scholarly journals Inhibition of Glycogen-synthase Kinase 3 Stimulates Glycogen Synthase and Glucose Transport by Distinct Mechanisms in 3T3-L1 Adipocytes

2000 ◽  
Vol 275 (21) ◽  
pp. 15765-15772 ◽  
Author(s):  
Stephen J. Oreña ◽  
Anthony J. Torchia ◽  
Robert S. Garofalo
Keyword(s):  
Glucose Transport ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3

scholarly journals Selective Glycogen Synthase Kinase 3 Inhibitors Potentiate Insulin Activation of Glucose Transport and Utilization In Vitro and In Vivo

Diabetes ◽  
2003 ◽  
Vol 52 (3) ◽  
pp. 588-595 ◽  
Author(s):  
D. B. Ring ◽  
K. W. Johnson ◽  
E. J. Henriksen ◽  
J. M. Nuss ◽  
D. Goff ◽  
...  
Keyword(s):  
Glucose Transport ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3

scholarly journals Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase

2003 ◽  
Vol 270 (18) ◽  
pp. 3829-3838 ◽  
Author(s):  
Katrina MacAulay ◽  
Eric Hajduch ◽  
Anne S. Blair ◽  
Matthew P. Coghlan ◽  
Stephen A. Smith ◽  
...  
Keyword(s):  
Glucose Transport ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3

scholarly journals A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression

2008 ◽  
Vol 295 (3) ◽  
pp. C836-C843 ◽  
Author(s):  
Carolyn L. Buller ◽  
Robert D. Loberg ◽  
Ming-Hui Fan ◽  
Qihong Zhu ◽  
James L. Park ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Glucose Transport ◽  
Glucose Transporter ◽  
Glycogen Synthase ◽  
Cell Types ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Glucose Transporter 1 ◽  
Glut1 Expression ◽  
Mutant Cells

Glucose transport is a highly regulated process and is dependent on a variety of signaling events. Glycogen synthase kinase-3 (GSK-3) has been implicated in various aspects of the regulation of glucose transport, but the mechanisms by which GSK-3 activity affects glucose uptake have not been well defined. We report that basal glycogen synthase kinase-3 (GSK-3) activity regulates glucose transport in several cell types. Chronic inhibition of basal GSK-3 activity (8–24 h) in several cell types, including vascular smooth muscle cells, resulted in an approximately twofold increase in glucose uptake due to a similar increase in protein expression of the facilitative glucose transporter 1 (GLUT1). Conversely, expression of a constitutively active form of GSK-3β resulted in at least a twofold decrease in GLUT1 expression and glucose uptake. Since GSK-3 can inhibit mammalian target of rapamycin (mTOR) signaling via phosphorylation of the tuberous sclerosis complex subunit 2 (TSC2) tumor suppressor, we investigated whether chronic GSK-3 effects on glucose uptake and GLUT1 expression depended on TSC2 phosphorylation and TSC inhibition of mTOR. We found that absence of functional TSC2 resulted in a 1.5-to 3-fold increase in glucose uptake and GLUT1 expression in multiple cell types. These increases in glucose uptake and GLUT1 levels were prevented by inhibition of mTOR with rapamycin. GSK-3 inhibition had no effect on glucose uptake or GLUT1 expression in TSC2 mutant cells, indicating that GSK-3 effects on GLUT1 and glucose uptake were mediated by a TSC2/mTOR-dependent pathway. The effect of GSK-3 inhibition on GLUT1 expression and glucose uptake was restored in TSC2 mutant cells by transfection of a wild-type TSC2 vector, but not by a TSC2 construct with mutated GSK-3 phosphorylation sites. Thus, TSC2 and rapamycin-sensitive mTOR function downstream of GSK-3 to modulate effects of GSK-3 on glucose uptake and GLUT1 expression. GSK-3 therefore suppresses glucose uptake via TSC2 and mTOR and may serve to match energy substrate utilization to cellular growth.

scholarly journals Stimulation of Electrogenic Glucose Transport by Glycogen Synthase Kinase 3

2010 ◽  
Vol 26 (4-5) ◽  
pp. 641-646 ◽  
Author(s):  
Rexhep Rexhepaj ◽  
Miribane Dërmaku-Sopjani ◽  
Eva-Maria Gehring ◽  
Mentor Sopjani ◽  
Daniela S. Kempe ◽  
...  
Keyword(s):  
Glucose Transport ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Stimulation Of
Sign in / Sign up

Export Citation Format

Share Document