽  
Random Distribution ◽  
Glycogen Content ◽  
Polymorphonuclear Neutrophils ◽  
Ultrastructural Studies

In the circulating blood of man and guinea pigs, glycogen occurs primarily in polymorphonuclear neutrophils and platelets. The amount of glycogen in neutrophils increases with time after the cells leave the bone marrow, and the distribution of glycogen in neutrophils changes from an apparently random distribution to large clumps when these cells move out of the circulation to the site of inflammation in the peritoneal cavity. The objective of this study was to further investigate changes in glycogen content and distribution in neutrophils. I chose an intradermal site because it allows study of neutrophils at various stages of extravasation.Initially, osmium ferrocyanide and osmium ferricyanide were used to fix glycogen in the neutrophils for ultrastructural studies. My findings confirmed previous reports that showed that glycogen is well preserved by both these fixatives and that osmium ferricyanide protects glycogen from solubilization by uranyl acetate.I found that osmium ferrocyanide similarly protected glycogen. My studies showed, however, that the electron density of mitochondria and other cytoplasmic organelles was lower in samples fixed with osmium ferrocyanide than in samples fixed with osmium ferricyanide.

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