Retrospective Metaphor Interviews as an additional layer in elicited metaphor investigations

2015 ◽  
pp. 119-138 ◽  
Author(s):  
Sonya L. Armstrong
Keyword(s):  
Additional Layer

scholarly journals A novel box for aerosol and droplet guarding and evacuation in respiratory infection (BADGER) for COVID-19 and future outbreaks

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hau D. Le ◽  
Gordon A. Novak ◽  
Kevin C. Janek ◽  
Jesse Wang ◽  
Khang N. Huynh ◽  
...  
Keyword(s):  
Respiratory Infection ◽  
Healthcare Providers ◽  
Airborne Particles ◽  
Risk Of Infection ◽  
Indirect Contact ◽  
Vacuum Suction ◽  
Qualitative And Quantitative ◽  
Additional Layer ◽  
Increased Risk ◽  
Design Construction

AbstractThe coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected millions and killed more than 1.7 million people worldwide as of December 2020. Healthcare providers are at increased risk of infection when caring for patients with COVID-19. The mechanism of transmission of SARS-CoV-2 is beginning to emerge as airborne spread in addition to direct droplet and indirect contact as main routes of transmission. Here, we report on the design, construction, and testing of the BADGER (Box for Aerosol and Droplet Guarding and Evacuation in Respiratory Infection), an affordable, scalable device that contains droplets and aerosol particles, thus minimizing the risk of infection to healthcare providers. A semi-sealed environment is created inside the BADGER, which is placed over the head of the patient and maintains at least 12-air changes per hour using in-wall vacuum suction. Multiple hand-ports enable healthcare providers to perform essential tasks on a patient’s airway and head. Overall, the BADGER has the potential to contain large droplets and small airborne particles as demonstrated by simulated qualitative and quantitative assessments to provide an additional layer of protection for healthcare providers treating COVID-19 and future respiratory contagions.

scholarly journals A Continuously Active Antimicrobial Surface Coating Reduces Bioburden in a Healthcare Setting

2020 ◽  
Vol 41 (S1) ◽  
pp. s439-s439
Author(s):  
Valerie Beck
Keyword(s):  
Surface Coating ◽  
Geometric Mean ◽  
Healthcare Setting ◽  
Aerobic Bacteria ◽  
Healthcare Settings ◽  
Additional Layer ◽  
Clostridioides Difficile ◽  
Sustained Reduction ◽  
Before And After ◽  
Healthcare Associated

Background: It is well known that contaminated surfaces contribute to the transmission of pathogens in healthcare settings, necessitating the need for antimicrobial strategies beyond routine cleaning with momentary disinfectants. A recent publication demonstrated that application of a novel, continuously active antimicrobial surface coating in ICUs resulted in the reduction of healthcare-associated infections. Objective: We determined the general microbial bioburden and incidence of relevant pathogens present in patient rooms at 2 metropolitan hospitals before and after application of a continuously active antimicrobial surface coating. Methods: A continuously active antimicrobial surface coating was applied to patient rooms in intensive care units (ICUs) twice over an 18-month period and in non-ICUs twice over a 6-month study period. The environmental bioburden was assessed 8–16 weeks after each treatment. A 100-cm2 area was swabbed from frequently touched areas in patient rooms: patient chair arm rest, bed rail, TV remote, and backsplash behind the sink. The total aerobic bacteria count was determined for each location by enumeration on tryptic soy agar (TSA); the geometric mean was used to compare bioburden before and after treatment. Each sample was also plated on selective agar for carbapenem-resistant Enterobacteriaceae (CRE), vancomycin-resistant enterococci (VRE), methicillin-resistant Staphylococcus aureus (MRSA), and Clostridioides difficile to determine whether pathogens were present. Pathogen incidence was calculated as the percentage of total sites positive for at least 1 of the 4 target organisms. Results: Before application of the antimicrobial coating, total aerobic bacteria counts in ICUs were >1,500 CFU/100 cm2, and at least 30% of the sites were positive for a target pathogen (ie, CRE, VRE, MRSA or C. difficile). In non-ICUs, the bioburden before treatment was at least 500 CFU/100 cm2, with >50% of sites being contaminated with a pathogen. After successive applications of the surface coating, total aerobic bacteria were reduced by >80% in the ICUs and >40% in the non-ICUs. Similarly, the incidence of pathogen-positive sites was reduced by at least 50% in both ICUs and non-ICUs. Conclusions: The use of a continuously active antimicrobial surface coating provides a significant (P < .01) and sustained reduction in aerobic bacteria while also reducing the occurrence of epidemiologically important pathogens on frequently touched surfaces in patient rooms. These findings support the use of novel antimicrobial technologies as an additional layer of protection against the transmission of potentially harmful bacteria from contaminated surfaces to patients.Funding: Allied BioScience provided Funding: for this study.Disclosures: Valerie Beck reports salary from Allied BioScience.

