scholarly journals Regulation of Iron Homeostasis Mediated by the Heme-binding Protein Dap1 (Damage Resistance Protein 1) via the P450 Protein Erg11/Cyp51

2007 ◽  
Vol 282 (50) ◽  
pp. 36543-36551 ◽  
Author(s):  
Rolf J. Craven ◽  
Julia C. Mallory ◽  
Randal A. Hand
Keyword(s):  
Iron Homeostasis ◽  
Binding Protein ◽  
Heme Binding ◽  
Damage Resistance ◽  
Resistance Protein ◽  
Heme Binding Protein

scholarly journals The heme-binding protein Dap1 links iron homeostasis to azole resistance via the P450 protein Erg11 inCandida glabrata

2013 ◽  
Vol 13 (4) ◽  
pp. 411-421 ◽  
Author(s):  
Naoki Hosogaya ◽  
Taiga Miyazaki ◽  
Minoru Nagi ◽  
Koichi Tanabe ◽  
Asuka Minematsu ◽  
...  
Keyword(s):  
Iron Homeostasis ◽  
Binding Protein ◽  
Azole Resistance ◽  
Heme Binding ◽  
Heme Binding Protein

scholarly journals What Is Next in This “Age” of Heme-Driven Pathology and Protection by Hemopexin? An Update and Links with Iron

2019 ◽  
Vol 12 (4) ◽  
pp. 144 ◽  
Author(s):  
Luis Montecinos ◽  
Jeffrey D. Eskew ◽  
Ann Smith
Keyword(s):  
Immune System ◽  
Iron Homeostasis ◽  
Binding Protein ◽  
Background Information ◽  
Heme Binding ◽  
Mediated Effects ◽  
Immune System Activation ◽  
Wide Range ◽  
Health And Disease ◽  
Heme Binding Protein

This review provides a synopsis of the published literature over the past two years on the heme-binding protein hemopexin (HPX), with some background information on the biochemistry of the HPX system. One focus is on the mechanisms of heme-driven pathology in the context of heme and iron homeostasis in human health and disease. The heme-binding protein hemopexin is a multi-functional protectant against hemoglobin (Hb)-derived heme toxicity as well as mitigating heme-mediated effects on immune cells, endothelial cells, and stem cells that collectively contribute to driving inflammation, perturbing vascular hemostasis and blood–brain barrier function. Heme toxicity, which may lead to iron toxicity, is recognized increasingly in a wide range of conditions involving hemolysis and immune system activation and, in this review, we highlight some newly identified actions of heme and hemopexin especially in situations where normal processes fail to maintain heme and iron homeostasis. Finally, we present preliminary data showing that the cytokine IL-6 cross talks with activation of the c-Jun N-terminal kinase pathway in response to heme-hemopexin in models of hepatocytes. This indicates another level of complexity in the cell responses to elevated heme via the HPX system when the immune system is activated and/or in the presence of inflammation.

Evolution of the SOUL Heme-Binding Protein Superfamily Across Eukarya

2016 ◽  
Vol 82 (6) ◽  
pp. 279-290 ◽  
Author(s):  
Antonio Emidio Fortunato ◽  
Paolo Sordino ◽  
Nikos Andreakis
Keyword(s):  
Binding Protein ◽  
Heme Binding ◽  
Protein Superfamily ◽  
Heme Binding Protein
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