Transforming Growth Factor-β Requires Its Target Plasminogen Activator Inhibitor-1 for Cytostatic Activity

Roderik M. Kortlever; Jeroen H. Nijwening; René Bernards

doi:10.1074/jbc.m803341200

Transforming Growth Factor-β Requires Its Target Plasminogen Activator Inhibitor-1 for Cytostatic Activity

Journal of Biological Chemistry ◽

10.1074/jbc.m803341200 ◽

2008 ◽

Vol 283 (36) ◽

pp. 24308-24313 ◽

Cited By ~ 32

Author(s):

Roderik M. Kortlever ◽

Jeroen H. Nijwening ◽

René Bernards

Keyword(s):

Growth Factor ◽

Plasminogen Activator ◽

Transforming Growth Factor ◽

Plasminogen Activator Inhibitor ◽

Transforming Growth Factor Β ◽

Cytostatic Activity ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor

Download Full-text

Glucocorticoid enhances hypoxia- and/or transforming growth factor-β-induced plasminogen activator inhibitor-1 production in human proximal renal tubular cells

Clinical and Experimental Nephrology ◽

10.1007/s10157-010-0351-7 ◽

2010 ◽

Vol 15 (1) ◽

pp. 34-40 ◽

Cited By ~ 8

Author(s):

Hideki Kimura ◽

Xuan Li ◽

Kunio Torii ◽

Toshiharu Okada ◽

Kazuko Kamiyama ◽

...

Keyword(s):

Growth Factor ◽

Plasminogen Activator ◽

Transforming Growth Factor ◽

Plasminogen Activator Inhibitor ◽

Transforming Growth Factor Β ◽

Plasminogen Activator Inhibitor 1 ◽

Tubular Cells ◽

Renal Tubular Cells ◽

Renal Tubular ◽

Activator Inhibitor

Download Full-text

Radiation and Transforming Growth Factor-β Cooperate in Transcriptional Activation of the Profibrotic Plasminogen Activator Inhibitor-1 Gene

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-05-0427 ◽

2005 ◽

Vol 11 (16) ◽

pp. 5956-5964 ◽

Cited By ~ 32

Author(s):

Jurre Hageman ◽

Bart J. Eggen ◽

Tom Rozema ◽

Kevin Damman ◽

Harm H. Kampinga ◽

...

Keyword(s):

Growth Factor ◽

Plasminogen Activator ◽

Transcriptional Activation ◽

Transforming Growth Factor ◽

Plasminogen Activator Inhibitor ◽

Transforming Growth Factor Β ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor

Download Full-text

Forkhead transcription factor FoxO1 inhibits insulin- and transforming growth factor-β-stimulated plasminogen activator inhibitor-1 expression

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2009.06.124 ◽

2009 ◽

Vol 386 (4) ◽

pp. 757-761 ◽

Cited By ~ 7

Author(s):

Yun-A. Jung ◽

Kyeong-Min Lee ◽

Mi-Kyung Kim ◽

Gwon-Soo Jung ◽

Ye-Jin Seo ◽

...

Keyword(s):

Transcription Factor ◽

Growth Factor ◽

Plasminogen Activator ◽

Transforming Growth Factor ◽

Plasminogen Activator Inhibitor ◽

Transforming Growth Factor Β ◽

Plasminogen Activator Inhibitor 1 ◽

Forkhead Transcription Factor ◽

Activator Inhibitor

Download Full-text

Smad4/DPC4 and Smad3 Mediate Transforming Growth Factor-β (TGF-β) Signaling through Direct Binding to a Novel TGF-β-responsive Element in the Human Plasminogen Activator Inhibitor-1 Promoter

Journal of Biological Chemistry ◽

10.1074/jbc.273.45.29287 ◽

1998 ◽

Vol 273 (45) ◽

pp. 29287-29290 ◽

Cited By ~ 104

Author(s):

Chao-Zhong Song ◽

Tara E. Siok ◽

Thomas D. Gelehrter

Keyword(s):

Growth Factor ◽

Plasminogen Activator ◽

Transforming Growth Factor ◽

Plasminogen Activator Inhibitor ◽

Transforming Growth Factor Β ◽

Plasminogen Activator Inhibitor 1 ◽

Direct Binding ◽

Human Plasminogen ◽

Responsive Element ◽

Activator Inhibitor

Download Full-text

Decorin suppresses transforming growth factor-β-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240

