scholarly journals Plk1-dependent Phosphorylation Regulates Functions of DNA Topoisomerase IIα in Cell Cycle Progression

2008 ◽  
Vol 283 (10) ◽  
pp. 6209-6221 ◽  
Author(s):  
Hongchang Li ◽  
Yun Wang ◽  
Xiaoqi Liu
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Topoisomerase Iiα ◽  
Dna Topoisomerase ◽  
Cycle Progression ◽  
Dna Topoisomerase Iiα

scholarly journals Effects of thiols on topoisomerase‐IIα activity and cell cycle progression

1998 ◽  
Vol 31 (5-6) ◽  
pp. 217-229 ◽  
Author(s):  
D. J. Grdina ◽  
J. S. Murley ◽  
J. C. Roberts
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Topoisomerase Iiα ◽  
Cycle Progression

Down-Regulation of DNA Topoisomerase IIα Leads to Prolonged Cell Cycle Transit in G2 and Early M Phases and Increased Survival to Microtubule-Interacting Agents

2005 ◽  
Vol 68 (3) ◽  
pp. 625-634 ◽  
Author(s):  
Andrzej Skladanowski ◽  
Marie-George Côme ◽  
Michal Sabisz ◽  
Alexandre E. Escargueil ◽  
Annette K. Larsen
Keyword(s):  
Cell Cycle ◽  
Down Regulation ◽  
Topoisomerase Iiα ◽  
Dna Topoisomerase ◽  
Interacting Agents ◽  
Dna Topoisomerase Iiα

scholarly journals Cell Cycle-Dependent Control and Roles of DNA Topoisomerase II

Genes ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 859 ◽  
Author(s):  
Joyce H. Lee ◽  
James M. Berger
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Topoisomerase Ii ◽  
Type Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Cycle Progression ◽  
Double Stranded Dna ◽  
Topo Ii ◽  
Cycle Dependent

Type II topoisomerases are ubiquitous enzymes in all branches of life that can alter DNA superhelicity and unlink double-stranded DNA segments during processes such as replication and transcription. In cells, type II topoisomerases are particularly useful for their ability to disentangle newly-replicated sister chromosomes. Growing lines of evidence indicate that eukaryotic topoisomerase II (topo II) activity is monitored and regulated throughout the cell cycle. Here, we discuss the various roles of topo II throughout the cell cycle, as well as mechanisms that have been found to govern and/or respond to topo II function and dysfunction. Knowledge of how topo II activity is controlled during cell cycle progression is important for understanding how its misregulation can contribute to genetic instability and how modulatory pathways may be exploited to advance chemotherapeutic development.

Cytotoxic alkaloids from Pogonopus tubulosus : G2/M cell cycle arrest and inhibition of DNA topoisomerase IIα by isotubulosine

2018 ◽  
Vol 32 (5) ◽  
pp. 943-948 ◽  
Author(s):  
Kelly Juliana Filippin ◽  
Aymee Portela ◽  
Edilene Delphino Rodrigues ◽  
Maria de Fátima Cepa Matos ◽  
Gil Valdo José da Silva ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
M Cell ◽  
Topoisomerase Iiα ◽  
Dna Topoisomerase ◽  
Cycle Arrest ◽  
Dna Topoisomerase Iiα

Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIα expression☆

2001 ◽  
Vol 61 (7) ◽  
pp. 795-802 ◽  
Author(s):  
Leonardo Salmena ◽  
Viengthong Lam ◽  
J Peter McPherson ◽  
Gerald J Goldenberg
Keyword(s):  
Cell Cycle ◽  
Proteasomal Degradation ◽  
Topoisomerase Iiα ◽  
Dna Topoisomerase ◽  
Cycle Dependent ◽  
Dna Topoisomerase Iiα

DNA topoisomerase II-dependent control of the cell cycle progression in root meristems ofAllium cepa

2013 ◽  
Vol 38 (3) ◽  
pp. 355-367 ◽  
Author(s):  
Aneta Żabka ◽  
Justyna Teresa Polit ◽  
Joanna Bernasińska ◽  
Janusz Maszewski
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Cycle Progression ◽  
Root Meristems ◽  
Ofallium Cepa
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