scholarly journals Immediate-Early and Delayed Primary Response Genes Are Distinct in Function and Genomic Architecture

2007 ◽  
Vol 282 (33) ◽  
pp. 23981-23995 ◽  
Author(s):  
John W. Tullai ◽  
Michael E. Schaffer ◽  
Steven Mullenbrock ◽  
Gabriel Sholder ◽  
Simon Kasif ◽  
...  
Keyword(s):  
Primary Response ◽  
Immediate Early ◽  
Primary Response Genes ◽  
Genomic Architecture

scholarly journals Nerve growth factor employs multiple pathways to induce primary response genes in PC12 cells.

1992 ◽  
Vol 3 (3) ◽  
pp. 363-371 ◽  
Author(s):  
A Batistatou ◽  
C Volonté ◽  
L A Greene
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Pc12 Cells ◽  
Primary Response ◽  
Purine Analogues ◽  
Signaling Mechanism ◽  
Nerve Growth ◽  
Primary Response Genes ◽  
Run Off ◽  
Ngf Signaling

Nerve growth factor (NGF) leads to neuronal differentiation of PC12 cells and promotes their survival in serum-free medium. Past studies have shown that purine analogues block some of the effects of NGF but not others and thus that they can be used to dissect the mechanistic pathways of its action. In the present work we used 2-aminopurine (2-AP) and 6-thioguanine (6-TG) to examine whether NGF causes activation of primary response genes through a single signaling pathway or via multiple pathways. Northern blot analysis and nuclear run-off transcription assays were used to assess the activation of c-fos, c-jun, TIS1, TIS8, and TIS11 after exposure of PC12 cells to NGF in the presence or absence of 2-AP and 6-TG. Our findings indicate that NGF appears to employ at least three distinct pathways to induce early genes in PC12 cells. This suggests that the NGF signaling mechanism diverges at an early point after interaction of NGF with its receptor.

scholarly journals Myeloid differentiation (MyD) primary response genes in hematopoiesis

Oncogene ◽  
2002 ◽  
Vol 21 (21) ◽  
pp. 3391-3402 ◽  
Author(s):  
Dan A Liebermann ◽  
Barbara Hoffman
Keyword(s):  
Primary Response ◽  
Myeloid Differentiation ◽  
Primary Response Genes

Synthesis, degradation, and subcellular localization of proteins encoded by the primary response genes TIS7/PC4 and TIS21/PC3

1994 ◽  
Vol 158 (1) ◽  
pp. 205-213 ◽  
Author(s):  
Brian C. Varnum ◽  
Srinivasa T. Reddy ◽  
Raymond A. Koski ◽  
Harvey R. Herschman
Keyword(s):  
Subcellular Localization ◽  
Primary Response ◽  
Primary Response Genes

scholarly journals Different duration of parathyroid hormone exposure distinctively regulates primary response genes Nurr1 and RANKL in osteoblasts

PLoS ONE ◽  
2018 ◽  
Vol 13 (12) ◽  
pp. e0208514 ◽  
Author(s):  
Hyewon Choi ◽  
Clara E. Magyar ◽  
Jeanne M. Nervina ◽  
Sotirios Tetradis
Keyword(s):  
Parathyroid Hormone ◽  
Primary Response ◽  
Primary Response Genes ◽  
Hormone Exposure
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