scholarly journals ATLAS IBL: integration of new HW/SW readout features for the additional layer of Pixel Detector

2011 ◽  
Vol 6 (01) ◽  
pp. C01018-C01018
Author(s):  
G Bruni ◽  
M Bruschi ◽  
I D'Antone ◽  
J Dopke ◽  
D Falchieri ◽  
...  
Keyword(s):  
Pixel Detector ◽  
Additional Layer

Improving the photodetection and stability of a visible-light QDs/ZnO phototransistor via an Al2O3 additional layer

2021 ◽  
Author(s):  
Sungho Park ◽  
Byung Jun Kim ◽  
Tae Yeon Kim ◽  
Eui Young Jung ◽  
Kyu-Myung Lee ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Atomic Layer Deposition ◽  
Quantum Dot ◽  
Aluminum Oxide ◽  
Thin Layer ◽  
Visible Light ◽  
Atomic Layer ◽  
Zno Films ◽  
Additional Layer ◽  
Layer Deposition

We have developed a visible-light phototransistor with excellent photodetection characteristics and stability via atomic layer deposition (ALD) to add a thin layer of aluminum oxide (Al2O3) to quantum dot (QD)/zinc oxide (ZnO) films.

scholarly journals Leveraging Multiple Layers of Data To Predict Drosophila Complex Traits

2020 ◽  
Vol 10 (12) ◽  
pp. 4599-4613
Author(s):  
Fabio Morgante ◽  
Wen Huang ◽  
Peter Sørensen ◽  
Christian Maltecca ◽  
Trudy F. C. Mackay
Keyword(s):  
Precision Agriculture ◽  
Complex Traits ◽  
Prediction Accuracy ◽  
Cellular Response ◽  
Complex Trait ◽  
Sources Of Information ◽  
Starvation Resistance ◽  
Expression Levels ◽  
Chill Coma ◽  
Additional Layer

The ability to accurately predict complex trait phenotypes from genetic and genomic data are critical for the implementation of personalized medicine and precision agriculture; however, prediction accuracy for most complex traits is currently low. Here, we used data on whole genome sequences, deep RNA sequencing, and high quality phenotypes for three quantitative traits in the ∼200 inbred lines of the Drosophila melanogaster Genetic Reference Panel (DGRP) to compare the prediction accuracies of gene expression and genotypes for three complex traits. We found that expression levels (r = 0.28 and 0.38, for females and males, respectively) provided higher prediction accuracy than genotypes (r = 0.07 and 0.15, for females and males, respectively) for starvation resistance, similar prediction accuracy for chill coma recovery (null for both models and sexes), and lower prediction accuracy for startle response (r = 0.15 and 0.14 for female and male genotypes, respectively; and r = 0.12 and 0.11, for females and male transcripts, respectively). Models including both genotype and expression levels did not outperform the best single component model. However, accuracy increased considerably for all the three traits when we included gene ontology (GO) category as an additional layer of information for both genomic variants and transcripts. We found strongly predictive GO terms for each of the three traits, some of which had a clear plausible biological interpretation. For example, for starvation resistance in females, GO:0033500 (r = 0.39 for transcripts) and GO:0032870 (r = 0.40 for transcripts), have been implicated in carbohydrate homeostasis and cellular response to hormone stimulus (including the insulin receptor signaling pathway), respectively. In summary, this study shows that integrating different sources of information improved prediction accuracy and helped elucidate the genetic architecture of three Drosophila complex phenotypes.

