scholarly journals Contribution of Redox Status to Hepatitis C Virus E2 Envelope Protein Function and Antigenicity

2008 ◽  
Vol 283 (39) ◽  
pp. 26340-26348 ◽  
Author(s):  
Emmanuel Fenouillet ◽  
Dimitri Lavillette ◽  
Silvia Loureiro ◽  
George Krashias ◽  
Guillemette Maurin ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Envelope Protein ◽  
Protein Function ◽  
Redox Status

Immunological evaluation of Escherichia coli -derived hepatitis C virus second envelope protein (E2) variants

2001 ◽  
Vol 58 (3) ◽  
pp. 221-228 ◽  
Author(s):  
S. Dueñas-Carrera ◽  
A. Viña ◽  
H.E. Garay ◽  
O. Reyes ◽  
L. Alvarez-Lajonchere ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Envelope Protein ◽  
Immunological Evaluation

Antigenicity and B-epitope mapping of hepatitis C virus envelope protein E2

2009 ◽  
Vol 3 (2) ◽  
pp. 177-182 ◽  
Author(s):  
T. I. Kuzmina ◽  
L. V. Olenina ◽  
M. A. Sanzhakov ◽  
T. E. Farafonova ◽  
T. V. Abramihina ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Envelope Protein ◽  
Epitope Mapping ◽  
Virus Envelope ◽  
Virus Envelope Protein

scholarly journals Monoclonal Antibody AP33 Defines a Broadly Neutralizing Epitope on the Hepatitis C Virus E2 Envelope Glycoprotein

2005 ◽  
Vol 79 (17) ◽  
pp. 11095-11104 ◽  
Author(s):  
Ania Owsianka ◽  
Alexander W. Tarr ◽  
Vicky S. Juttla ◽  
Dimitri Lavillette ◽  
Birke Bartosch ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Envelope Glycoprotein ◽  
Envelope Protein ◽  
Hypervariable Region ◽  
Neutralizing Antibody ◽  
Broadly Neutralizing Antibody ◽  
New Treatments ◽  
Potent Neutralization

ABSTRACT Hepatitis C virus (HCV) remains a significant threat to the general health of the world's population, and there is a pressing need for the development of new treatments and preventative vaccines. Here, we describe the generation of retrovirus-based pseudoparticles (HCVpp) incorporating a panel of full-length E1E2 clones representative of the major genotypes 1 through 6, and their application to assess the reactivity and neutralizing capability of antisera and monoclonal antibodies raised against portions of the HCV E2 envelope protein. Rabbit antisera raised against either the first hypervariable region or ectodomain of E2 showed limited and strain specific neutralization. By contrast, the monoclonal antibody (MAb) AP33 demonstrated potent neutralization of infectivity against HCVpp carrying E1E2 representative of all genotypes tested. The concentration of AP33 required to achieve 50% inhibition of infection by HCVpp of diverse genotypes ranged from 0.6 to 32 μg/ml. The epitope recognized by MAb AP33 is linear and highly conserved across different genotypes of HCV. Thus, identification of a broadly neutralizing antibody that recognizes a linear epitope is likely to be of significant benefit to future vaccine and therapeutic antibody development.

scholarly journals Unexpected Structural Features of the Hepatitis C Virus Envelope Protein 2 Ectodomain

2014 ◽  
Vol 88 (18) ◽  
pp. 10280-10288 ◽  
Author(s):  
A. Sabahi ◽  
S. L. Uprichard ◽  
W. C. Wimley ◽  
S. Dash ◽  
R. F. Garry
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Envelope Protein ◽  
Structural Features ◽  
Virus Envelope ◽  
Virus Envelope Protein

scholarly journals Immunoglobulin mimicry by Hepatitis C Virus envelope protein E2

Virology ◽  
2005 ◽  
Vol 332 (2) ◽  
pp. 538-549 ◽  
Author(s):  
Yu-Wen Hu ◽  
Lynda Rocheleau ◽  
Bryce Larke ◽  
Linda Chui ◽  
Bonita Lee ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Envelope Protein ◽  
Virus Envelope ◽  
Virus Envelope Protein
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