Biochemical Journal ◽

10.1042/0264-6021:3620643 ◽

2002 ◽

Vol 362 (3) ◽

pp. 643 ◽

Cited By ~ 22

Author(s):

Nadia ABDEL-WAHAB ◽

Stephen J. WICKS ◽

Roger M. MASON ◽

Andrew CHANTRY

Keyword(s):

Growth Factor ◽

Plasminogen Activator ◽

Transforming Growth Factor ◽

Mesangial Cells ◽

Plasminogen Activator Inhibitor ◽

Transforming Growth Factor Β ◽

Plasminogen Activator Inhibitor 1 ◽

Induced Expression ◽

Human Mesangial Cells ◽

Activator Inhibitor

Download Full-text

Quantification of Transforming Growth Factor-β in Biological Material Using Cells Transfected with a Plasminogen Activator Inhibitor-1 Promoter–Luciferase Construct

Analytical Biochemistry ◽

10.1006/abio.1997.2026 ◽

1997 ◽

Vol 247 (1) ◽

pp. 45-51 ◽

Cited By ~ 41

Author(s):

M.A.W.H. van Waarde ◽

A.J. van Assen ◽

H.H. Kampinga ◽

A.W.T. Konings ◽

Z. Vujaskovic

Keyword(s):

Growth Factor ◽

Plasminogen Activator ◽

Biological Material ◽

Transforming Growth Factor ◽

Plasminogen Activator Inhibitor ◽

Transforming Growth Factor Β ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor

Download Full-text

Decorin suppresses transforming growth factor-β-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240

Biochemical Journal ◽

10.1042/bj3660999u ◽

2002 ◽

Vol 366 (3) ◽

pp. 999-999

Author(s):

N. ABDEL-WAHAB ◽

S.J. WICKS ◽

R.M. MASON ◽

A. CHANTRY

Keyword(s):

Growth Factor ◽

Plasminogen Activator ◽

Transforming Growth Factor ◽

Mesangial Cells ◽

Plasminogen Activator Inhibitor ◽

Transforming Growth Factor Β ◽

Plasminogen Activator Inhibitor 1 ◽

Induced Expression ◽

Human Mesangial Cells ◽

Activator Inhibitor

Download Full-text

An Assay for Transforming Growth Factor-β Using Cells Transfected with a Plasminogen Activator Inhibitor-1 Promoter-Luciferase Construct

Analytical Biochemistry ◽

10.1006/abio.1994.1042 ◽

1994 ◽

Vol 216 (2) ◽

pp. 276-284 ◽

Cited By ~ 562

Author(s):

M. Abe ◽

J.G. Harpel ◽

C.N. Metz ◽

I. Nunes ◽

D.J. Loskutoff ◽

...

Keyword(s):

Growth Factor ◽

Plasminogen Activator ◽

Transforming Growth Factor ◽

Plasminogen Activator Inhibitor ◽

Transforming Growth Factor Β ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor

Download Full-text

Requirements for Transforming Growth Factor-β Regulation of the Pro-α2(I) Collagen and Plasminogen Activator Inhibitor-1 Promoters

Journal of Biological Chemistry ◽

10.1074/jbc.270.9.4473 ◽

1995 ◽

Vol 270 (9) ◽

pp. 4473-4477 ◽

Cited By ~ 39

Author(s):

Enoch Chang ◽

Howard Goldberg

Keyword(s):

Growth Factor ◽

Plasminogen Activator ◽

Transforming Growth Factor ◽

Plasminogen Activator Inhibitor ◽

Transforming Growth Factor Β ◽

Plasminogen Activator Inhibitor 1 ◽

Activator Inhibitor

Download Full-text

Regulation of Plasminogen Activator Inhibitor-1 Expression by Transforming Growth Factor-β-induced Physical and Functional Interactions between Smads and Sp1

Journal of Biological Chemistry ◽

10.1074/jbc.c000508200 ◽

2000 ◽

Vol 275 (51) ◽

pp. 40014-40019 ◽

Cited By ~ 102

Author(s):

Pran K. Datta ◽

Michael C. Blake ◽

Harold L. Moses

Keyword(s):

Growth Factor ◽

Plasminogen Activator ◽

Transforming Growth Factor ◽

Plasminogen Activator Inhibitor ◽

Transforming Growth Factor Β ◽

Plasminogen Activator Inhibitor 1 ◽

Functional Interactions ◽

Activator Inhibitor

Download Full-text