Electron Microprobe Correlation of Tephra Layers from Eastern Mediterranean Abyssal Sediments and the Island of Santorini

1980 ◽  
Vol 13 (2) ◽  
pp. 160-171 ◽  
Author(s):  
Alan N. Federman ◽  
Steven N. Carey
Keyword(s):  
Major Element ◽  
Late Quaternary ◽  
Eastern Mediterranean ◽  
Explosive Eruptions ◽  
Volcanic Complex ◽  
Quaternary Sediments ◽  
Additional Layer ◽  
Oxygen Isotope Stratigraphy ◽  
Tephra Layers ◽  
Isotope Stratigraphy

AbstractFive widespread tephra layers are found in late Quaternary sediments (0–130,000 yr B.P.) of the Eastern Mediterranean Sea. These layers have been correlated among abyssal cores and to their respective terrestrial sources by electron-probe microanalysis of glass and pumice shards. Major element variations are sufficient to discriminate unambiguously between the five major layers. Oxygen isotope stratigraphy in one of the cores studied was used to data four of the five layers. Two of the widespread layers are derived from explosive eruptions of the Santorini volcanic complex: the Minoan Ash (3370 yr B.P.) and the Acrotiri Ignimbrite (18,000 yr B.P.). An additional layer, found in one core only, is most likely correlated to the Middle Pumice Series of Santorini (approximately 100,000 yr B.P.). Two layers are correlated to deposits on the islands of Yali and Kos and date to 31,000 and 120,000 yr B.P., respectively. One layer originated from the Neapolitan area of Italy 38,000 yr B.P.

Histopathology of the A1 Pulley in Adult Trigger Fingers

2007 ◽  
Vol 32 (5) ◽  
pp. 556-559 ◽  
Author(s):  
M. C. SBERNARDORI ◽  
P. BANDIERA
Keyword(s):  
Connective Tissue ◽  
Middle Layer ◽  
Laminar Structure ◽  
Loose Connective Tissue ◽  
Control Series ◽  
Outermost Layer ◽  
Additional Layer ◽  
Transmission Electron ◽  
Electron Microscopes ◽  
A1 Pulley

The histopathology of the central parts of 40 A1 pulleys from adult patients with primary trigger fingers was studied using light and transmission electron microscopes and the findings were compared with those in a control series of 10 normal A1 pulleys. The evaluation of the normal A1 pulley revealed a bi-laminar structure. The deepest layer was composed of dense normal connective tissue. The outermost layer was formed by loose connective tissue. In trigger digits, it was possible to identify a tri-laminar structure. The deepest layer was composed of irregular connective tissue, formed by small collagen fibres and abundant extracellular matrix. A considerable amount of chondroid-metaplasia was present in this layer. The middle layer contained dense, normal connective tissue with some fibrocytes. The outermost layer was formed of loose connective tissue. In conclusion, there was an additional layer in the A1 pulley in pathological cases which was not present in normal pulleys.

scholarly journals Ribosomal RNA 2′O-methylation as a novel layer of inter-tumour heterogeneity in breast cancer

