scholarly journals HMGA2 and Smads Co-regulate SNAIL1 Expression during Induction of Epithelial-to-Mesenchymal Transition

2008 ◽  
Vol 283 (48) ◽  
pp. 33437-33446 ◽  
Author(s):  
Sylvie Thuault ◽  
E-Jean Tan ◽  
Hector Peinado ◽  
Amparo Cano ◽  
Carl-Henrik Heldin ◽  
...  
Keyword(s):  
Epithelial To Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Snail1 Expression

scholarly journals Snail1: A Transcriptional Factor Controlled at Multiple Levels

2019 ◽  
Vol 8 (6) ◽  
pp. 757 ◽  
Author(s):  
Josep Baulida ◽  
Víctor M. Díaz ◽  
Antonio García de Herreros
Keyword(s):  
Gene Transcription ◽  
Epithelial To Mesenchymal Transition ◽  
Transcriptional Repressor ◽  
Transcriptional Factor ◽  
Protein Modifications ◽  
Mesenchymal Transition ◽  
Fibroblast Activation ◽  
Multiple Levels ◽  
And Function ◽  
Snail1 Expression

Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition and fibroblast activation. As a consequence, Snail1 expression and function is regulated at multiple levels from gene transcription to protein modifications, affecting its interaction with specific cofactors. In this review, we describe the different elements that control Snail1 expression and its activity both as transcriptional repressor or activator.

scholarly journals Pinin Induces Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma by Regulating m6A Modification

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Kailiang Qiao ◽  
Caihong Chen ◽  
Haoyang Liu ◽  
Yuan Qin ◽  
Huijuan Liu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Epithelial To Mesenchymal Transition ◽  
Malignant Progression ◽  
Mechanism Study ◽  
Mesenchymal Transition ◽  
Moonlighting Protein ◽  
Anticancer Target ◽  
Snail1 Expression

Pinin is a moonlighting protein localized in desmosomes and nucleus. It could promote the growth of hepatocellular carcinoma. Whether this protein can induce epithelial-to-mesenchymal transition (EMT) and malignant progression in HCC is unknown. This work found that Pinin prompts EMT in vitro and in vivo. Further mechanism study found that Pinin increases the level of N6-methyladenosine (m6A) modification of RNA by interacting with METTL3, which in turn induces snail1 expression. These findings suggest that Pinin induces EMT by regulating m6A modification and, thus, could be a potential anticancer target for HCC therapy.

The role of DUBs in the post-translational control of cell migration

2019 ◽  
Vol 63 (5) ◽  
pp. 579-594 ◽  
Author(s):  
Guillem Lambies ◽  
Antonio García de Herreros ◽  
Víctor M. Díaz
Keyword(s):  
Cell Migration ◽  
Translational Control ◽  
Epithelial To Mesenchymal Transition ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Mesenchymal Transition ◽  
Tgfβ Receptors ◽  
Fundamental Process ◽  
Multistep Process

Abstract Cell migration is a multifactorial/multistep process that requires the concerted action of growth and transcriptional factors, motor proteins, extracellular matrix remodeling and proteases. In this review, we focus on the role of transcription factors modulating Epithelial-to-Mesenchymal Transition (EMT-TFs), a fundamental process supporting both physiological and pathological cell migration. These EMT-TFs (Snail1/2, Twist1/2 and Zeb1/2) are labile proteins which should be stabilized to initiate EMT and provide full migratory and invasive properties. We present here a family of enzymes, the deubiquitinases (DUBs) which have a crucial role in counteracting polyubiquitination and proteasomal degradation of EMT-TFs after their induction by TGFβ, inflammatory cytokines and hypoxia. We also describe the DUBs promoting the stabilization of Smads, TGFβ receptors and other key proteins involved in transduction pathways controlling EMT.

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