scholarly journals Distinct Uptake Mechanisms but Similar Intracellular Processing of Two Different Toll-like Receptor Ligand-Peptide Conjugates in Dendritic Cells

2007 ◽  
Vol 282 (29) ◽  
pp. 21145-21159 ◽  
Author(s):  
Selina Khan ◽  
Martijn S. Bijker ◽  
Jimmy J. Weterings ◽  
Hans J. Tanke ◽  
Gosse J. Adema ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Toll Like Receptor ◽  
Peptide Conjugates ◽  
Receptor Ligand ◽  
Intracellular Processing ◽  
Uptake Mechanisms

scholarly journals CD73+ Dendritic Cells in Cascading Th17 Responses of Experimental Autoimmune Uveitis-Induced Mice

2020 ◽  
Vol 11 ◽  
Author(s):  
MinHee K. Ko ◽  
Hui Shao ◽  
Henry J. Kaplan ◽  
Deming Sun
Keyword(s):  
Dendritic Cells ◽  
Critical Role ◽  
Γδ T Cells ◽  
Adenosine Monophosphate ◽  
Toll Like Receptor ◽  
Promoting Effect ◽  
Receptor Ligand ◽  
Antigen Presenting ◽  
Different Levels ◽  
Experimental Autoimmune

Previous studies have shown that CD73 is pivotal in the conversion of pro-inflammatory adenosine triphosphate into anti-inflammatory adenosine and that immune cells of the same type that express different levels of CD73 are functionally distinct. In this study we show that adenosine enhances the Th17 promoting effect of dendritic cells (DCs), and DCs expressing CD73 critically augment Th17 responses. Bone marrow dendritic cells (BMDCs) do not constantly express CD73; however, a significant portion of the BMDCs expressed CD73 after exposure to Toll-like receptor ligand, leading to stronger Th17 responses by converting adenosine monophosphate to adenosine. We show that the CD73+ BMDCs play a critical role in cascading Th17 responses, and CD73+ BMDCs are functionally augmented after treatment with Toll-like receptor ligand. Splenic antigen presenting cells (DCs) of CD73−/− mouse have a poor Th17-stimulating effect, even after exposure to lipopolysaccharide (LPS) or γδ T cells, indicating that induction of CD73+ DCs is critically involved in augmented Th17 responses. We conclude that CD73+ DCs critically trigger cascading Th17 responses, and the activated Th17 cells that express CD73 further augment Th17 responses, leading to cascading exacerbation. Hence, disabling the CD73 function of DCs should block this cascading response and mitigate Th17 responses.

scholarly journals Efficient Induction of Antitumor Immunity by Synthetic Toll-like Receptor Ligand–Peptide Conjugates

2014 ◽  
Vol 2 (8) ◽  
pp. 756-764 ◽  
Author(s):  
Gijs G. Zom ◽  
Selina Khan ◽  
Cedrik M. Britten ◽  
Vinod Sommandas ◽  
Marcel G.M. Camps ◽  
...  
Keyword(s):  
Antitumor Immunity ◽  
Toll Like Receptor ◽  
Peptide Conjugates ◽  
Receptor Ligand ◽  
Efficient Induction

scholarly journals Immunomodulatory Response of Toll-like Receptor Ligand–Peptide Conjugates in Food Allergy

2021 ◽  
Author(s):  
Jorge Losada Méndez ◽  
Francisca Palomares ◽  
Francisca Gómez ◽  
Pedro Ramírez-López ◽  
Javier Ramos-Soriano ◽  
...  
Keyword(s):  
Food Allergy ◽  
Toll Like Receptor ◽  
Peptide Conjugates ◽  
Receptor Ligand

Toll-like receptor ligand-induced synergistic interferon gene expression in human monocyte-derived dendritic cells

Cytokine ◽  
2009 ◽  
Vol 48 (1-2) ◽  
pp. 131-132
Author(s):  
Sanna M. Mäkelä ◽  
Pamela Österlund ◽  
Taija E. Pietilä ◽  
Ilkka Julkunen
Keyword(s):  
Gene Expression ◽  
Dendritic Cells ◽  
Human Monocyte ◽  
Toll Like Receptor ◽  
Receptor Ligand ◽  
Interferon Gene

scholarly journals Toll-like receptor ligand activation of murine bone marrow-derived dendritic cells

Immunology ◽  
2009 ◽  
Vol 126 (4) ◽  
pp. 475-484 ◽  
Author(s):  
Rebecca J. Dearman ◽  
Marie Cumberbatch ◽  
Gavin Maxwell ◽  
David A. Basketter ◽  
Ian Kimber
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
Toll Like Receptor ◽  
Receptor Ligand ◽  
Ligand Activation ◽  
Murine Bone Marrow
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