NAR Cancer ◽  
2020 ◽  
Vol 2 (4) ◽  
Author(s):  
Virginie Marcel ◽  
Janice Kielbassa ◽  
Virginie Marchand ◽  
Kundhavai S Natchiar ◽  
Hermes Paraqindes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ribosomal Rna ◽  
Large Scale ◽  
Gene Expression Regulation ◽  
Molecular Signature ◽  
Translation Control ◽  
Breast Tumours ◽  
Cellular Models ◽  
Additional Layer ◽  
Tumour Biology

Abstract Recent epitranscriptomics studies unravelled that ribosomal RNA (rRNA) 2′O-methylation is an additional layer of gene expression regulation highlighting the ribosome as a novel actor of translation control. However, this major finding lies on evidences coming mainly, if not exclusively, from cellular models. Using the innovative next-generation RiboMeth-seq technology, we established the first rRNA 2′O-methylation landscape in 195 primary human breast tumours. We uncovered the existence of compulsory/stable sites, which show limited inter-patient variability in their 2′O-methylation level, which map on functionally important sites of the human ribosome structure and which are surrounded by variable sites found from the second nucleotide layers. Our data demonstrate that some positions within the rRNA molecules can tolerate absence of 2′O-methylation in tumoral and healthy tissues. We also reveal that rRNA 2′O-methylation exhibits intra- and inter-patient variability in breast tumours. Its level is indeed differentially associated with breast cancer subtype and tumour grade. Altogether, our rRNA 2′O-methylation profiling of a large-scale human sample collection provides the first compelling evidence that ribosome variability occurs in humans and suggests that rRNA 2′O-methylation might represent a relevant element of tumour biology useful in clinic. This novel variability at molecular level offers an additional layer to capture the cancer heterogeneity and associates with specific features of tumour biology thus offering a novel targetable molecular signature in cancer.

Experimental Investigation of the Compatibility of Lime Coating with Insulation Straw Biocomposite

2022 ◽  
Author(s):  
Oumayma Bahou ◽  
Naima Belayachi ◽  
Brahim Ismail
Keyword(s):  
Experimental Investigation ◽  
Building Materials ◽  
Construction Sector ◽  
Additional Layer ◽  
Aesthetic Appearance ◽  
Innovative Solutions ◽  
Casein Protein ◽  
The Subject ◽  
Considerable Degradation ◽  
Bond Tests

The use of bio-based composite as building materials is one of the innovative solutions for dealing with environmental disorders caused by the construction sector. Among these materials we find biocomposites based on vegetable aggregates, which have proven their effectiveness as insulating materials in numerous studies. Despite the growing interest in these materials and the recognition of their performance, their use remains hampered by the lack of implementation rules specific to these materials to move towards a control of their use and their durability affected by the climate and use conditions to which they will be exposed at the level of a building. The objective of this work is to study the compatibility of a protective coating with a block substrate of biocomposites based on cereal straw. It is in fact a mixture of vegetable aggregates (straw), a binder composed of lime and additives also obtained from a renewable source (Ismail et al., 2020). These additives (air-entraining agent, casein protein and a biopolymer) have been added to improve both the fibre-binder interface and the porosity of the binder. The use of these bio-based materials for external or internal thermal insulation of the building requires the application of a coating to protect them against climatic aggressions and to give them an aesthetic appearance. The lime-based coatings, air-entraining agent and casein protein selected for this study have been the subject of an experimental investigation (Brahim Ismail, 2020). In order to assess the compatibility of these coatings with the straw-based insulating material, we were interested in studying the adhesion between the biocomposite and the coating after aging cycles in accordance with the EN 1015-21 standard. The samples (biocomposite + coating) were subjected to two types of aging, one using water and the other using a saline solution of sodium sulphates (Na2SO4). The results of the bond tests after aging showed that the cohesive fracture (at the level of the substrate) is a pattern observed in all the studied systems. In Addition, It has been found that the coating to which a percentage of fine fibers has been added undergoes considerable degradation after aging with salt solution, demonstrating the need of an additional layer of outer coating without fibers in order to ensure the sustainability of the system.

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