On fusion and multiple copy spell-out

Author(s):  
Jason Kandybowicz
Keyword(s):  
Genetics ◽  
1997 ◽  
Vol 147 (3) ◽  
pp. 1213-1224
Author(s):  
Jean-Philippe Charles ◽  
Carol Chihara ◽  
Shamim Nejad ◽  
Lynn M Riddiford

A 36-kb genomic DNA segment of the Drosophila melanogaster genome containing 12 clustered cuticle genes has been mapped and partially sequenced. The cluster maps at 65A 5-6 on the left arm of the third chromosome, in agreement with the previously determined location of a putative cluster encompassing the genes for the third instar larval cuticle proteins LCP5, LCP6 and LCP8. This cluster is the largest cuticle gene cluster discovered to date and shows a number of surprising features that explain in part the genetic complexity of the LCP5, LCP6 and LCP8 loci. The genes encoding LCP5 and LCP8 are multiple copy genes and the presence of extensive similarity in their coding regions gives the first evidence for gene conversion in cuticle genes. In addition, five genes in the cluster are intronless. Four of these five have arisen by retroposition. The other genes in the cluster have a single intron located at an unusual location for insect cuticle genes.


2020 ◽  
Author(s):  
Tim Shephard

Abstract Modern evaluations of the relation between music and the fashion for the antique in Italy in the period before the madrigal have tended to proceed from the perspective of intellectual history. This article aims to offer an alternative—although certainly related—perspective, by exploring the circulation of musical classicisms in Italian visual and material culture, roughly from 1450 to 1520. This period saw the rise to prominence in Italy of both commercial text printing and other multiple-copy formats such as the art print, the medal, the bronze plaquette, and a little later historiated maiolica. These technologies offer a particularly compelling lens through which to examine musical encounters with classical antiquity that were not motivated by an expert professional interest in either music or classical texts, but rather characterized by an investment in antiquity as a fashionable source of cultural capital.


2016 ◽  
Vol 170 (4) ◽  
pp. 986-991 ◽  
Author(s):  
Karen G. Scheps ◽  
Liliana Francipane ◽  
Julián Nevado ◽  
Nora Basack ◽  
Myriam Attie ◽  
...  

2014 ◽  
Vol 106 (2) ◽  
pp. 412a
Author(s):  
Wei Jiang ◽  
James Phillips ◽  
Lei Huang ◽  
Mikolai Fajer ◽  
Yilin Meng ◽  
...  

Author(s):  
Gokul Nair ◽  
Kaustubh Venkatesh ◽  
Dipankar Sen ◽  
Reena Sonkusare
Keyword(s):  

2020 ◽  
Author(s):  
Idowu Olawoye ◽  
Simon D.W. Frost ◽  
Christian T. Happi

Abstract Background: Mycobacterium tuberculosis complex (MTBC) consists of seven major lineages with three of them reported to circulate within West Africa: lineage 5 (West African 1) and lineage 6 (West African 2) which are geographically restricted to West Africa and lineage 4 (Euro-American lineage) which is found globally. It is unclear why the West African lineages are not found elsewhere; some hypotheses suggest that it could either be harboured by an animal reservoir which is restricted to West Africa, or strain preference for hosts of West African ethnicity, or inability to compete with other lineages in other locations.We tested the hypothesis that M. africanum West African 2 (lineage 6) might have emigrated out of West Africa but was outcompeted by more virulent modern strains of M. tuberculosis (MTB).Whole genome sequences of M. tuberculosis from Nigeria (n=21), South Africa (n=24) and M. africanum West African 2 from Mali (n=22) were retrieved, and a pan-genome analysis was performed after fully annotating these genomes. Results: The outcome of this analysis shows that Lineages 2, 4 and 6 all have a close pan-genome. We also see a correlation in numbers of some multiple copy core genes and amino acid substitution with lineage specificity that may have contributed to geographical distribution of these lineages.Conclusions: The findings in this study provides a perspective to one of the hypotheses that M. africanum West African 2 might find it difficult to compete against the more modern lineages outside West Africa hence its localization to the geographical region.


1971 ◽  
Vol 4 (2) ◽  
pp. 64
Author(s):  
Robert S. Grant

<p class="p1">An industrial inventory technique adapted to a university library's computer based circulation system as one aid in identifying heavily used books <span class="s1">for </span>multiple-copy <span class="s1">purchase.</span></p>


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