scholarly journals Protein-tyrosine Phosphatase H1 Controls Growth Hormone Receptor Signaling and Systemic Growth

2007 ◽  
Vol 282 (48) ◽  
pp. 35405-35415 ◽  
Author(s):  
Iwona Pilecka ◽  
Claudia Patrignani ◽  
Rosanna Pescini ◽  
Marie-Laure Curchod ◽  
Dominique Perrin ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Protein Tyrosine Phosphatase ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Tyrosine Phosphatase ◽  
Receptor Signaling ◽  
Protein Tyrosine

Laron syndrome – A case Report

JMS SKIMS ◽  
2017 ◽  
Vol 20 (2) ◽  
pp. 104-106
Author(s):  
Javaid Ahmad Bhat ◽  
Moomin Hussain Bhat ◽  
Hilal Bhat ◽  
Mona Sood ◽  
Shariq Rashid Masoodi
Keyword(s):  
Growth Hormone ◽  
Case Report ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Genetic Disorder ◽  
Female Child ◽  
Receptor Signaling ◽  
Laron Syndrome ◽  
Rare Genetic Disorder ◽  
Igf I

Background : Laron & colleagues (1966) reported a rare genetic disorder in Israliei Jewish sublings which was characterized by insensitivity to growth hormone due to abnormality in growth hormone receptor or post receptor signaling pathway.Case Report: We hereby report a case of a 5 year old female child who presented to us with features similar to Laron syndrome. The diagnosis was made & confirmed by various Lab. investigations like low IGF-I levels and managed accordingly. JMS 2017; 20 (2):104-106  

scholarly journals Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice

2010 ◽  
Vol 120 (11) ◽  
pp. 4007-4020 ◽  
Author(s):  
Mahendra D. Mavalli ◽  
Douglas J. DiGirolamo ◽  
Yong Fan ◽  
Ryan C. Riddle ◽  
Kenneth S. Campbell ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Growth Hormone ◽  
Insulin Sensitivity ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Muscle Development ◽  
Receptor Signaling ◽  
Skeletal Muscle Development

scholarly journals Disruption of Lymphocyte Function and Signaling in CD45–associated Protein–null Mice

1998 ◽  
Vol 187 (11) ◽  
pp. 1863-1870 ◽  
Author(s):  
Akio Matsuda ◽  
Satoshi Motoya ◽  
Shioko Kimura ◽  
Renee McInnis ◽  
Abby L. Maizel ◽  
...  
Keyword(s):  
Signal Transduction ◽  
T Cells ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Kinases ◽  
Tyrosine Phosphatase ◽  
Antigen Receptor ◽  
Lymphocyte Function ◽  
Receptor Signaling ◽  
Protein Tyrosine ◽  
Antigen Receptor Signaling

CD45-AP specifically associates with CD45, a protein tyrosine phosphatase essential for lymphocyte differentiation and antigen receptor–mediated signal transduction. CD45 is thought to mediate antigen receptor signaling by dephosphorylating regulatory tyrosine residues on Src family protein tyrosine kinases such as Lck. However, the mechanism for regulating CD45 protein tyrosine phosphatase activity remains unclear. CD45-AP–null mice were created to examine the role of CD45-AP in CD45-mediated signal transduction. T and B lymphocytes showed reduced proliferation in response to antigen receptor stimulation. Both mixed leukocyte reaction and cytotoxic T lymphocyte functions of T cells were also markedly decreased in CD45-AP–null mice. Interestingly, the interaction between CD45 and Lck was significantly reduced in CD45-AP–null T cells, indicating that CD45-AP directly or indirectly mediates the interaction of CD45 with Lck. Our data indicate that CD45-AP is required for normal antigen receptor signaling and function in lymphocytes.

scholarly journals Growth hormone receptor signaling is dispensable for HSC function and aging

Blood ◽  
2014 ◽  
Vol 124 (20) ◽  
pp. 3076-3080 ◽  
Author(s):  
Morag H. Stewart ◽  
Paula Gutierrez-Martinez ◽  
Isabel Beerman ◽  
Brian Garrison ◽  
Emily J. Gallagher ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Receptor Signaling ◽  
Hematopoietic System ◽  
Key Points

Key Points Ghr is specifically expressed on HSCs within the hematopoietic system and is dynamically regulated upon HSC aging and activation. Ghr is dispensable for HSC function.

scholarly journals Skeletal Muscle Growth Hormone Receptor Signaling Regulates Basal, but Not Fasting-Induced, Lipid Oxidation

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e44777 ◽  
Author(s):  
Archana Vijayakumar ◽  
YingJie Wu ◽  
Nicholas J. Buffin ◽  
Xiaosong Li ◽  
Hui Sun ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Growth Hormone ◽  
Lipid Oxidation ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Muscle Growth ◽  
Receptor Signaling ◽  
Skeletal Muscle Growth
Sign in / Sign up

Export Citation Format

Share Document