scholarly journals Phosphorylation of HsMis13 by Aurora B Kinase Is Essential for Assembly of Functional Kinetochore

2008 ◽  
Vol 283 (39) ◽  
pp. 26726-26736 ◽  
Author(s):  
Yong Yang ◽  
Fang Wu ◽  
Tarsha Ward ◽  
Feng Yan ◽  
Quan Wu ◽  
...  
Keyword(s):  
Aurora B ◽  
Aurora B Kinase ◽  
Functional Kinetochore

scholarly journals A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans

2005 ◽  
Vol 171 (2) ◽  
pp. 267-279 ◽  
Author(s):  
Anjon Audhya ◽  
Francie Hyndman ◽  
Ian X. McLeod ◽  
Amy S. Maddox ◽  
John R. Yates ◽  
...  
Keyword(s):  
Cell Division ◽  
Caenorhabditis Elegans ◽  
Rna Binding ◽  
Rna Binding Protein ◽  
Rna Helicase ◽  
Aurora B ◽  
Aurora B Kinase ◽  
Daughter Cells ◽  
Sm Protein ◽  
Spindle Structure

Cytokinesis completes cell division and partitions the contents of one cell to the two daughter cells. Here we characterize CAR-1, a predicted RNA binding protein that is implicated in cytokinesis. CAR-1 localizes to germline-specific RNA-containing particles and copurifies with the essential RNA helicase, CGH-1, in an RNA-dependent fashion. The atypical Sm domain of CAR-1, which directly binds RNA, is dispensable for CAR-1 localization, but is critical for its function. Inhibition of CAR-1 by RNA-mediated depletion or mutation results in a specific defect in embryonic cytokinesis. This cytokinesis failure likely results from an anaphase spindle defect in which interzonal microtubule bundles that recruit Aurora B kinase and the kinesin, ZEN-4, fail to form between the separating chromosomes. Depletion of CGH-1 results in sterility, but partially depleted worms produce embryos that exhibit the CAR-1–depletion phenotype. Cumulatively, our results suggest that CAR-1 functions with CGH-1 to regulate a specific set of maternally loaded RNAs that is required for anaphase spindle structure and cytokinesis.

scholarly journals Aurora B kinase activation requires survivin priming phosphorylation by PLK1

2010 ◽  
Vol 3 (4) ◽  
pp. 260-267 ◽  
Author(s):  
Youjun Chu ◽  
Phil Y. Yao ◽  
Wenwen Wang ◽  
Dongmei Wang ◽  
Zhikai Wang ◽  
...  
Keyword(s):  
Aurora B ◽  
Aurora B Kinase ◽  
Kinase Activation

scholarly journals Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152

Oncogene ◽  
2007 ◽  
Vol 27 (23) ◽  
pp. 3244-3255 ◽  
Author(s):  
Y Tao ◽  
P Zhang ◽  
F Girdler ◽  
V Frascogna ◽  
M Castedo ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Kinase Inhibitor ◽  
Radiation Response ◽  
Aurora B ◽  
Aurora B Kinase

scholarly journals Cdc14-regulated midzone assembly controls anaphase B

2007 ◽  
Vol 177 (6) ◽  
pp. 981-993 ◽  
Author(s):  
Anton Khmelinskii ◽  
Clare Lawrence ◽  
Johanna Roostalu ◽  
Elmar Schiebel
Keyword(s):  
Cell Cycle ◽  
Protein Phosphatase ◽  
Cross Linking ◽  
Aurora B ◽  
Aurora B Kinase ◽  
Spindle Midzone ◽  
A Cell ◽  
Spindle Elongation ◽  
And Function ◽  
Anaphase B

Spindle elongation in anaphase of mitosis is a cell cycle–regulated process that requires coordination between polymerization, cross-linking, and sliding of microtubules (MTs). Proteins that assemble at the spindle midzone may be important for this process. In this study, we show that Ase1 and the separase–Slk19 complex drive midzone assembly in yeast. Whereas the conserved MT-bundling protein Ase1 establishes a midzone, separase–Slk19 is required to focus and center midzone components. An important step leading to spindle midzone assembly is the dephosphorylation of Ase1 by the protein phosphatase Cdc14 at the beginning of anaphase. Failure to dephosphorylate Ase1 delocalizes midzone proteins and delays the second, slower phase of anaphase B. In contrast, in cells expressing nonphosphorylated Ase1, anaphase spindle extension is faster, and spindles frequently break. Cdc14 also controls the separase–Slk19 complex indirectly via the Aurora B kinase. Thus, Cdc14 regulates spindle midzone assembly and function directly through Ase1 and indirectly via the separase–Slk19 complex.

scholarly journals Endopolyploidy in irradiated p53-deficient tumour cell lines: Persistence of cell division activity in giant cells expressing Aurora-B kinase

2008 ◽  
Vol 32 (9) ◽  
pp. 1044-1056 ◽  
Author(s):  
Jekaterina Erenpreisa ◽  
Andrei Ivanov ◽  
Sally P. Wheatley ◽  
Elizabeth A. Kosmacek ◽  
Fiorenza Ianzini ◽  
...  
Keyword(s):  
Cell Division ◽  
Cell Lines ◽  
Tumour Cell ◽  
Giant Cells ◽  
Aurora B ◽  
Aurora B Kinase ◽  
Tumour Cell Lines
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